P51160 | PDE6C_HUMAN | Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' (PDE6C)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00233 | PDEase_I - 3'5'-cyclic nucleotide phosphodiesterase | 561~803 | |
| PF01590 | GAF - GAF domain | 77~223 | |
| PF01590 | GAF - GAF domain | 256~432 |
3D structures mapped by conservation among orthologs
[ Domain: "HD-domain/PDEase-like" // PDEase_I ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3936651 |  |
IC50 | = | 0.13 | nM | 534.58 | CCOc1ccc(OC2CCN(c3ncc(C(=O)NO)cn3)CC2)cc1-c1nc2c(CC)nn(C)c2c(=O)[nH]1 | Homo sapiens | CHEMBL3861027 | cell-based format |
| CHEMBL377168 |  |
IC50 | = | 0.9 | nM | 354.41 | CCCc1nn(C)c2c(O)nc(-c3cc(C(C)=O)ccc3OCC)nc12 | Homo sapiens | CHEMBL860111 | single protein format |
| CHEMBL4217054 |  |
IC50 | = | 1.2 | nM | 451.56 | CCc1ccc([C@@H]2c3[nH]c4ccccc4c(=O)c3CN2c2ncc(-c3ccccn3)cn2)s1 | Homo sapiens | CHEMBL4198222 | cell-based format |
| CHEMBL4218772 |  |
IC50 | = | 1.2 | nM | 491.53 | COCCNc1cc(O)c2c(=O)c3c(-c4nccs4)[nH]c(Cc4ccc5c(c4)OCO5)c3oc2c1 | Homo sapiens | CHEMBL4200912 | assay format |
| CHEMBL209460 |  |
IC50 | = | 1.4 | nM | 439.52 | CCCc1nn(C)c2c(O)nc(-c3cc(C(=O)CN4CCOCC4)ccc3OCC)nc12 | Homo sapiens | CHEMBL860111 | single protein format |
| CHEMBL4212186 |  |
IC50 | = | 1.4 | nM | 467.55 | CCCc1nn(C)c2c(=O)[nH]c(-c3cc(Cc4ccc(C(=O)NO)s4)ccc3OCC)nc12 | Homo sapiens | CHEMBL4198940 | single protein format |
| CHEMBL4217579 |  |
IC50 | = | 1.5 | nM | 435.49 | CCc1ccc([C@@H]2c3[nH]c4ccccc4c(=O)c3CN2c2ncc(-c3ccccn3)cn2)o1 | Homo sapiens | CHEMBL4198222 | cell-based format |
| CHEMBL4212630 |  |
IC50 | = | 2.3 | nM | 435.49 | CCc1ccc(C2c3[nH]c4ccccc4c(=O)c3CN2c2ncc(-c3ccccn3)cn2)o1 | Homo sapiens | CHEMBL4198222 | cell-based format |
| CHEMBL3900593 |  |
IC50 | = | 2.6 | nM | 425.49 | CCOc1ccc(CC2CC(C(=O)NO)C2)cc1-c1nc2c(CC)nn(C)c2c(=O)[nH]1 | Homo sapiens | CHEMBL3861027 | cell-based format |
| CHEMBL4218398 |  |
IC50 | = | 3.7 | nM | 374.47 | CCc1ccc(C2c3[nH]c4ccccc4c(=O)c3CN2c2ncccn2)s1 | Homo sapiens | CHEMBL4198222 | cell-based format |
| CHEMBL4208249 |  |
IC50 | = | 3.8 | nM | 435.49 | CCc1ccc([C@H]2c3[nH]c4ccccc4c(=O)c3CN2c2ncc(-c3ccccn3)cn2)o1 | Homo sapiens | CHEMBL4198222 | cell-based format |
| CHEMBL4209716 |  |
IC50 | = | 4.8 | nM | 451.56 | CCc1ccc(C2c3[nH]c4ccccc4c(=O)c3CN2c2ncc(-c3ccccn3)cn2)s1 | Homo sapiens | CHEMBL4198222 | cell-based format |
| CHEMBL3401745 |  |
IC50 | = | 5.2 | nM | 491.61 | CCCc1nn(C)c2c(=O)[nH]c(-c3cc(S(=O)(=O)NCCCCCCO)ccc3OCC)nc12 | Homo sapiens | CHEMBL3405817 | single protein format |
| CHEMBL4204725 |  |
IC50 | = | 6.2 | nM | 358.4 | CCc1ccc(C2c3[nH]c4ccccc4c(=O)c3CN2c2ncccn2)o1 | Homo sapiens | CHEMBL4198222 | cell-based format |
| CHEMBL4072903 |  |
IC50 | = | 6.6 | nM | 406.87 | CCN1Cc2nc3ccc(C#N)cc3c(NCc3ccc(OC)c(Cl)c3)c2C1=O | Homo sapiens | CHEMBL4020496 | single protein format |
| CHEMBL4284224 |  |
IC50 | = | 10.0 | nM | 363.42 | CCc1ccc([C@H]2c3[nH]c4ccccc4c3C[C@@H]3C(=O)N(CC)C(=O)N23)o1 | Homo sapiens | CHEMBL4268480 | cell-based format |
| CHEMBL4285199 |  |
IC50 | = | 13.0 | nM | 365.46 | CCN1C(=O)[C@@H]2Cc3c([nH]c4ccccc34)[C@@H](c3sccc3C)N2C1=O | Homo sapiens | CHEMBL4268480 | cell-based format |
| CHEMBL4062273 |  |
IC50 | = | 30.1 | nM | 420.9 | COc1ccc(CNc2c3c(nc4ccc(C#N)cc24)CCN(C(C)=O)C3)cc1Cl | Homo sapiens | CHEMBL4020496 | single protein format |
| CHEMBL4205338 |  |
IC50 | = | 34.1 | nM | 451.56 | CCc1ccc([C@H]2c3[nH]c4ccccc4c(=O)c3CN2c2ncc(-c3ccccn3)cn2)s1 | Homo sapiens | CHEMBL4198222 | cell-based format |
| CHEMBL2180945 |  |
IC50 | = | 45.6 | nM | 448.59 | CCCOc1ccc(S(=O)(=O)N2CCN(C)CC2)cc1-c1nc(CC)c(CC)c(=O)[nH]1 | Homo sapiens | CHEMBL2184506 | single protein format |