P51532 | SMCA4_HUMAN | Transcription activator BRG1 (SMARCA4)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00176 | SNF2-rel_dom - SNF2-related domain | 757~1051 | |
| PF00271 | Helicase_C - Helicase conserved C-terminal domain | 1081~1194 | |
| PF00439 | Bromodomain - Bromodomain | 1478~1549 | |
| PF07529 | HSA - HSA domain | 462~531 | |
| PF07533 | BRK - BRK domain | 611~654 | |
| PF08880 | QLQ - QLQ | 171~205 | |
| PF14619 | SnAC - Snf2-ATP coupling, chromatin remodelling complex | 1322~1389 |
3D structures mapped by conservation among orthologs
[ Domain: "Bromodomain" // Bromodomain ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4295096 |  |
IC50 | < | 5.0 | nM | 318.28 | O=C(Nc1cc(C(F)F)ns1)Nc1cc(F)ncc1CO | Homo sapiens | CHEMBL4276234 | cell-based format |
| CHEMBL4282980 |  |
IC50 | < | 5.0 | nM | 303.27 | Nc1cnc(F)cc1NC(=O)Nc1cc(C(F)F)ns1 | Homo sapiens | CHEMBL4276234 | cell-based format |
| CHEMBL4293567 |  |
IC50 | < | 5.0 | nM | 334.74 | O=C(Nc1cc(C(F)F)ns1)Nc1cc(Cl)ncc1CO | Homo sapiens | CHEMBL4276234 | cell-based format |
| CHEMBL4286345 |  |
IC50 | < | 5.0 | nM | 319.72 | Nc1cnc(Cl)cc1NC(=O)Nc1cc(C(F)F)ns1 | Homo sapiens | CHEMBL4276234 | cell-based format |
| CHEMBL4278436 |  |
IC50 | = | 6.0 | nM | 304.71 | O=C(Nc1ccnc(Cl)c1)Nc1cc(C(F)F)ns1 | Homo sapiens | CHEMBL4276234 | cell-based format |
| CHEMBL4294655 |  |
IC50 | = | 10.0 | nM | 322.7 | O=C(Nc1ccnc(Cl)c1)Nc1cc(C(F)(F)F)ns1 | Homo sapiens | CHEMBL4276234 | cell-based format |
| CHEMBL4286757 |  |
IC50 | = | 30.0 | nM | 268.73 | Cc1cc(NC(=O)Nc2ccnc(Cl)c2)sn1 | Homo sapiens | CHEMBL4276234 | cell-based format |
| CHEMBL4290175 |  |
IC50 | = | 30.0 | nM | 316.67 | O=C(Nc1ccnc(Cl)c1)Nc1ccnc(C(F)(F)F)c1 | Homo sapiens | CHEMBL4276234 | cell-based format |
| CHEMBL5177096 |  |
IC50 | = | 30.0 | nM | 263.3 | Nc1nnc(-c2ccccc2O)cc1-c1ccccc1 | Homo sapiens | CHEMBL5142210 | single protein format |
| CHEMBL5207330 |  |
IC50 | = | 35.0 | nM | 327.39 | CC(=O)N1CCN(c2cc(-c3ccccc3O)nnc2N)C[C@H]1C | Homo sapiens | CHEMBL5142210 | single protein format |
| CHEMBL4281368 |  |
IC50 | = | 150.0 | nM | 262.7 | Cc1cc(NC(=O)Nc2ccnc(Cl)c2)ccn1 | Homo sapiens | CHEMBL4276234 | cell-based format |
| CHEMBL3752911 |  |
IC50 | = | 410.5 | nM | 321.38 | O=C(/C=C/N1C[C@H]2C[C@@H]1CN2c1ccccn1)c1ccccc1O | Homo sapiens | CHEMBL4650020 | single protein format |
| CHEMBL4746865 |  |
IC50 | = | 550.0 | nM | 271.32 | Nc1nnc(-c2ccccc2O)cc1N1CCNCC1 | Homo sapiens | CHEMBL5231298 | single protein format |
| CHEMBL4282784 |  |
IC50 | = | 570.0 | nM | 268.73 | Cc1csc(NC(=O)Nc2ccnc(Cl)c2)n1 | Homo sapiens | CHEMBL4276234 | cell-based format |
| CHEMBL4290675 |  |
IC50 | = | 770.0 | nM | 248.67 | O=C(Nc1ccncc1)Nc1ccnc(Cl)c1 | Homo sapiens | CHEMBL4276234 | cell-based format |