P51570 | GALK1_HUMAN | Galactokinase (GALK1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00288 | GHMP_kinases_N - GHMP kinases N terminal domain | 108~194 | |
| PF08544 | GHMP_kinases_C - GHMP kinases C terminal | 292~372 | |
| PF10509 | GalKase_gal_bdg - Galactokinase galactose-binding signature | 19~67 |
3D structures mapped by conservation among orthologs
[ Domain: "Ribosomal protein S5 domain 2-like" // GHMP_kinases_N ]
[ Domain: "GHMP Kinase, C-terminal domain" // GHMP_kinases_C ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL1705947 |  |
IC50 | = | 0.0 | nM | 425.54 | O=C1CCCC2=C1C1(CCCC1)N=C(Nc1nc3ccccc3n1Cc1ccccc1)N2 | Homo sapiens | CHEMBL5052897 | single protein format |
| CHEMBL5089592 |  |
IC50 | = | 0.0 | nM | 442.48 | CC1=C(C(=O)Nc2nc3ccccc3o2)C2(CCCC2)N=C(Nc2nc3ccccc3o2)N1 | Homo sapiens | CHEMBL5052897 | single protein format |
| CHEMBL3899970 |  |
IC50 | = | 0.0 | nM | 427.26 | O=C1CCCC2=C1C(c1n[nH]cc1Br)N=C(Nc1nc3ccccc3o1)N2 | Homo sapiens | CHEMBL5052897 | single protein format |
| CHEMBL1393992 |  |
IC50 | = | 0.0 | nM | 364.45 | CCC1CCC2(C1)N=C(Nc1nc3ccccc3o1)NC1=C2C(=O)CCC1 | Homo sapiens | CHEMBL5052897 | single protein format |
| CHEMBL5084931 |  |
IC50 | = | 0.0 | nM | 502.92 | CC1=C(C(=O)Nc2noc3ccccc23)C(c2nn(C)cc2Cl)N=C(Nc2nc3ccccc3o2)N1 | Homo sapiens | CHEMBL5052897 | single protein format |
| CHEMBL5088290 |  |
IC50 | = | 50.0 | nM | 522.97 | CC1=C(C(=O)NCc2cnn(C)c2)C(c2ccc(C)cc2Cl)N=C(Nc2nc3ccc(F)c(N)c3o2)N1 | Homo sapiens | CHEMBL5051778 | single protein format |
| CHEMBL5073602 |  |
IC50 | = | 50.0 | nM | 537.0 | CCn1cc(CNC(=O)C2=C(C)NC(Nc3nc4ccc(F)c(N)c4o3)=NC2c2ccc(C)cc2Cl)cn1 | Homo sapiens | CHEMBL5051778 | single protein format |
| CHEMBL5092879 |  |
IC50 | = | 50.0 | nM | 533.04 | CCn1cc(C(C)NC(=O)C2=C(C)NC(Nc3nc4cccc(N)c4o3)=NC2c2ccc(C)cc2Cl)cn1 | Homo sapiens | CHEMBL5051778 | single protein format |
| CHEMBL5087686 |  |
IC50 | = | 70.0 | nM | 537.0 | CCn1cc(CNC(=O)C2=C(C)NC(Nc3nc4ccc(F)c(N)c4o3)=N[C@H]2c2ccc(C)cc2Cl)cn1 | Homo sapiens | CHEMBL5051778 | single protein format |
| CHEMBL5078070 |  |
IC50 | = | 86.0 | nM | 517.93 | CC1=C(C(=O)Nc2cc(C(=O)O)ccn2)[C@H](c2ccccc2Cl)N=C(Nc2nc3cccc(N)c3o2)N1 | Homo sapiens | CHEMBL5051778 | single protein format |
| CHEMBL5078166 |  |
IC50 | = | 90.0 | nM | 531.96 | CC1=C(C(=O)Nc2cc(C(=O)O)ccn2)[C@H](c2ccc(C)cc2Cl)N=C(Nc2nc3cccc(N)c3o2)N1 | Homo sapiens | CHEMBL5051778 | single protein format |
| CHEMBL5092268 |  |
IC50 | = | 110.0 | nM | 554.99 | CCn1ncc(CNC(=O)C2=C(C)NC(Nc3nc4ccc(F)c(N)c4o3)=NC2c2ccc(C)cc2Cl)c1F | Homo sapiens | CHEMBL5051778 | single protein format |
| CHEMBL5072646 |  |
IC50 | = | 120.0 | nM | 586.97 | CC1=C(C(=O)Nc2cc(C(=O)O)ccn2)C(c2ccc(-n3ccnc3)cc2Cl)N=C(Nc2nc3ccc(F)cc3o2)N1 | Homo sapiens | CHEMBL5051778 | single protein format |
| CHEMBL5092901 |  |
IC50 | = | 120.0 | nM | 531.96 | CC1=C(C(=O)Nc2cc(C(=O)O)ccn2)C(c2ccc(C)cc2Cl)N=C(Nc2nc3cccc(N)c3o2)N1 | Homo sapiens | CHEMBL5051778 | single protein format |
| CHEMBL5075869 |  |
IC50 | = | 130.0 | nM | 504.98 | CC1=C(C(=O)NCc2cnn(C)c2)[C@H](c2ccc(C)cc2Cl)N=C(Nc2nc3cccc(N)c3o2)N1 | Homo sapiens | CHEMBL5051778 | single protein format |
| CHEMBL5086925 |  |
IC50 | = | 140.0 | nM | 547.96 | COc1ccc(C2N=C(Nc3nc4cccc(N)c4o3)NC(C)=C2C(=O)Nc2cc(C(=O)O)ccn2)c(Cl)c1 | Homo sapiens | CHEMBL5051778 | single protein format |
| CHEMBL5082388 |  |
IC50 | = | 150.0 | nM | 534.94 | CC1=C(C(=O)Nc2cc(C(=O)O)ccn2)[C@H](c2ccc(C)cc2Cl)N=C(Nc2nc3ccc(F)cc3o2)N1 | Homo sapiens | CHEMBL5051778 | single protein format |
| CHEMBL5078058 |  |
IC50 | = | 150.0 | nM | 547.96 | COc1ccc([C@@H]2N=C(Nc3nc4cccc(N)c4o3)NC(C)=C2C(=O)Nc2cc(C(=O)O)ccn2)c(Cl)c1 | Homo sapiens | CHEMBL5051778 | single protein format |
| CHEMBL5077147 |  |
IC50 | = | 170.0 | nM | 519.01 | CCn1cc(CNC(=O)C2=C(C)NC(Nc3nc4cccc(N)c4o3)=NC2c2ccc(C)cc2Cl)cn1 | Homo sapiens | CHEMBL5051778 | single protein format |
| CHEMBL5094940 |  |
IC50 | = | 190.0 | nM | 590.97 | CC1=C(C(=O)NCc2cnn(CC(F)(F)F)c2)C(c2ccc(C)cc2Cl)N=C(Nc2nc3ccc(F)c(N)c3o2)N1 | Homo sapiens | CHEMBL5051778 | single protein format |