P51955 | NEK2_HUMAN | Serine/threonine-protein kinase Nek2 (NEK2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 8~270 |
3D structures mapped by conservation among orthologs
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4062453 |  |
IC50 | = | 1.0 | nM | 498.56 | CN(C)CCn1cc(-c2ccn3c(-c4ccc(C(N)=O)c(OCc5cccc(F)c5)c4)cnc3c2)cn1 | Homo sapiens | CHEMBL4003695 | cell-based format |
| CHEMBL4063211 |  |
IC50 | = | 3.0 | nM | 480.57 | CN(C)CCn1cc(-c2ccn3c(-c4ccc(C(N)=O)c(OCc5ccccc5)c4)cnc3c2)cn1 | Homo sapiens | CHEMBL4003695 | cell-based format |
| CHEMBL4860697 |  |
IC50 | = | 3.2 | nM | 568.63 | C[C@@H](Oc1cc(-c2cnc3cc(-c4cnn(CCN(C)C)c4)ccn23)sc1C(N)=O)c1ccccc1C(F)(F)F | Homo sapiens | CHEMBL4831022 | single protein format |
| CHEMBL1802381 |  |
IC50 | < | 6.0 | nM | 286.72 | O=C1Nc2ccc(C(=O)CCl)cc2/C1=C/c1ccc[nH]1 | Homo sapiens | CHEMBL1804637 | single protein format |
| CHEMBL4091089 |  |
IC50 | = | 7.0 | nM | 548.57 | CN(C)CCn1cc(-c2ccn3c(-c4ccc(C(N)=O)c(OCc5cccc(C(F)(F)F)c5)c4)cnc3c2)cn1 | Homo sapiens | CHEMBL4003695 | cell-based format |
| CHEMBL4761747 |  |
IC50 | = | 10.0 | nM | 356.41 | C#Cc1nc(Nc2cccc(CS(=O)(=O)N(C)C)c2)nc2[nH]cnc12 | Homo sapiens | CHEMBL4700126 | assay format |
| CHEMBL4763380 |  |
IC50 | = | 10.0 | nM | 318.34 | C#Cc1nc(Nc2ccc3c(c2)C(=O)N(C)CC3)nc2[nH]cnc12 | Homo sapiens | CHEMBL4700126 | assay format |
| CHEMBL1980297 |  |
IC50 | = | 13.0 | nM | 488.55 | Nc1ncc(-c2cnn(CCO)c2)c2scc(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12 | Homo sapiens | CHEMBL5252708 | single protein format |
| CHEMBL1802383 |  |
IC50 | = | 20.0 | nM | 301.73 | Cc1nc[nH]c1/C=C1\C(=O)Nc2ccc(C(=O)CCl)cc21 | Homo sapiens | CHEMBL1804637 | single protein format |
| CHEMBL1794070 |  |
IC50 | = | 21.0 | nM | 511.05 | C[C@@H](Oc1cc(-n2cnc3ccc(OC4CCN(C)CC4)cc32)sc1C(N)=O)c1ccccc1Cl | Homo sapiens | CHEMBL960866 | single protein format |
| CHEMBL2042135 |  |
IC50 | = | 22.0 | nM | 490.55 | C[C@H](/C=C\C(F)(F)F)Oc1cc(-c2cc(-c3cc(CN(C)C)cs3)cnc2N)ccc1C(N)=O | Homo sapiens | CHEMBL2044151 | single protein format |
| CHEMBL1615278 |  |
IC50 | = | 25.0 | nM | 544.6 | C[C@@H](Oc1cc(-n2cnc3ccc(OC4CCN(C)CC4)cc32)sc1C(N)=O)c1ccccc1C(F)(F)F | Homo sapiens | CHEMBL960866 | single protein format |
| CHEMBL4796125 |  |
IC50 | = | 26.0 | nM | 292.3 | C#Cc1nc(Nc2cccc(C(=O)NC)c2)nc2[nH]cnc12 | Homo sapiens | CHEMBL4700126 | assay format |
| CHEMBL2042136 |  |
IC50 | = | 37.0 | nM | 540.61 | C[C@@H](Oc1cc(-c2cc(-c3cc(CN(C)C)cs3)cnc2N)ccc1C(N)=O)c1ccccc1C(F)(F)F | Homo sapiens | CHEMBL2044151 | single protein format |
| CHEMBL4743876 |  |
IC50 | = | 39.0 | nM | 292.3 | C#Cc1nc(Nc2cccc(NC(C)=O)c2)nc2[nH]cnc12 | Homo sapiens | CHEMBL4700126 | assay format |
| CHEMBL1997822 |  |
IC50 | = | 40.0 | nM | 433.56 | Cc1cc2cc(-c3csc4c(-c5cccc(S(C)(=O)=O)c5)cnc(N)c34)ccc2[nH]1 | Homo sapiens | CHEMBL5252708 | single protein format |
| CHEMBL4779487 |  |
IC50 | = | 42.0 | nM | 318.34 | C#Cc1nc(Nc2ccc3c(c2)CN(C)C(=O)C3)nc2[nH]cnc12 | Homo sapiens | CHEMBL4700126 | assay format |
| CHEMBL2042036 |  |
IC50 | = | 47.0 | nM | 554.64 | Cc1cc(-c2cnc(N)c(-c3ccc(C(N)=O)c(OC(C)c4ccccc4C(F)(F)F)c3)c2)sc1CN(C)C | Homo sapiens | CHEMBL2044151 | single protein format |
| CHEMBL2042035 |  |
IC50 | = | 47.0 | nM | 540.61 | CC(Oc1cc(-c2cc(-c3ccc(CN(C)C)s3)cnc2N)ccc1C(N)=O)c1ccccc1C(F)(F)F | Homo sapiens | CHEMBL2044151 | single protein format |
| CHEMBL4775990 |  |
IC50 | = | 50.0 | nM | 306.33 | C#Cc1nc(Nc2cccc(C(=O)N(C)C)c2)nc2[nH]cnc12 | Homo sapiens | CHEMBL4700126 | assay format |