P50416 | CPT1A_HUMAN | Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00755 | Carn_acyltransf - Choline/Carnitine o-acyltransferase | 174~756 | |
| PF16484 | CPT_N - Carnitine O-palmitoyltransferase N-terminus | 1~47 |
3D structures mapped by conservation among orthologs
[ Domain: "N-terminal regulatory segment of carnitine palmitoyltransferase 1A" // CPT_N ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3431816 |  |
IC50 | = | 7.1 | nM | 512.97 | COc1ccc(Cl)cc1S(=O)(=O)c1cn(CCC(=O)O)c2ccc(C(=O)Nc3ccccc3)cc12 | Homo sapiens | CHEMBL3431933 | assay format |
| CHEMBL3431624 |  |
IC50 | = | 11.6 | nM | 540.04 | COc1ccc(Cl)cc1S(=O)(=O)N1CCSc2ccc(C(=O)Nc3nc(CC(=O)O)cs3)cc21 | Homo sapiens | CHEMBL3431933 | assay format |
| CHEMBL3431814 |  |
IC50 | = | 12.8 | nM | 497.96 | COc1ccc(Cl)cc1S(=O)(=O)c1cn(CC(N)=O)c2ccc(C(=O)Nc3ccccc3)cc12 | Homo sapiens | CHEMBL3431933 | assay format |
| CHEMBL3431540 |  |
IC50 | = | 13.2 | nM | 418.45 | O=C1Cc2cc(-c3noc([C@H]4CCCCN4C(=O)COc4ccccc4)n3)ccc2N1 | Homo sapiens | CHEMBL3431933 | assay format |
| CHEMBL3431837 |  |
IC50 | = | 14.7 | nM | 513.96 | COc1ccc(Cl)cc1S(=O)(=O)c1nn(CCC(=O)O)c2ccc(C(=O)Nc3ccccc3)cc12 | Homo sapiens | CHEMBL3431933 | assay format |
| CHEMBL3431830 |  |
IC50 | = | 15.15 | nM | 527.0 | COc1ccc(Cl)cc1S(=O)(=O)c1cn(CCCC(=O)O)c2ccc(C(=O)Nc3ccccc3)cc12 | Homo sapiens | CHEMBL3431933 | assay format |
| CHEMBL2216778 |  |
IC50 | = | 16.0 | nM | 520.92 | COc1ccc(Cl)cc1S(=O)(=O)N1CC(C(=O)O)Oc2ccc(C(=O)Nc3cccc(F)c3)cc21 | Homo sapiens | CHEMBL2217072 | single protein format |
| CHEMBL3431629 |  |
IC50 | = | 16.7 | nM | 454.89 | O=C(O)c1ccc(NC(=O)c2ccc3ccn(S(=O)(=O)c4cccc(Cl)c4)c3c2)cc1 | Homo sapiens | CHEMBL3431933 | assay format |
| CHEMBL3431752 |  |
IC50 | = | 16.7 | nM | 471.56 | Cc1cc(C)cc(S(=O)(=O)N2CCc3ccc(C(=O)Nc4nc(CC(=O)O)cs4)cc32)c1 | Homo sapiens | CHEMBL3431933 | assay format |
| CHEMBL3431919 |  |
IC50 | = | 17.5 | nM | 484.92 | COc1ccc(Cl)cc1S(=O)(=O)c1c[nH]c2ccc(C(=O)Nc3ccc(C(=O)O)cc3)cc12 | Homo sapiens | CHEMBL3431933 | assay format |
| CHEMBL3431533 |  |
IC50 | = | 18.6 | nM | 484.93 | COc1ccc(Cl)cc1S(=O)(=O)Nc1cccc(C(=O)Nc2ccc(-c3nnn[nH]3)cc2)c1 | Homo sapiens | CHEMBL3431933 | assay format |
| CHEMBL3431642 |  |
IC50 | = | 18.8 | nM | 468.92 | Cn1cc(S(=O)(=O)c2cccc(Cl)c2)c2cc(C(=O)Nc3ccc(C(=O)O)cc3)ccc21 | Homo sapiens | CHEMBL3431933 | assay format |
| CHEMBL3431820 |  |
IC50 | = | 19.3 | nM | 522.0 | COc1ccc(Cl)cc1S(=O)(=O)N1CCc2c(C)cc(C(=O)Nc3nc(CC(=O)O)cs3)cc21 | Homo sapiens | CHEMBL3431933 | assay format |
| CHEMBL3431807 |  |
IC50 | = | 19.65 | nM | 444.49 | O=C([O-])c1cccc(-c2csc([C@H]3CCCCN3C(=O)COc3ccccc3)n2)c1.[Na+] | Homo sapiens | CHEMBL3431933 | assay format |
| CHEMBL2216774 |  |
IC50 | = | 20.0 | nM | 379.49 | O=C(COc1ccccc1)N1CCCC[C@@H]1c1nc(-c2ccccn2)cs1 | Homo sapiens | CHEMBL2217072 | single protein format |
| CHEMBL3431514 |  |
IC50 | = | 20.1 | nM | 454.9 | O=C(Nc1ccc(-c2nnn[nH]2)cc1)c1cccc(NS(=O)(=O)c2cccc(Cl)c2)c1 | Homo sapiens | CHEMBL3431933 | assay format |
| CHEMBL3431845 |  |
IC50 | = | 20.8 | nM | 500.96 | COc1ccc(Cl)cc1S(=O)(=O)N1CC(C(=O)O)Cc2ccc(C(=O)Nc3ccccc3)cc21 | Homo sapiens | CHEMBL3431933 | assay format |
| CHEMBL2216779 |  |
IC50 | = | 21.0 | nM | 486.93 | COc1ccc(Cl)cc1S(=O)(=O)N1CCc2ccc(C(=O)Nc3ccc(C(=O)O)cc3)cc21 | Homo sapiens | CHEMBL2217072 | single protein format |
| CHEMBL3431634 |  |
IC50 | = | 21.9 | nM | 498.94 | COc1ccc(Cl)cc1S(=O)(=O)c1c[nH]c2ccc(C(=O)Nc3ccc(CC(=O)O)cc3)cc12 | Homo sapiens | CHEMBL3431933 | assay format |
| CHEMBL3431627 |  |
IC50 | = | 22.3 | nM | 507.98 | COc1ccc(Cl)cc1S(=O)(=O)N1CCc2ccc(C(=O)Nc3nc(CC(=O)O)cs3)cc21 | Homo sapiens | CHEMBL3431933 | assay format |