P51685 | CCR8_HUMAN | C-C chemokine receptor type 8 (CCR8)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00001 | 7tm_1 - 7 transmembrane receptor (rhodopsin family) | 52~300 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5424187 |  |
IC50 | = | 1.0 | nM | 464.03 | Cc1ccccc1C(=O)Nc1c(C)cc(S(=O)(=O)N[C@H](C)C2CCN(C)CC2)cc1Cl | Homo sapiens | CHEMBL5384113 | cell-based format |
| CHEMBL5404620 |  |
IC50 | = | 1.2 | nM | 465.62 | Cc1ccccc1C(=O)Nc1ccc(S(=O)(=O)N[C@H](C)C2CCN(C)CC2)c2ccccc12 | Homo sapiens | CHEMBL5384113 | cell-based format |
| CHEMBL5397693 |  |
IC50 | = | 1.3 | nM | 464.03 | Cc1cc(S(=O)(=O)N[C@H](C)C2CCN(C)CC2)ccc1NC(=O)c1cccc(Cl)c1C | Homo sapiens | CHEMBL5384113 | cell-based format |
| CHEMBL5412884 |  |
IC50 | = | 1.7 | nM | 464.03 | Cc1cc(S(=O)(=O)N[C@H](C)C2CCN(C)CC2)ccc1NC(=O)c1cc(Cl)ccc1C | Homo sapiens | CHEMBL5384113 | cell-based format |
| CHEMBL5411391 |  |
IC50 | = | 1.7 | nM | 464.03 | Cc1cc(S(=O)(=O)N[C@H](C)C2CCN(C)CC2)ccc1NC(=O)c1ccc(Cl)cc1C | Homo sapiens | CHEMBL5384113 | cell-based format |
| CHEMBL5399936 |  |
IC50 | = | 4.0 | nM | 443.61 | Cc1cc(S(=O)(=O)N[C@H](C)C2CCN(C)CC2)c(C)cc1NC(=O)c1ccccc1C | Homo sapiens | CHEMBL5384113 | cell-based format |
| CHEMBL221251 |  |
IC50 | = | 4.0 | nM | 549.7 | Cc1ccccc1C(=O)Nc1ccc(S(=O)(=O)NC2CCN(C(=O)N3CCN(C)CC3)CC2)c2ccccc12 | Homo sapiens | CHEMBL5384113 | cell-based format |
| CHEMBL5404280 |  |
IC50 | = | 6.0 | nM | 447.58 | Cc1cc(S(=O)(=O)N[C@H](C)C2CCN(C)CC2)c(F)cc1NC(=O)c1ccccc1C | Homo sapiens | CHEMBL5384113 | cell-based format |
| CHEMBL5412094 |  |
IC50 | = | 6.0 | nM | 464.03 | Cc1cc(S(=O)(=O)N[C@H](C)C2CCN(C)CC2)c(Cl)cc1NC(=O)c1ccccc1C | Homo sapiens | CHEMBL5384113 | cell-based format |
| CHEMBL5400674 |  |
IC50 | = | 13.0 | nM | 443.61 | CCc1cc(S(=O)(=O)N[C@H](C)C2CCN(C)CC2)ccc1NC(=O)c1ccccc1C | Homo sapiens | CHEMBL5384113 | cell-based format |
| CHEMBL5400852 |  |
IC50 | = | 13.8 | nM | 451.59 | Cc1ccccc1C(=O)Nc1ccc(S(=O)(=O)N[C@H](C)C2CCNCC2)c2ccccc12 | Homo sapiens | CHEMBL5384113 | cell-based format |
| CHEMBL5407071 |  |
IC50 | = | 24.0 | nM | 429.59 | Cc1cc(S(=O)(=O)N[C@H](C)C2CCN(C)CC2)ccc1NC(=O)c1ccccc1C | Homo sapiens | CHEMBL5384113 | cell-based format |
| CHEMBL5434812 |  |
IC50 | = | 26.0 | nM | 457.64 | CCCN1CCC([C@@H](C)NS(=O)(=O)c2ccc(NC(=O)c3ccccc3C)c(C)c2)CC1 | Homo sapiens | CHEMBL5384113 | cell-based format |
| CHEMBL5400080 |  |
IC50 | = | 27.0 | nM | 450.0 | Cc1ccccc1C(=O)Nc1ccc(S(=O)(=O)N[C@H](C)C2CCN(C)CC2)cc1Cl | Homo sapiens | CHEMBL5384113 | cell-based format |
| CHEMBL5412408 |  |
IC50 | = | 28.0 | nM | 435.63 | Cc1cc(S(=O)(=O)N[C@H](C)C2CCN(C)CC2)ccc1NC(=O)C1CCCCCC1 | Homo sapiens | CHEMBL5384113 | cell-based format |
| CHEMBL5399315 |  |
IC50 | = | 29.0 | nM | 451.59 | Cc1ccccc1C(=O)Nc1ccc(S(=O)(=O)NC(C)C2CCNCC2)c2ccccc12 | Homo sapiens | CHEMBL5384113 | cell-based format |
| CHEMBL5437244 |  |
IC50 | = | 33.0 | nM | 440.57 | Cc1ccccc1C(=O)Nc1ccc(S(=O)(=O)N[C@H](C)C2CCN(C)CC2)cc1C#N | Homo sapiens | CHEMBL5384113 | cell-based format |
| CHEMBL5410064 |  |
IC50 | = | 33.0 | nM | 435.62 | Cc1cc(S(=O)(=O)N[C@H](C)C2CCN(C)CC2)ccc1NC(=O)c1ccsc1C | Homo sapiens | CHEMBL5384113 | cell-based format |
| CHEMBL5402712 |  |
IC50 | = | 37.0 | nM | 464.03 | Cc1cc(S(=O)(=O)N[C@H](C)C2CCN(C)CC2)ccc1NC(=O)c1c(C)cccc1Cl | Homo sapiens | CHEMBL5384113 | cell-based format |
| CHEMBL5397155 |  |
IC50 | = | 46.0 | nM | 483.56 | Cc1cc(S(=O)(=O)N[C@H](C)C2CCN(C)CC2)ccc1NC(=O)c1ccccc1C(F)(F)F | Homo sapiens | CHEMBL5384113 | cell-based format |