P49761 | CLK3_HUMAN | Dual specificity protein kinase CLK3 (CLK3)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 156~472 |
3D structures mapped by conservation among orthologs
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4284209 |  |
IC50 | = | 2.9 | nM | 456.6 | CC(C)c1cnn2c(NCc3ccc(-c4ccccn4)cc3)nc(N[C@H]3CC[C@H](N)CC3)nc12 | Homo sapiens | CHEMBL5237373 | single protein format |
| CHEMBL4797564 |  |
IC50 | = | 6.5 | nM | 382.43 | CNc1nc(NCc2ncccn2)c2c(-c3ccc4ncccc4c3)c[nH]c2n1 | Homo sapiens | CHEMBL5237393 | single protein format |
| CHEMBL4083249 |  |
IC50 | = | 8.0 | nM | 409.42 | C[C@@H](c1ccc(F)cc1)n1nnc2cnc3ccc(-c4ccc5ocnc5c4)cc3c21 | Homo sapiens | CHEMBL5237373 | single protein format |
| CHEMBL5441121 |  |
IC50 | = | 10.0 | nM | 436.37 | Cl.Cl.NC[C@@H](NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1)c1ccccc1 | Homo sapiens | CHEMBL5363956 | cell-based format |
| CHEMBL393525 |  |
IC50 | = | 11.9 | nM | 452.29 | Cc1ccc([N+](=O)[O-])cc1S(=O)(=O)N(C)/N=C/c1cnc2ccc(Br)cn12 | Homo sapiens | CHEMBL5251367 | cell-based format |
| CHEMBL4784318 |  |
IC50 | = | 22.0 | nM | 427.51 | CN1CCN(c2cc(C(=O)Nc3cc4cc(-c5cnn(C)c5)ccc4cn3)ccn2)CC1 | Homo sapiens | CHEMBL5105880 | single protein format |
| CHEMBL5438728 |  |
IC50 | = | 23.0 | nM | 436.37 | Cl.Cl.NCC(NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1)c1ccccc1 | Homo sapiens | CHEMBL5363956 | cell-based format |
| CHEMBL4796016 |  |
IC50 | = | 28.0 | nM | 282.73 | O=C1NCc2ccc3c(-c4cccc(Cl)c4)c[nH]c3c21 | Homo sapiens | CHEMBL5237373 | single protein format |
| CHEMBL261720 |  |
IC50 | = | 29.2 | nM | 425.45 | Nc1nc(Nc2ccc(S(N)(=O)=O)cc2)nn1C(=S)Nc1c(F)cccc1F | Homo sapiens | CHEMBL4003367 | assay format |
| CHEMBL5439276 |  |
IC50 | = | 30.0 | nM | 450.4 | CNCC(NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1)c1ccccc1.Cl.Cl | Homo sapiens | CHEMBL5363956 | cell-based format |
| CHEMBL5430262 |  |
IC50 | = | 38.0 | nM | 364.43 | O=C1NC(NC[C@H](O)c2ccccc2)=N/C1=C\c1ccc2ncsc2c1 | Homo sapiens | CHEMBL5363956 | cell-based format |
| CHEMBL1230165 |  |
IC50 | = | 41.0 | nM | 349.78 | O=C(O)c1ccc2c(c1)nc(Nc1cccc(Cl)c1)c1ccncc12 | Homo sapiens | CHEMBL1663331 | single protein format |
| CHEMBL5408907 |  |
IC50 | = | 49.0 | nM | 342.42 | CO[C@@H]1CCC[C@H]1NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 | Homo sapiens | CHEMBL5363956 | cell-based format |
| CHEMBL5427842 |  |
IC50 | = | 53.0 | nM | 342.42 | CO[C@H]1CCC[C@@H]1NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 | Homo sapiens | CHEMBL5363956 | cell-based format |
| CHEMBL5436754 |  |
IC50 | = | 73.0 | nM | 356.45 | CO[C@H]1CCC[C@H](NC2=N/C(=C\c3ccc4ncsc4c3)C(=O)N2)C1 | Homo sapiens | CHEMBL5363956 | cell-based format |
| CHEMBL4297639 |  |
IC50 | = | 76.1 | nM | 505.56 | CC(C)CC(=O)Nc1cncc(-c2ccc3[nH]nc(-c4nc5cncc(-c6cccc(F)c6)c5[nH]4)c3c2)c1 | Homo sapiens | CHEMBL5251367 | cell-based format |
| CHEMBL3774448 |  |
IC50 | = | 86.6 | nM | 272.35 | O=C1NC(=S)S/C1=C\c1ccc2ncccc2c1 | Homo sapiens | CHEMBL3778447 | assay format |
| CHEMBL5422486 |  |
IC50 | = | 90.0 | nM | 432.47 | O=C1NC(NC23CC4(F)CC(F)(CC(F)(C4)C2)C3)=N/C1=C\c1ccc2ncsc2c1 | Homo sapiens | CHEMBL5363956 | cell-based format |
| CHEMBL5081787 |  |
IC50 | = | 92.6 | nM | 401.28 | O=C1N=C(Nc2c(Cl)cccc2Cl)S/C1=C\c1ccc2nccnc2c1 | Homo sapiens | CHEMBL5251367 | cell-based format |
| CHEMBL5396550 |  |
IC50 | = | 96.0 | nM | 376.43 | O=C1NC(NC2CCCCC(F)(F)C2)=N/C1=C\c1ccc2ncsc2c1 | Homo sapiens | CHEMBL5363956 | cell-based format |