P51677 | CCR3_HUMAN | C-C chemokine receptor type 3 (CCR3)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00001 | 7tm_1 - 7 transmembrane receptor (rhodopsin family) | 51~301 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL518571 |  |
IC50 | = | 0.12 | nM | 550.64 | CN1CC(C)(NC(=O)Nc2cccc(-c3nnnn3C)c2)C(CN2CCC[C@@H](Cc3ccc(F)cc3)C2)OC1=O | Homo sapiens | CHEMBL1019589 | single protein format |
| CHEMBL505914 |  |
IC50 | = | 0.15 | nM | 587.1 | CN1CC(C)(NC(=O)Nc2cccc(-c3nnnn3C)c2)C(CN2CCC[C@@H](Cc3ccc(F)cc3)C2)OC1=O.Cl | Homo sapiens | CHEMBL1019589 | single protein format |
| CHEMBL398548 |  |
IC50 | = | 0.2 | nM | 483.59 | CCCN(CCCc1ccc(F)cc1)C[C@H](O)[C@@H](C)NC(=O)Nc1cccc(-c2nnnn2C)c1 | Homo sapiens | CHEMBL945751 | cell-based format |
| CHEMBL254095 |  |
IC50 | = | 0.2 | nM | 511.65 | CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(CC)[C@@H](C)CCc2ccc(F)cc2)cc(-c2nnnn2C)c1 | Homo sapiens | CHEMBL945751 | cell-based format |
| CHEMBL251837 |  |
IC50 | = | 0.2 | nM | 469.57 | CCN(CCCc1ccc(F)cc1)C[C@H](O)[C@@H](C)NC(=O)Nc1cccc(-c2nnnn2C)c1 | Homo sapiens | CHEMBL945751 | cell-based format |
| CHEMBL464902 |  |
IC50 | = | 0.23 | nM | 536.61 | CN1C[C@@H](NC(=O)Nc2cccc(-c3nnnn3C)c2)[C@H](CN2CCC[C@@H](Cc3ccc(F)cc3)C2)OC1=O | Homo sapiens | CHEMBL1019589 | single protein format |
| CHEMBL437396 |  |
IC50 | = | 0.3 | nM | 483.59 | CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(C)CCCc2ccc(F)cc2)cc(-c2nnnn2C)c1 | Homo sapiens | CHEMBL945751 | cell-based format |
| CHEMBL252035 |  |
IC50 | = | 0.3 | nM | 469.57 | CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CNCCCc2ccc(F)cc2)cc(-c2nnnn2C)c1 | Homo sapiens | CHEMBL945751 | cell-based format |
| CHEMBL399495 |  |
IC50 | = | 0.3 | nM | 481.58 | C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | Homo sapiens | CHEMBL945751 | cell-based format |
| CHEMBL2113077 |  |
IC50 | = | 0.3 | nM | 463.6 | O=C(Nc1ccc2[nH]ncc2c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | Homo sapiens | CHEMBL831708 | cell-based format |
| CHEMBL429323 |  |
IC50 | = | 0.3 | nM | 479.6 | C[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nccn2C)c1 | Homo sapiens | CHEMBL947057 | cell-based format |
| CHEMBL465272 |  |
IC50 | = | 0.37 | nM | 489.62 | Cc1csc(NC(=O)NC2(C)CN(C)C(=O)OC2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)n1 | Homo sapiens | CHEMBL1019589 | single protein format |
| CHEMBL428062 |  |
IC50 | = | 0.4 | nM | 497.62 | CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(CC)CCCc2ccc(F)cc2)cc(-c2nnnn2C)c1 | Homo sapiens | CHEMBL945751 | cell-based format |
| CHEMBL254503 |  |
IC50 | = | 0.4 | nM | 453.55 | C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN(C)[C@@H](C)[C@@H](O)c1ccccc1 | Homo sapiens | CHEMBL945751 | cell-based format |
| CHEMBL2113074 |  |
IC50 | = | 0.4 | nM | 462.61 | O=C(Nc1ccc2[nH]ccc2c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | Homo sapiens | CHEMBL831708 | cell-based format |
| CHEMBL403838 |  |
IC50 | = | 0.4 | nM | 509.63 | CC(C)[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nnnn2C)c1 | Homo sapiens | CHEMBL947057 | cell-based format |
| CHEMBL251838 |  |
IC50 | = | 0.4 | nM | 495.6 | C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN(CCCc1ccc(F)cc1)CC1CC1 | Homo sapiens | CHEMBL945751 | cell-based format |
| CHEMBL400378 |  |
IC50 | = | 0.4 | nM | 481.58 | C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN(CCCc1ccc(F)cc1)C1CC1 | Homo sapiens | CHEMBL945751 | cell-based format |
| CHEMBL252631 |  |
IC50 | = | 0.4 | nM | 455.54 | C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN(C)CCCc1ccc(F)cc1 | Homo sapiens | CHEMBL945751 | cell-based format |
| CHEMBL461445 |  |
IC50 | = | 0.47 | nM | 538.63 | CCN(CCCc1ccc(F)cc1)CC1OC(=O)N(C)CC1(C)NC(=O)Nc1cccc(-c2nnnn2C)c1 | Homo sapiens | CHEMBL1019589 | single protein format |