P51617 | IRAK1_HUMAN | Interleukin-1 receptor-associated kinase 1 (IRAK1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 214~514 | |
| PF00531 | Death - Death domain | 28~102 |
3D structures mapped by conservation among orthologs
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5283628 |  |
IC50 | = | 2.0 | nM | 457.54 | CN1CCC(n2cc(Nc3nc(OC4(C)CC4)c4nc(-c5cncnc5)ccc4n3)cn2)CC1 | Homo sapiens | CHEMBL5246678 | single protein format |
| CHEMBL4568087 |  |
IC50 | = | 9.0 | nM | 421.53 | Cn1cc(-c2cnc3c(-c4csc(C(=O)N[C@@H]5CCCC[C@@H]5N)c4)cnn3c2)cn1 | Homo sapiens | CHEMBL4479731 | assay format |
| CHEMBL4782804 |  |
IC50 | = | 9.0 | nM | 452.47 | C=CC(=O)Nc1cccc(C(=O)Nc2ccc(NC(=O)c3cccc(-c4ccn[nH]4)n3)cc2)c1 | Homo sapiens | CHEMBL4731589 | single protein format |
| CHEMBL256713 |  |
IC50 | = | 9.0 | nM | 379.42 | COc1cc(N2CCOCC2)ccc1NC(=O)c1cccc(-c2ccn[nH]2)n1 | Homo sapiens | CHEMBL4731591 | assay format |
| CHEMBL4569508 |  |
IC50 | < | 10.0 | nM | 529.59 | O=C(NCC(F)(F)F)c1cc(-c2cnn3cc(-c4ccc(OCCN5CCCCC5)cc4)cnc23)cs1 | Homo sapiens | CHEMBL4479731 | assay format |
| CHEMBL3735401 |  |
IC50 | = | 14.0 | nM | 465.56 | CCc1cc2c(cc1-c1cnn(CC(=O)N(C)C)c1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O | Homo sapiens | CHEMBL3748819 | single protein format |
| CHEMBL3393607 |  |
IC50 | = | 14.2 | nM | 493.57 | CN(C)C/C=C/C(=O)Nc1cccc(C(=O)Nc2ccc(Nc3nccc(-c4cccnc4)n3)cc2)c1 | Homo sapiens | CHEMBL4731591 | assay format |
| CHEMBL3746678 |  |
IC50 | = | 15.0 | nM | 465.6 | CCc1cc2c(cc1-c1cnn(CCCN(C)C)c1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O | Homo sapiens | CHEMBL3748819 | single protein format |
| CHEMBL4550702 |  |
IC50 | = | 19.0 | nM | 406.39 | Cn1cc(-c2cnc3c(-c4csc(C(=O)NCC(F)(F)F)c4)cnn3c2)cn1 | Homo sapiens | CHEMBL4479731 | assay format |
| CHEMBL4278882 |  |
IC50 | = | 21.0 | nM | 384.53 | CC(=O)N1CCN([C@H]2CC[C@H](Nc3ncnn4ccc(C(C)C)c34)CC2)CC1 | Homo sapiens | CHEMBL4266498 | cell-based format |
| CHEMBL5176837 |  |
IC50 | = | 22.6 | nM | 389.46 | COc1cc2ncc(-c3cccc(NC4CCNC4)n3)n2cc1-c1cnn(C)c1 | Homo sapiens | CHEMBL5150845 | single protein format |
| CHEMBL4064608 |  |
IC50 | = | 23.0 | nM | 385.51 | c1nc(N[C@H]2CC[C@H](N3CCOCC3)CC2)c2c(C3CCOCC3)c[nH]c2n1 | Homo sapiens | CHEMBL4027011 | cell-based format |
| CHEMBL4784448 |  |
IC50 | = | 25.0 | nM | 452.47 | C=CC(=O)Nc1cccc(C(=O)Nc2cccc(NC(=O)c3cccc(-c4ccn[nH]4)n3)c2)c1 | Homo sapiens | CHEMBL4731589 | single protein format |
| CHEMBL4582624 |  |
IC50 | = | 27.0 | nM | 504.6 | COC(=O)N1CCN([C@H]2CC[C@H](Nc3nc(Nc4cnn(C)c4)nc4ccc(CC#N)nc34)CC2)CC1 | Homo sapiens | CHEMBL4323539 | single protein format |
| CHEMBL2035187 |  |
IC50 | = | 39.5 | nM | 472.59 | C1=N/C2=N/c3ccc(OCCN4CCCC4)c(c3)COC/C=C/COCc3cccc(c3)C(=C1)N2 | Homo sapiens | CHEMBL5224519 | single protein format |
| CHEMBL4455718 |  |
IC50 | = | 44.0 | nM | 394.48 | COC(=O)N1CCN([C@H]2CC[C@H](Nc3ncnc4ccc(C#N)cc34)CC2)CC1 | Homo sapiens | CHEMBL4323539 | single protein format |
| CHEMBL4799481 |  |
IC50 | = | 47.0 | nM | 452.47 | C=CC(=O)Nc1ccc(C(=O)Nc2ccc(NC(=O)c3cccc(-c4ccn[nH]4)n3)cc2)cc1 | Homo sapiens | CHEMBL4731589 | single protein format |
| CHEMBL4790193 |  |
IC50 | = | 52.0 | nM | 509.57 | CN(C)C/C=C/C(=O)Nc1cccc(C(=O)Nc2ccc(NC(=O)c3cccc(-c4ccn[nH]4)n3)cc2)c1 | Homo sapiens | CHEMBL4731589 | single protein format |
| CHEMBL4786242 |  |
IC50 | = | 55.0 | nM | 452.47 | C=CC(=O)Nc1ccc(C(=O)Nc2cccc(NC(=O)c3cccc(-c4ccn[nH]4)n3)c2)cc1 | Homo sapiens | CHEMBL4731589 | single protein format |
| CHEMBL3353219 |  |
IC50 | = | 55.0 | nM | 400.87 | NCC1CCN(c2ccc(Cl)cc2NC(=O)c2cnn3cc(O)cnc23)CC1 | Homo sapiens | CHEMBL3372373 | single protein format |