P51452 | DUS3_HUMAN | Dual specificity protein phosphatase 3 (DUSP3)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00782 | DSPc - Dual specificity phosphatase, catalytic domain | 37~175 |
3D structures mapped by conservation among orthologs
[ Domain: "(Phosphotyrosine protein) phosphatases II" // DSPc ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL584481 |  |
IC50 | = | 74.0 | nM | 595.7 | O=C1/C(=C/c2cn(-c3ccccc3)nc2-c2ccc(OCc3ccccc3F)cc2)SC(=S)N1CCS(=O)(=O)O | Homo sapiens | CHEMBL1047966 | single protein format |
| CHEMBL565810 |  |
IC50 | = | 78.0 | nM | 577.71 | O=C1/C(=C/c2cn(-c3ccccc3)nc2-c2ccc(OCc3ccccc3)cc2)SC(=S)N1CCS(=O)(=O)O | Homo sapiens | CHEMBL1047966 | single protein format |
| CHEMBL1460470 |  |
IC50 | = | 121.0 | nM | 382.89 | NS(=O)(=O)c1cc(C(=O)NC2CCSc3ccccc32)ccc1Cl | Homo sapiens | CHEMBL1738088 | single protein format |
| CHEMBL1608642 |  |
IC50 | = | 127.0 | nM | 251.35 | COc1cc(C(=S)N2CCCCC2)ccc1O | Homo sapiens | CHEMBL1738181 | single protein format |
| CHEMBL1448629 |  |
IC50 | = | 181.0 | nM | 392.67 | O=c1/c(=C/c2ccccc2Cl)sc2nc3cc(Br)cnc3n12 | Homo sapiens | CHEMBL1738181 | single protein format |
| CHEMBL1705741 |  |
IC50 | = | 220.0 | nM | 359.34 | COc1cc(C(=S)NCc2ccc(F)c(C(F)(F)F)c2)ccc1O | Homo sapiens | CHEMBL1738181 | single protein format |
| CHEMBL1605172 |  |
IC50 | = | 250.0 | nM | 348.5 | Cc1ccc(-n2c(N)c(C(=O)N3CCN(C)CC3)sc2=S)cc1 | Homo sapiens | CHEMBL1738088 | single protein format |
| CHEMBL1371869 |  |
IC50 | = | 308.0 | nM | 468.29 | O=C(O)c1ccccc1-c1ccc(/C=c2\sc3nc4cc(Br)cnc4n3c2=O)o1 | Homo sapiens | CHEMBL1738181 | single protein format |
| CHEMBL1408579 |  |
IC50 | = | 342.0 | nM | 325.26 | S=C(NCCc1ccccc1)Nc1c(Cl)cccc1Cl | Homo sapiens | CHEMBL1738088 | single protein format |
| CHEMBL1603381 |  |
IC50 | = | 345.0 | nM | 348.18 | O=c1/c(=C/c2ccco2)sc2nc3cc(Br)cnc3n12 | Homo sapiens | CHEMBL1738181 | single protein format |
| CHEMBL1727679 |  |
IC50 | = | 408.0 | nM | 301.41 | COc1cc(C(=S)NCc2ccc(C)cc2C)ccc1O | Homo sapiens | CHEMBL1738181 | single protein format |
| CHEMBL1304193 |  |
IC50 | = | 530.0 | nM | 334.47 | CN1CCN(C(=O)c2sc(=S)n(-c3ccccc3)c2N)CC1 | Homo sapiens | CHEMBL1738088 | single protein format |
| CHEMBL1608654 |  |
IC50 | = | 680.0 | nM | 416.46 | Cc1cc(C)c2nc3s/c(=C\c4ccc(-c5ccccc5C(=O)O)o4)c(=O)n3c2c1 | Homo sapiens | CHEMBL1738181 | single protein format |
| CHEMBL1322542 |  |
IC50 | = | 704.0 | nM | 313.45 | NS(=O)(=O)c1ccc(NC(S)=NC2CCCCC2)cc1 | Homo sapiens | CHEMBL1738088 | single protein format |
| CHEMBL1407203 |  |
IC50 | = | 727.0 | nM | 350.49 | S=C(c1cn(CCOc2ccccc2)c2ccccc12)N1CCCC1 | Homo sapiens | CHEMBL1738088 | single protein format |
| CHEMBL2316908 |  |
IC50 | = | 800.0 | nM | 446.46 | O=C(O)c1cc2c(C#Cc3ccc(Oc4ccccc4)cc3)c(-c3ccccc3)oc2cc1O | Homo sapiens | CHEMBL2321067 | assay format |
| CHEMBL1414679 |  |
IC50 | = | 967.0 | nM | 527.0 | CC1=C(C(=O)OC(C)C)C(c2ccc(Cl)cc2)n2c(sc(=Cc3ccc(OCC(=O)O)cc3)c2=O)=N1 | Homo sapiens | CHEMBL1738088 | single protein format |
| CHEMBL578512 |  |
IC50 | < | 980.0 | nM | 193.17 | Cn1ncnc2c(=O)n(C)c(=O)nc1-2 | Homo sapiens | CHEMBL1613889 | single protein format |
| CHEMBL66953 |  |
IC50 | < | 980.0 | nM | 220.18 | O=c1c(O)cccc2cc(O)c(O)c(O)c12 | Homo sapiens | CHEMBL1613889 | single protein format |
| CHEMBL570345 |  |
IC50 | < | 980.0 | nM | 306.32 | O=C(c1cccs1)c1no[n+]([O-])c1C(=O)c1cccs1 | Homo sapiens | CHEMBL1613889 | single protein format |