P52209 | 6PGD_HUMAN | 6-phosphogluconate dehydrogenase, decarboxylating (PGD)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00393 | 6PGD - 6-phosphogluconate dehydrogenase, C-terminal domain | 180~469 | |
| PF03446 | NAD_binding_2 - NAD binding domain of 6-phosphogluconate dehydrogenase | 5~164 |
3D structures mapped by conservation among orthologs
[ Domain: "6-phosphogluconate dehydrogenase C-terminal domain-like" // 6PGD ]
[ Domain: "NAD(P)-binding Rossmann-fold domains" // NAD_binding_2 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL36327 |  |
IC50 | = | 210.0 | nM | 442.38 | O=C(O[C@@H]1Cc2c(O)cc(O)cc2O[C@@H]1c1ccc(O)c(O)c1)c1cc(O)c(O)c(O)c1 | Homo sapiens | CHEMBL921930 | single protein format |
| CHEMBL297453 |  |
IC50 | = | 720.0 | nM | 458.38 | O=C(O[C@@H]1Cc2c(O)cc(O)cc2O[C@@H]1c1cc(O)c(O)c(O)c1)c1cc(O)c(O)c(O)c1 | Homo sapiens | CHEMBL921930 | single protein format |
| CHEMBL116018 |  |
Ki | = | 10.0 | nM | 231.1 | O=C(NO)[C@H](O)[C@H](O)COP(=O)(O)O | Homo sapiens | CHEMBL618442 | assay format |
| CHEMBL324609 |  |
Ki | = | 35.0 | nM | 271.16 | CC1(C)O[C@H](COP(=O)(O)O)[C@H](C(=O)NO)O1 | Homo sapiens | CHEMBL618442 | assay format |
| CHEMBL114269 |  |
Ki | = | 80.0 | nM | 315.17 | CC(=O)O[C@H](COP(=O)(O)O)[C@@H](OC(C)=O)C(=O)NO | Homo sapiens | CHEMBL618442 | assay format |
| CHEMBL1160945 |  |
Ki | = | 130.0 | nM | 216.08 | O=C(O)[C@H](O)[C@H](O)COP(=O)(O)O | Homo sapiens | CHEMBL618442 | assay format |