P51679 | CCR4_HUMAN | C-C chemokine receptor type 4 (CCR4)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00001 | 7tm_1 - 7 transmembrane receptor (rhodopsin family) | 56~304 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL377421 |  |
IC50 | = | 14.0 | nM | 509.64 | FC(F)(F)c1ccccc1CN(Cc1csc(Nc2cccc3ccccc23)n1)CC1CCCCC1 | Homo sapiens | CHEMBL870148 | cell-based format |
| CHEMBL207642 |  |
IC50 | = | 18.0 | nM | 447.69 | c1ccc2c(Nc3nc(CN(CC4CCCCC4)CC4CCCCC4)cs3)cccc2c1 | Homo sapiens | CHEMBL870148 | cell-based format |
| CHEMBL233046 |  |
IC50 | = | 20.0 | nM | 500.43 | O=C([C@@H]1CCCCN1)N1CCN(c2nc(NCc3ccc(Cl)cc3Cl)c3cccnc3n2)CC1 | Homo sapiens | CHEMBL890042 | cell-based format |
| CHEMBL598070 |  |
IC50 | = | 21.2 | nM | 290.32 | Cc1c(N2CCN(C)CC2)c(=O)oc2cc(O)cc(O)c12 | Homo sapiens | CHEMBL1072093 | cell-based format |
| CHEMBL4642563 |  |
IC50 | = | 36.0 | nM | 518.45 | C[C@H](c1ccc(Cl)cc1Cl)n1nc(C(N)=O)c2ncc(N3CC([C@H]4CCCN(CCO)C4)C3)nc21 | Homo sapiens | CHEMBL4630441 | cell-based format |
| CHEMBL205279 |  |
IC50 | = | 37.0 | nM | 285.42 | Cn1ccc2c(Nc3nc(C(C)(C)C)cs3)cccc21 | Homo sapiens | CHEMBL870148 | cell-based format |
| CHEMBL4641127 |  |
IC50 | = | 40.0 | nM | 530.5 | CC(=O)NCCN1CCC[C@H](C2CN(c3cnc4c(C)nn([C@H](C)c5ccc(Cl)cc5Cl)c4n3)C2)C1 | Homo sapiens | CHEMBL4630441 | cell-based format |
| CHEMBL4475665 |  |
IC50 | = | 44.0 | nM | 495.46 | C[C@@H]1CC(c2cnc3c(C#N)nn([C@H](C)c4ccc(Cl)cc4Cl)c3n2)=CC[C@@H]1N1CCC[C@H]1C | Homo sapiens | CHEMBL4367190 | cell-based format |
| CHEMBL207320 |  |
IC50 | = | 45.0 | nM | 367.56 | CC(C)CN(Cc1csc(Nc2cccc3ccccc23)n1)CC(C)C | Homo sapiens | CHEMBL870148 | cell-based format |
| CHEMBL4637143 |  |
IC50 | = | 50.0 | nM | 500.43 | C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(CCO)C4)C3)nc21 | Homo sapiens | CHEMBL4630441 | cell-based format |
| CHEMBL372399 |  |
IC50 | = | 50.0 | nM | 449.39 | O=C([C@H]1CCCCN1)N1CCN(c2nccc(NCc3ccc(Cl)cc3Cl)n2)CC1 | Homo sapiens | CHEMBL863428 | cell-based format |
| CHEMBL4558456 |  |
IC50 | = | 58.0 | nM | 514.46 | C[C@@H]1CN(c2cnc3c(C#N)nn([C@H](C)c4ccc(Cl)cc4Cl)c3n2)CC[C@@H]1N1CCC[C@H]1CO | Homo sapiens | CHEMBL4367190 | cell-based format |
| CHEMBL4645325 |  |
IC50 | = | 59.0 | nM | 558.56 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCNC(=O)C(C)C)C4)C3)cnc12 | Homo sapiens | CHEMBL4630441 | cell-based format |
| CHEMBL200465 |  |
IC50 | = | 60.0 | nM | 435.36 | O=C([C@H]1CCCN1)N1CCN(c2nccc(NCc3ccc(Cl)cc3Cl)n2)CC1 | Homo sapiens | CHEMBL863428 | cell-based format |
| CHEMBL487635 |  |
IC50 | = | 70.0 | nM | 453.63 | COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(NC3CCCCCC3)c2cc1OC | Homo sapiens | CHEMBL968019 | single protein format |
| CHEMBL4459231 |  |
IC50 | = | 70.0 | nM | 511.46 | C[C@@H]1CC(c2cnc3c(C#N)nn([C@H](C)c4ccc(Cl)cc4Cl)c3n2)=CC[C@@H]1N1CCC[C@H]1CO | Homo sapiens | CHEMBL4367190 | cell-based format |
| CHEMBL508207 |  |
IC50 | = | 73.0 | nM | 467.66 | COc1cc2nc(N3CCC(N4CCCCC4)CC3)nc(NC3CCCCCC3)c2cc1OC | Homo sapiens | CHEMBL946416 | cell-based format |
| CHEMBL4634054 |  |
IC50 | = | 74.0 | nM | 489.45 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCO)C4)C3)cnc12 | Homo sapiens | CHEMBL4630441 | cell-based format |
| CHEMBL379460 |  |
IC50 | = | 80.0 | nM | 282.41 | CC(C)(C)c1csc(Nc2cccc3ccccc23)n1 | Homo sapiens | CHEMBL870148 | cell-based format |
| CHEMBL394859 |  |
IC50 | = | 80.0 | nM | 486.41 | O=C([C@@H]1CCCN1)N1CCN(c2nc(NCc3ccc(Cl)cc3Cl)c3cccnc3n2)CC1 | Homo sapiens | CHEMBL890042 | cell-based format |