P51531 | SMCA2_HUMAN | Probable global transcription activator SNF2L2 (SMARCA2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00176 | SNF2-rel_dom - SNF2-related domain | 727~1021 | |
| PF00271 | Helicase_C - Helicase conserved C-terminal domain | 1051~1164 | |
| PF00439 | Bromodomain - Bromodomain | 1419~1491 | |
| PF07529 | HSA - HSA domain | 438~507 | |
| PF07533 | BRK - BRK domain | 589~632 | |
| PF08880 | QLQ - QLQ | 173~207 | |
| PF14619 | SnAC - Snf2-ATP coupling, chromatin remodelling complex | 1259~1326 |
3D structures mapped by conservation among orthologs
[ Domain: "Bromodomain" // Bromodomain ]
[ Domain: "P-loop containing nucleoside triphosphate hydrolases" // SNF2_N ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4278436 |  |
IC50 | = | 5.0 | nM | 304.71 | O=C(Nc1ccnc(Cl)c1)Nc1cc(C(F)F)ns1 | Homo sapiens | CHEMBL4276233 | cell-based format |
| CHEMBL4295096 |  |
IC50 | < | 5.0 | nM | 318.28 | O=C(Nc1cc(C(F)F)ns1)Nc1cc(F)ncc1CO | Homo sapiens | CHEMBL4276233 | cell-based format |
| CHEMBL4282980 |  |
IC50 | < | 5.0 | nM | 303.27 | Nc1cnc(F)cc1NC(=O)Nc1cc(C(F)F)ns1 | Homo sapiens | CHEMBL4276233 | cell-based format |
| CHEMBL4293567 |  |
IC50 | < | 5.0 | nM | 334.74 | O=C(Nc1cc(C(F)F)ns1)Nc1cc(Cl)ncc1CO | Homo sapiens | CHEMBL4276233 | cell-based format |
| CHEMBL4286345 |  |
IC50 | < | 5.0 | nM | 319.72 | Nc1cnc(Cl)cc1NC(=O)Nc1cc(C(F)F)ns1 | Homo sapiens | CHEMBL4276233 | cell-based format |
| CHEMBL4294655 |  |
IC50 | = | 10.0 | nM | 322.7 | O=C(Nc1ccnc(Cl)c1)Nc1cc(C(F)(F)F)ns1 | Homo sapiens | CHEMBL4276233 | cell-based format |
| CHEMBL4286757 |  |
IC50 | = | 33.0 | nM | 268.73 | Cc1cc(NC(=O)Nc2ccnc(Cl)c2)sn1 | Homo sapiens | CHEMBL4276233 | cell-based format |
| CHEMBL5177096 |  |
IC50 | = | 37.0 | nM | 263.3 | Nc1nnc(-c2ccccc2O)cc1-c1ccccc1 | Homo sapiens | CHEMBL5142211 | single protein format |
| CHEMBL4290175 |  |
IC50 | = | 60.0 | nM | 316.67 | O=C(Nc1ccnc(Cl)c1)Nc1ccnc(C(F)(F)F)c1 | Homo sapiens | CHEMBL4276233 | cell-based format |
| CHEMBL4279505 |  |
IC50 | = | 110.0 | nM | 298.68 | O=C(Nc1ccnc(Cl)c1)Nc1ccnc(C(F)F)c1 | Homo sapiens | CHEMBL4276233 | cell-based format |
| CHEMBL4281368 |  |
IC50 | = | 200.0 | nM | 262.7 | Cc1cc(NC(=O)Nc2ccnc(Cl)c2)ccn1 | Homo sapiens | CHEMBL4276233 | cell-based format |
| CHEMBL4746865 |  |
IC50 | = | 370.0 | nM | 271.32 | Nc1nnc(-c2ccccc2O)cc1N1CCNCC1 | Homo sapiens | CHEMBL5231297 | single protein format |
| CHEMBL4282784 |  |
IC50 | = | 970.0 | nM | 268.73 | Cc1csc(NC(=O)Nc2ccnc(Cl)c2)n1 | Homo sapiens | CHEMBL4276233 | cell-based format |
| CHEMBL4063051 |  |
IC50 | = | 1000.0 | nM | 410.5 | Cc1[nH]c(-c2cc(NS(C)(=O)=O)ccc2Oc2ccccc2)c2c1C(=O)CCC2 | Homo sapiens | CHEMBL4038409 | assay format |