P49915 | GUAA_HUMAN | GMP synthase [glutamine-hydrolyzing] (GMPS)
Helixβ‑strandTurn secondary structure
Pfam Domain Table
Accession | Domain | Range | Color |
---|---|---|---|
PF00117 | GATase | 29–209 | |
PF00958 | GMP_synt_C | 599–692 | |
PF02540 | NAD_synthase | 225–300 |
3D structures mapped by conservation among orthologs
[ Domain: "GMP synthetase C-terminal dimerisation domain" // GMP_synt_C ]
[ Domain: "HUP domains" // tRNA_Me_trans_1st ]
[ Domain: "Class I glutamine amidotransferase-like" // GATase ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
---|---|---|---|---|---|---|---|---|---|---|
CHEMBL5094230 | IC50 | = | 6.2 | nM | 366.81 | C#CCOc1cccc(Nc2ncnc3ccc(NC(=O)CCl)cc23)c1 | Homo sapiens | CHEMBL5053181 | single protein format | |
CHEMBL5093024 | IC50 | = | 23.0 | nM | 342.79 | COc1cccc(Nc2ncnc3ccc(NC(=O)CCl)cc23)c1 | Homo sapiens | CHEMBL5053181 | single protein format | |
CHEMBL5080411 | IC50 | = | 98.0 | nM | 342.78 | C#CCOc1cccc(NC(=O)c2cccc(NC(=O)CCl)c2)c1 | Homo sapiens | CHEMBL5053181 | single protein format |