P49810 | PSN2_HUMAN | Presenilin-2 (PSEN2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF01080 | Presenilin - Presenilin | 82~306 | |
| PF01080 | Presenilin - Presenilin | 351~438 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL2159511 |  |
IC50 | = | 1.0 | nM | 506.98 | CS(=O)(=O)CC[C@@H]1OCC[C@@]2(S(=O)(=O)c3ccc(Cl)cc3)c3c(F)ccc(F)c3OC[C@@H]12 | Homo sapiens | CHEMBL2163022 | cell-based format |
| CHEMBL2159510 |  |
IC50 | = | 2.0 | nM | 521.0 | CCS(=O)(=O)CC[C@@H]1OCC[C@@]2(S(=O)(=O)c3ccc(Cl)cc3)c3c(F)ccc(F)c3OC[C@@H]12 | Homo sapiens | CHEMBL2163022 | cell-based format |
| CHEMBL2159509 |  |
IC50 | = | 3.0 | nM | 535.03 | CC(C)S(=O)(=O)CC[C@@H]1OCC[C@@]2(S(=O)(=O)c3ccc(Cl)cc3)c3c(F)ccc(F)c3OC[C@@H]12 | Homo sapiens | CHEMBL2163022 | cell-based format |
| CHEMBL2159689 |  |
IC50 | = | 6.0 | nM | 501.94 | CNC(=O)OCC[C@@H]1OCC[C@@]2(S(=O)(=O)c3ccc(Cl)cc3)c3c(F)ccc(F)c3OC[C@@H]12 | Homo sapiens | CHEMBL2163022 | cell-based format |
| CHEMBL2159687 |  |
IC50 | = | 8.0 | nM | 444.88 | O=S(=O)(c1ccc(Cl)cc1)[C@@]12CCO[C@@H](CCO)[C@@H]1COc1c(F)ccc(F)c12 | Homo sapiens | CHEMBL2163022 | cell-based format |
| CHEMBL2159691 |  |
IC50 | = | 16.0 | nM | 453.89 | N#CCC[C@@H]1OCC[C@@]2(S(=O)(=O)c3ccc(Cl)cc3)c3c(F)ccc(F)c3OC[C@@H]12 | Homo sapiens | CHEMBL2163022 | cell-based format |
| CHEMBL2159690 |  |
IC50 | = | 20.0 | nM | 515.96 | CCNC(=O)OCC[C@@H]1OCC[C@@]2(S(=O)(=O)c3ccc(Cl)cc3)c3c(F)ccc(F)c3OC[C@@H]12 | Homo sapiens | CHEMBL2163022 | cell-based format |