P49862 | KLK7_HUMAN | Kallikrein-7 (KLK7)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00089 | Trypsin - Trypsin | 30~245 |
3D structures mapped by conservation among orthologs
[ Domain: "FMN-binding split barrel 2" // Trypsin_1 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL1413622 |  |
IC50 | = | 40.0 | nM | 279.3 | Cc1ccc(C(=O)n2nc(-c3cccnc3)nc2N)cc1 | Homo sapiens | CHEMBL2412649 | single protein format |
| CHEMBL4575974 |  |
IC50 | = | 48.0 | nM | 327.34 | CCOc1cc2c(=O)oc(-c3ccccc3OC)nc2cc1OC | Homo sapiens | CHEMBL4424186 | single protein format |
| CHEMBL4228441 |  |
IC50 | = | 48.0 | nM | 580.13 | CCC[C@@H](C(=O)Nc1cccc(-c2cnn(C)c2)c1)N1C/C(=N/N(C)C)NC[C@@H](Cc2cc(Cl)ccc2OC)C1=O | Homo sapiens | CHEMBL4222616 | single protein format |
| CHEMBL4126936 |  |
IC50 | = | 58.0 | nM | 552.08 | COc1ccc(Cl)cc1C[C@@H]1CN/C(=N\N(C)C)CN([C@@H](C)C(=O)Nc2cccc(-c3cnn(C)c3)c2)C1=O | Homo sapiens | CHEMBL4125121 | single protein format |
| CHEMBL4228178 |  |
IC50 | = | 110.0 | nM | 594.16 | CCCC[C@@H](C(=O)Nc1cccc(-c2cnn(C)c2)c1)N1C/C(=N/N(C)C)NC[C@@H](Cc2cc(Cl)ccc2OC)C1=O | Homo sapiens | CHEMBL4222616 | single protein format |
| CHEMBL1464269 |  |
IC50 | = | 220.0 | nM | 299.72 | Nc1nc(-c2cccnc2)nn1C(=O)c1ccc(Cl)cc1 | Homo sapiens | CHEMBL2412649 | single protein format |
| CHEMBL1471674 |  |
IC50 | = | 230.0 | nM | 324.34 | COc1ccc(C(=O)n2nc(-c3ccccc3)nc2N)cc1OC | Homo sapiens | CHEMBL2412649 | single protein format |
| CHEMBL4554224 |  |
IC50 | = | 390.0 | nM | 432.34 | CC1=NC(c2cn(S(=O)(=O)c3ccccc3Br)c3ccc(C)cc23)CN1 | Homo sapiens | CHEMBL4372250 | single protein format |
| CHEMBL4227658 |  |
IC50 | = | 450.0 | nM | 566.11 | CC[C@@H](C(=O)Nc1cccc(-c2cnn(C)c2)c1)N1C/C(=N/N(C)C)NC[C@@H](Cc2cc(Cl)ccc2OC)C1=O | Homo sapiens | CHEMBL4222616 | single protein format |
| CHEMBL4130204 |  |
IC50 | = | 520.0 | nM | 538.05 | COc1ccc(Cl)cc1C[C@@H]1CN/C(=N\N(C)C)CN(CC(=O)Nc2cccc(-c3cnn(C)c3)c2)C1=O | Homo sapiens | CHEMBL4125121 | single protein format |
| CHEMBL4227495 |  |
IC50 | = | 590.0 | nM | 524.02 | COc1ccc(Cl)cc1C[C@@H]1CN/C(=N\N(C)C)CN(CC(=O)Nc2cccc(-c3ccco3)c2)C1=O | Homo sapiens | CHEMBL4222616 | single protein format |
| CHEMBL1580446 |  |
IC50 | = | 610.0 | nM | 218.22 | COc1ccc(C(=O)n2cnnc2N)cc1 | Homo sapiens | CHEMBL2412649 | single protein format |
| CHEMBL1580091 |  |
IC50 | = | 660.0 | nM | 329.81 | CSc1nc(-c2ccc(Cl)cc2)nn1C(=O)c1ccccc1 | Homo sapiens | CHEMBL2412649 | single protein format |
| CHEMBL4227724 |  |
IC50 | = | 670.0 | nM | 524.02 | COc1ccc(Cl)cc1C[C@@H]1CN/C(=N\N(C)C)CN(CC(=O)Nc2cccc(-c3ccoc3)c2)C1=O | Homo sapiens | CHEMBL4222616 | single protein format |
| CHEMBL4126785 |  |
IC50 | = | 790.0 | nM | 542.47 | CN(C)/N=C1/CN(CC(=O)Nc2cccc(-c3cnn(C)c3)c2)C(=O)C(Cc2c(Cl)cccc2Cl)CN1 | Homo sapiens | CHEMBL4125121 | single protein format |
| CHEMBL4216497 |  |
IC50 | = | 820.0 | nM | 536.05 | COc1ccc(Cl)cc1C[C@@H]1CN/C(=N\N(C)C)CN(CC(=O)Nc2cccc(S(C)(=O)=O)c2)C1=O | Homo sapiens | CHEMBL4181449 | single protein format |
| CHEMBL4227375 |  |
IC50 | = | 870.0 | nM | 540.09 | COc1ccc(Cl)cc1C[C@@H]1CN/C(=N\N(C)C)CN(CC(=O)Nc2cccc(-c3cccs3)c2)C1=O | Homo sapiens | CHEMBL4222616 | single protein format |
| CHEMBL4226810 |  |
IC50 | = | 920.0 | nM | 552.08 | COc1ccc(Cl)cc1C[C@@H]1CN/C(=N\N(C)C)CN([C@H](C)C(=O)Nc2cccc(-c3cnn(C)c3)c2)C1=O | Homo sapiens | CHEMBL4222616 | single protein format |
| CHEMBL4127430 |  |
IC50 | = | 940.0 | nM | 526.02 | CN(C)/N=C1/CN(CC(=O)Nc2cccc(-c3cnn(C)c3)c2)C(=O)C(Cc2c(F)cccc2Cl)CN1 | Homo sapiens | CHEMBL4125121 | single protein format |
| CHEMBL4226469 |  |
IC50 | = | 940.0 | nM | 515.01 | CNC(=O)c1cccc(NC(=O)CN2C/C(=N/N(C)C)NC[C@@H](Cc3cc(Cl)ccc3OC)C2=O)c1 | Homo sapiens | CHEMBL4222616 | single protein format |