P49915 | GUAA_HUMAN | GMP synthase [glutamine-hydrolyzing] (GMPS)

Helixβ‑strandTurn secondary structure

Pfam Domain Table

AccessionDomainRangeColor
PF00117GATase29–209
PF00958GMP_synt_C599–692
PF02540NAD_synthase225–300

 3D structures mapped by conservation among orthologs

[ Domain: "GMP synthetase C-terminal dimerisation domain" // GMP_synt_C ]

 PyMOL session

[ Domain: "HUP domains" // tRNA_Me_trans_1st ]

 PyMOL session

[ Domain: "Class I glutamine amidotransferase-like" // GATase ]

 PyMOL session


 [ Alpha Fold Model ] (go)



 Known binders annotated in ChEMBL

 IC50 CSV
Only the first 20 rows are shown.
molecule_chembl_idstructureassay_typerelation valueunitmol_wtsmilesorganism assay_chembl_idbao_label
CHEMBL5094230 IC50 = 6.2 nM 366.81 C#CCOc1cccc(Nc2ncnc3ccc(NC(=O)CCl)cc23)c1 Homo sapiens CHEMBL5053181 single protein format
CHEMBL5093024 IC50 = 23.0 nM 342.79 COc1cccc(Nc2ncnc3ccc(NC(=O)CCl)cc23)c1 Homo sapiens CHEMBL5053181 single protein format
CHEMBL5080411 IC50 = 98.0 nM 342.78 C#CCOc1cccc(NC(=O)c2cccc(NC(=O)CCl)c2)c1 Homo sapiens CHEMBL5053181 single protein format