P49760 | CLK2_HUMAN | Dual specificity protein kinase CLK2 (CLK2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 163~479 |
3D structures mapped by conservation among orthologs
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5438158 |  |
IC50 | = | 0.0 | nM | 396.49 | O=C1NC(NC23CC4CC(CC(F)(C4)C2)C3)=N/C1=C\c1ccc2ncsc2c1 | Homo sapiens | CHEMBL5363955 | single protein format |
| CHEMBL5417147 |  |
IC50 | = | 0.0 | nM | 408.53 | COC12CC3CC(CC(NC4=N/C(=C\c5ccc6ncsc6c5)C(=O)N4)(C3)C1)C2 | Homo sapiens | CHEMBL5363955 | single protein format |
| CHEMBL5405059 |  |
IC50 | = | 0.0 | nM | 394.5 | O=C1NC(NC23CC4CC(CC(O)(C4)C2)C3)=N/C1=C\c1ccc2ncsc2c1 | Homo sapiens | CHEMBL5363955 | single protein format |
| CHEMBL5422486 |  |
IC50 | = | 0.0 | nM | 432.47 | O=C1NC(NC23CC4(F)CC(F)(CC(F)(C4)C2)C3)=N/C1=C\c1ccc2ncsc2c1 | Homo sapiens | CHEMBL5363955 | single protein format |
| CHEMBL4797564 |  |
IC50 | = | 0.096 | nM | 382.43 | CNc1nc(NCc2ncccn2)c2c(-c3ccc4ncccc4c3)c[nH]c2n1 | Homo sapiens | CHEMBL5237391 | single protein format |
| CHEMBL4546504 |  |
IC50 | = | 0.261 | nM | 555.99 | C[C@@H](Oc1cc(C(=O)N(C)C)ccc1Nc1nc(O[C@H]2CC[C@@](C)(O)CC2)c2c(Cl)c[nH]c2n1)C(F)(F)F | Homo sapiens | CHEMBL4349111 | assay format |
| CHEMBL5091238 |  |
IC50 | = | 0.6 | nM | 378.5 | O=C1NC(NC23CC4CC(CC(C4)C2)C3)=N/C1=C\c1ccc2ncsc2c1 | Homo sapiens | CHEMBL5251366 | cell-based format |
| CHEMBL4800084 |  |
IC50 | = | 0.822 | nM | 442.52 | COc1ccc(NC(=O)c2n[nH]c3ccc(-c4cncc(CN5CCCCC5)c4)cc23)cn1 | Homo sapiens | CHEMBL5105878 | single protein format |
| CHEMBL5269810 |  |
IC50 | = | 0.822 | nM | 441.54 | COc1ccc(NC(=O)c2n[nH]c3ccc(-c4cncc(CN5CCCCC5)c4)cc23)cc1 | Homo sapiens | CHEMBL5237382 | single protein format |
| CHEMBL5409574 |  |
IC50 | = | 1.0 | nM | 471.61 | CS(=O)(=O)NC12CC3CC(CC(NC4=N/C(=C\c5ccc6ncsc6c5)C(=O)N4)(C3)C1)C2 | Homo sapiens | CHEMBL5363955 | single protein format |
| CHEMBL5400230 |  |
IC50 | = | 1.0 | nM | 364.47 | O=C1NC(NC23CC4CC(CC2C4)C3)=N/C1=C\c1ccc2ncsc2c1 | Homo sapiens | CHEMBL5363955 | single protein format |
| CHEMBL4848224 |  |
IC50 | = | 1.06 | nM | 395.82 | O=C(OCCF)c1ccc2c(c1)nc(Nc1cccc(Cl)c1)c1ccncc12 | Homo sapiens | CHEMBL4808935 | single protein format |
| CHEMBL393525 |  |
IC50 | = | 1.1 | nM | 452.29 | Cc1ccc([N+](=O)[O-])cc1S(=O)(=O)N(C)/N=C/c1cnc2ccc(Br)cn12 | Homo sapiens | CHEMBL5251366 | cell-based format |
| CHEMBL5202010 |  |
IC50 | = | 1.4 | nM | 408.4 | COc1ncnn2ccc(-c3cnc4nc(C)n(Cc5nnc([C@@H](C)F)o5)c4c3)c12 | Homo sapiens | CHEMBL5105878 | single protein format |
| CHEMBL4872225 |  |
IC50 | = | 1.54 | nM | 413.81 | O=C(OCC(F)F)c1ccc2c(c1)nc(Nc1cccc(Cl)c1)c1ccncc12 | Homo sapiens | CHEMBL4808935 | single protein format |
| CHEMBL4848072 |  |
IC50 | = | 1.69 | nM | 503.73 | O=C(OCCI)c1ccc2c(c1)nc(Nc1cccc(Cl)c1)c1ccncc12 | Homo sapiens | CHEMBL4808935 | single protein format |
| CHEMBL5429404 |  |
IC50 | = | 2.0 | nM | 376.44 | O=C1NC(N[C@H]2c3ccccc3C[C@@H]2O)=N/C1=C\c1ccc2ncsc2c1 | Homo sapiens | CHEMBL5363955 | single protein format |
| CHEMBL5418722 |  |
IC50 | = | 2.0 | nM | 461.59 | O=C1NC(NC23CC4CC(CC(NC(=O)C5CC5)(C4)C2)C3)=N/C1=C\c1ccc2ncsc2c1 | Homo sapiens | CHEMBL5363955 | single protein format |
| CHEMBL4784318 |  |
IC50 | = | 2.0 | nM | 427.51 | CN1CCN(c2cc(C(=O)Nc3cc4cc(-c5cnn(C)c5)ccc4cn3)ccn2)CC1 | Homo sapiens | CHEMBL5105879 | single protein format |
| CHEMBL5438293 |  |
IC50 | = | 2.0 | nM | 362.43 | O=C1NC(NC23CC4CC(CC(C4)C2)C3)=N/C1=C\c1ccc2ncoc2c1 | Homo sapiens | CHEMBL5363955 | single protein format |