P50613 | CDK7_HUMAN | Cyclin-dependent kinase 7 (CDK7)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 12~295 |
3D structures mapped by conservation among orthologs
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4562323 |  |
IC50 | = | 0.13 | nM | 432.53 | CC(C)c1cnn2c(NCc3ccccc3-n3cccn3)nc(OC3CCCNC3)nc12 | Homo sapiens | CHEMBL4403338 | single protein format |
| CHEMBL4754493 |  |
IC50 | = | 1.3 | nM | 360.89 | Cn1ncc(-c2nc(N[C@H]3CC[C@H](N)CC3)ncc2Cl)c1CC1CC1 | Homo sapiens | CHEMBL5224429 | single protein format |
| CHEMBL3603847 |  |
IC50 | = | 3.2 | nM | 566.07 | CN(C)C/C=C/C(=O)Nc1ccc(C(=O)Nc2cccc(Nc3ncc(Cl)c(-c4c[nH]c5ccccc45)n3)c2)cc1 | Homo sapiens | CHEMBL3606990 | single protein format |
| CHEMBL5196685 |  |
IC50 | = | 3.2 | nM | 566.07 | CN(C)/C=C/CC(=O)Nc1ccc(C(=O)Nc2cccc(Nc3ncc(Cl)c(-c4cc5ccccc5[nH]4)n3)c2)cc1 | Homo sapiens | CHEMBL5123402 | single protein format |
| CHEMBL5288241 |  |
IC50 | = | 4.0 | nM | 518.58 | C=CC(=O)Nc1ccc(C(=O)Nc2n[nH]c3ccc(-c4cncc(NC[C@@H](O)c5ccccc5)c4)cc23)cc1 | Homo sapiens | CHEMBL5238222 | single protein format |
| CHEMBL4568087 |  |
IC50 | = | 4.1 | nM | 421.53 | Cn1cc(-c2cnc3c(-c4csc(C(=O)N[C@@H]5CCCC[C@@H]5N)c4)cnn3c2)cn1 | Homo sapiens | CHEMBL4479705 | assay format |
| CHEMBL5269885 |  |
IC50 | = | 5.0 | nM | 532.6 | C=CC(=O)Nc1ccc(C(=O)Nc2n[nH]c3ccc(-c4cncc(N[C@H](CO)Cc5ccccc5)c4)cc23)cc1 | Homo sapiens | CHEMBL5238222 | single protein format |
| CHEMBL4454044 |  |
IC50 | < | 5.0 | nM | 423.57 | CC(C)c1cnn2c(NCc3ccccc3N(C)C)nc(OC3CCN(C)CC3)nc12 | Homo sapiens | CHEMBL4403338 | single protein format |
| CHEMBL4644572 |  |
IC50 | < | 5.0 | nM | 432.53 | CC(C)c1cnn2c(NCc3ccccc3-n3cccn3)nc(O[C@H]3CCCNC3)nc12 | Homo sapiens | CHEMBL4611854 | single protein format |
| CHEMBL4440386 |  |
IC50 | < | 5.0 | nM | 420.52 | CC(C)c1cnn2c(NCc3cccc4c3cnn4C)nc(OC3CCCNC3)nc12 | Homo sapiens | CHEMBL4403338 | single protein format |
| CHEMBL4552441 |  |
IC50 | < | 5.0 | nM | 406.49 | CC(C)c1cnn2c(NCc3cccc4[nH]ncc34)nc(OC3CCCNC3)nc12 | Homo sapiens | CHEMBL4403338 | single protein format |
| CHEMBL5286683 |  |
IC50 | = | 6.0 | nM | 518.58 | C=CC(=O)Nc1ccc(C(=O)Nc2n[nH]c3ccc(-c4cncc(NC[C@H](O)c5ccccc5)c4)cc23)cc1 | Homo sapiens | CHEMBL5238222 | single protein format |
| CHEMBL5274920 |  |
IC50 | = | 7.0 | nM | 545.6 | C=CC(=O)Nc1ccc(C(=O)Nc2n[nH]c3ccc(-c4cncc(NC(=O)[C@@H](N)Cc5ccccc5)c4)cc23)cc1 | Homo sapiens | CHEMBL5238222 | single protein format |
| CHEMBL4552628 |  |
IC50 | < | 10.0 | nM | 425.89 | Cc1sc(C(=O)N[C@@H]2[C@H](N)CCCC2(F)F)cc1-c1cnn2cc(Cl)cnc12 | Homo sapiens | CHEMBL4479705 | assay format |
| CHEMBL5275973 |  |
IC50 | = | 10.0 | nM | 249.7 | Cl.O=C1NCCc2[nH]c(-c3ccncc3)cc21 | Homo sapiens | CHEMBL5224416 | single protein format |
| CHEMBL1230607 |  |
IC50 | = | 10.0 | nM | 361.49 | CC(C)CC(=O)Nc1n[nH]c2c1CN(C(=O)C1CCN(C)CC1)C2(C)C | Homo sapiens | CHEMBL5230722 | single protein format |
| CHEMBL374413 |  |
IC50 | = | 11.0 | nM | 357.42 | N#Cc1ccc2c(-c3cc4cc(CN5CCOCC5)ccc4[nH]3)n[nH]c2c1 | Homo sapiens | CHEMBL855123 | single protein format |
| CHEMBL4784656 |  |
IC50 | = | 12.0 | nM | 389.46 | C#CC(=O)N1CC=C(c2ccc(C(C)C(=O)Nc3cc(C4CC4)[nH]n3)cn2)CC1 | Homo sapiens | CHEMBL4742552 | single protein format |
| CHEMBL4648392 |  |
IC50 | < | 15.0 | nM | 560.66 | C=CC(=O)Nc1ccc(C(=O)Nc2cc3cc(c2)Nc2nccc(n2)-c2cccc(c2)OCC/C=C/CN(C)C3)cc1 | Homo sapiens | CHEMBL4611854 | single protein format |
| CHEMBL5207274 |  |
IC50 | = | 17.4 | nM | 587.13 | CN(C)/C=C/CC(=O)Nc1ccc(C(=O)N[C@@]2(C)CCC[C@@H](Nc3ncc(Cl)c(-c4c[nH]c5ccccc45)n3)C2)nc1 | Homo sapiens | CHEMBL5123404 | single protein format |