P51575 | P2RX1_HUMAN | P2X purinoceptor 1 (P2RX1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00864 | P2X_receptor - ATP P2X receptor | 14~369 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL536151 |  |
IC50 | = | 19.2 | nM | 383.68 | O=C(Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(Cl)ccc1O | Homo sapiens | CHEMBL4615154 | cell-based format |
| CHEMBL2338696 |  |
IC50 | = | 23.1 | nM | 383.68 | O=C(Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccc(Cl)cc1O | Homo sapiens | CHEMBL4615154 | cell-based format |
| CHEMBL2179173 |  |
IC50 | = | 29.3 | nM | 316.57 | O=C(Nc1cc(Cl)cc(Cl)c1)c1cc(Cl)ccc1O | Homo sapiens | CHEMBL4615154 | cell-based format |
| CHEMBL4640175 |  |
IC50 | = | 31.6 | nM | 360.68 | O=C(Nc1cc([N+](=O)[O-])cc(C(F)(F)F)c1)c1cc(Cl)ccc1O | Homo sapiens | CHEMBL4615154 | cell-based format |
| CHEMBL2088014 |  |
IC50 | = | 38.3 | nM | 315.68 | O=C(Nc1ccc(C(F)(F)F)cc1)c1cc(Cl)ccc1O | Homo sapiens | CHEMBL4615154 | cell-based format |
| CHEMBL2179174 |  |
IC50 | = | 50.5 | nM | 283.66 | O=C(Nc1cc(F)cc(F)c1)c1cc(Cl)ccc1O | Homo sapiens | CHEMBL4615154 | cell-based format |
| CHEMBL2338695 |  |
IC50 | = | 58.0 | nM | 383.68 | O=C(Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cccc(Cl)c1O | Homo sapiens | CHEMBL4615154 | cell-based format |
| CHEMBL4644398 |  |
IC50 | = | 70.6 | nM | 367.22 | O=C(Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cccc(F)c1O | Homo sapiens | CHEMBL4615154 | cell-based format |
| CHEMBL2088011 |  |
IC50 | = | 75.6 | nM | 282.13 | O=C(Nc1cccc(Cl)c1)c1cc(Cl)ccc1O | Homo sapiens | CHEMBL4615154 | cell-based format |
| CHEMBL461542 |  |
IC50 | = | 76.9 | nM | 349.23 | O=C(Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1O | Homo sapiens | CHEMBL4615154 | cell-based format |
| CHEMBL589733 |  |
IC50 | = | 91.0 | nM | 315.68 | O=C(Nc1cccc(C(F)(F)F)c1)c1cc(Cl)ccc1O | Homo sapiens | CHEMBL4615154 | cell-based format |
| CHEMBL2088009 |  |
IC50 | = | 172.0 | nM | 292.68 | O=C(Nc1cccc([N+](=O)[O-])c1)c1cc(Cl)ccc1O | Homo sapiens | CHEMBL4615154 | cell-based format |
| CHEMBL2088012 |  |
IC50 | = | 199.0 | nM | 282.13 | O=C(Nc1ccc(Cl)cc1)c1cc(Cl)ccc1O | Homo sapiens | CHEMBL4615154 | cell-based format |
| CHEMBL4637528 |  |
IC50 | = | 219.0 | nM | 360.68 | O=C(Nc1cc([N+](=O)[O-])cc(C(F)(F)F)c1)c1cccc(Cl)c1O | Homo sapiens | CHEMBL4615154 | cell-based format |
| CHEMBL2313115 |  |
IC50 | = | 236.0 | nM | 363.26 | Cc1ccc(O)c(C(=O)Nc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c1 | Homo sapiens | CHEMBL4615154 | cell-based format |
| CHEMBL2178702 |  |
IC50 | = | 323.0 | nM | 275.74 | Cc1cc(C)cc(NC(=O)c2cc(Cl)ccc2O)c1 | Homo sapiens | CHEMBL4615154 | cell-based format |
| CHEMBL4648128 |  |
IC50 | = | 335.0 | nM | 379.74 | O=C(Nc1cccc(S(=O)(=O)C(F)(F)F)c1)c1cc(Cl)ccc1O | Homo sapiens | CHEMBL4615154 | cell-based format |
| CHEMBL2338686 |  |
IC50 | = | 341.0 | nM | 399.29 | O=C(Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccc2ccccc2c1O | Homo sapiens | CHEMBL4615154 | cell-based format |
| CHEMBL2313133 |  |
IC50 | = | 439.0 | nM | 419.73 | O=S(=O)(Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(Cl)ccc1O | Homo sapiens | CHEMBL4615154 | cell-based format |
| CHEMBL190141 |  |
IC50 | = | 496.0 | nM | 525.68 | O=C(N[C@H](Cc1cscn1)C(=O)N[C@@H](CC1CCCCC1)[C@@H](O)[C@@H](O)C1CC1)c1nc2ccccc2[nH]1 | Homo sapiens | CHEMBL4615154 | cell-based format |