P49840 | GSK3A_HUMAN | Glycogen synthase kinase-3 alpha (GSK3A)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 119~403 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5409061 |  |
IC50 | = | 0.07 | nM | 414.35 | N#Cc1ccc(Nc2nccc(C(=O)Nc3cnccc3OCC(F)(F)F)n2)cc1 | Homo sapiens | CHEMBL5343396 | cell-based format |
| CHEMBL5270781 |  |
IC50 | = | 0.09 | nM | 414.47 | CC1CN(c2ccncc2NC(=O)c2ccnn3cc(-c4ccccc4)nc23)CCO1 | Homo sapiens | CHEMBL5237494 | single protein format |
| CHEMBL5286391 |  |
IC50 | = | 0.09 | nM | 413.36 | O=C(Nc1cnccc1OCC(F)(F)F)c1ccnn2cc(-c3ccccc3)nc12 | Homo sapiens | CHEMBL5252013 | single protein format |
| CHEMBL5266553 |  |
IC50 | = | 0.1 | nM | 414.47 | C[C@H]1CN(c2ccncc2NC(=O)c2ccnn3cc(-c4ccccc4)nc23)CCO1 | Homo sapiens | CHEMBL5252013 | single protein format |
| CHEMBL5437994 |  |
IC50 | = | 0.15 | nM | 410.43 | O=C(Nc1cnccc1N1CCC(F)(F)CC1)c1ccnc(Nc2ccccc2)n1 | Homo sapiens | CHEMBL5343396 | cell-based format |
| CHEMBL5428013 |  |
IC50 | = | 0.15 | nM | 415.34 | N#Cc1ccc(Nc2nccc(C(=O)Nc3cncnc3OCC(F)(F)F)n2)cc1 | Homo sapiens | CHEMBL5343396 | cell-based format |
| CHEMBL5440672 |  |
IC50 | = | 0.16 | nM | 426.87 | N#Cc1ccc(Nc2nccc(C(=O)Nc3cnccc3-c3ccccc3)n2)cc1Cl | Homo sapiens | CHEMBL5343396 | cell-based format |
| CHEMBL5416472 |  |
IC50 | = | 0.16 | nM | 389.34 | O=C(Nc1cnccc1OCC(F)(F)F)c1ccnc(Nc2ccccc2)n1 | Homo sapiens | CHEMBL5343396 | cell-based format |
| CHEMBL5418606 |  |
IC50 | = | 0.17 | nM | 415.43 | COc1ccc(Nc2nccc(C(=O)Nc3cnccc3-c3ccccc3)n2)cc1F | Homo sapiens | CHEMBL5343396 | cell-based format |
| CHEMBL5268185 |  |
IC50 | = | 0.17 | nM | 444.39 | O=C(Nc1cnccc1-c1ccc(F)cc1C(F)(F)F)c1ccnc(NC(=O)C2CC2)c1 | Homo sapiens | CHEMBL5252934 | single protein format |
| CHEMBL5422776 |  |
IC50 | = | 0.18 | nM | 457.33 | O=C(Nc1cnccc1OCC(F)(F)F)c1ccnc(Nc2ccc(C(F)(F)F)cc2)n1 | Homo sapiens | CHEMBL5343396 | cell-based format |
| CHEMBL5282376 |  |
IC50 | = | 0.18 | nM | 398.42 | O=C(Nc1cnccc1N1CCC(F)(F)CC1)c1ccnn2cc(C3CC3)nc12 | Homo sapiens | CHEMBL5252013 | single protein format |
| CHEMBL5414726 |  |
IC50 | = | 0.19 | nM | 385.4 | O=C(Nc1cnccc1-c1ccc(F)cc1)c1ccnc(Nc2ccccc2)n1 | Homo sapiens | CHEMBL5343396 | cell-based format |
| CHEMBL5407971 |  |
IC50 | = | 0.19 | nM | 445.5 | CS(=O)(=O)c1ccc(Nc2nccc(C(=O)Nc3cnccc3-c3ccccc3)n2)cc1 | Homo sapiens | CHEMBL5343396 | cell-based format |
| CHEMBL5282319 |  |
IC50 | = | 0.21 | nM | 400.44 | O=C(Nc1cnccc1N1CCOCC1)c1ccnn2cc(-c3ccccc3)nc12 | Homo sapiens | CHEMBL5252013 | single protein format |
| CHEMBL5270555 |  |
IC50 | = | 0.22 | nM | 434.45 | O=C(Nc1cnccc1N1CCC(F)(F)CC1)c1ccnn2cc(-c3ccccc3)nc12 | Homo sapiens | CHEMBL5252013 | single protein format |
| CHEMBL5436595 |  |
IC50 | = | 0.22 | nM | 381.44 | Cc1ccc(Nc2nccc(C(=O)Nc3cnccc3-c3ccccc3)n2)cc1 | Homo sapiens | CHEMBL5343396 | cell-based format |
| CHEMBL5283650 |  |
IC50 | = | 0.23 | nM | 468.44 | O=C(Nc1cnccc1N1CCOCC1)c1ccnn2cc(-c3ccc(C(F)(F)F)cc3)nc12 | Homo sapiens | CHEMBL5252013 | single protein format |
| CHEMBL5282654 |  |
IC50 | = | 0.24 | nM | 398.47 | O=C(Nc1cnccc1N1CCCCC1)c1ccnn2cc(-c3ccccc3)nc12 | Homo sapiens | CHEMBL5252013 | single protein format |
| CHEMBL5419652 |  |
IC50 | = | 0.25 | nM | 410.41 | N#Cc1ccc(Nc2nccc(C(=O)Nc3cnccc3-c3ccc(F)cc3)n2)cc1 | Homo sapiens | CHEMBL5343396 | cell-based format |