P49759 | CLK1_HUMAN | Dual specificity protein kinase CLK1 (CLK1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 161~477 |
3D structures mapped by conservation among orthologs
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4531334 |  |
IC50 | = | 0.67 | nM | 482.59 | CN1CCN(C(=O)C(C)(C)c2ccc(C(=O)Nc3cn4cc(-c5ccncc5)ccc4n3)cc2)CC1 | Homo sapiens | CHEMBL4883197 | single protein format |
| CHEMBL5428750 |  |
IC50 | = | 1.0 | nM | 345.4 | COC[C@@H](CC(C)C)NC1=N/C(=C\c2ccc3c(c2)OCO3)C(=O)N1 | Homo sapiens | CHEMBL5378444 | single protein format |
| CHEMBL5200367 |  |
IC50 | = | 1.1 | nM | 360.42 | CC(C)(C)c1ccc(C(=O)Nc2cn3cc(-c4cn[nH]c4)ccc3n2)cn1 | Homo sapiens | CHEMBL5116220 | assay format |
| CHEMBL5286791 |  |
IC50 | = | 1.1 | nM | 376.42 | CC(C)(CO)c1ccc(C(=O)Nc2cn3cc(-c4cn[nH]c4)ccc3n2)cn1 | Homo sapiens | CHEMBL5237375 | single protein format |
| CHEMBL5283453 |  |
IC50 | = | 1.1 | nM | 371.44 | CC(C)(C)c1ccc(C(=O)Nc2cn3cc(-c4ccncc4)ccc3n2)cn1 | Homo sapiens | CHEMBL5237375 | single protein format |
| CHEMBL5424488 |  |
IC50 | = | 1.4 | nM | 334.35 | COc1ccc2sc(C(=O)NNc3cc(F)cc(F)c3)cc2c1 | Homo sapiens | CHEMBL5347405 | single protein format |
| CHEMBL5424844 |  |
IC50 | = | 1.7 | nM | 367.26 | COc1ccc2sc(C(=O)NNc3cc(Cl)cc(Cl)c3)cc2c1 | Homo sapiens | CHEMBL5347405 | single protein format |
| CHEMBL2392364 |  |
IC50 | = | 2.0 | nM | 374.23 | Clc1cc(Cl)cc(CNc2nccc(-c3ccc4c(c3)OCO4)n2)c1 | Homo sapiens | CHEMBL2394344 | single protein format |
| CHEMBL4083249 |  |
IC50 | = | 2.0 | nM | 409.42 | C[C@@H](c1ccc(F)cc1)n1nnc2cnc3ccc(-c4ccc5ocnc5c4)cc3c21 | Homo sapiens | CHEMBL4014111 | cell-based format |
| CHEMBL5411169 |  |
IC50 | = | 3.7 | nM | 328.39 | COc1cccc(NNC(=O)c2cc3cc(OC)ccc3s2)c1 | Homo sapiens | CHEMBL5347405 | single protein format |
| CHEMBL5408531 |  |
IC50 | = | 4.0 | nM | 375.48 | Cn1cc2cc(/C=C3\N=C(NC45CC6CC(CC(C6)C4)C5)NC3=O)ccc2n1 | Homo sapiens | CHEMBL5363954 | cell-based format |
| CHEMBL5428651 |  |
IC50 | = | 4.0 | nM | 394.5 | O=C1NC(N[C@H]2C3CC4CC2C[C@](O)(C4)C3)=N/C1=C\c1ccc2ncsc2c1 | Homo sapiens | CHEMBL5363954 | cell-based format |
| CHEMBL5205505 |  |
IC50 | = | 4.0 | nM | 359.38 | COc1ccc2sc(C(=O)NC(=O)c3ccc(F)cc3OC)cc2c1 | Homo sapiens | CHEMBL5116191 | assay format |
| CHEMBL4853178 |  |
IC50 | = | 4.0 | nM | 408.46 | COc1ccc(CNC(=O)c2cnc3ccc(-c4ccc5ncccc5c4)cn23)cc1 | Homo sapiens | CHEMBL4815931 | single protein format |
| CHEMBL4797564 |  |
IC50 | = | 4.8 | nM | 382.43 | CNc1nc(NCc2ncccn2)c2c(-c3ccc4ncccc4c3)c[nH]c2n1 | Homo sapiens | CHEMBL5237392 | single protein format |
| CHEMBL5439392 |  |
IC50 | = | 5.0 | nM | 378.46 | COC[C@H](NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1)c1ccccc1 | Homo sapiens | CHEMBL5363954 | cell-based format |
| CHEMBL5417631 |  |
IC50 | = | 5.0 | nM | 408.85 | COc1cncc(-c2c[nH]c3ncc(NC(=O)c4ccc(Cl)cc4OC)cc23)c1 | Homo sapiens | CHEMBL5387884 | single protein format |
| CHEMBL5405572 |  |
IC50 | = | 5.0 | nM | 361.45 | O=C1NC(NC23CC4CC(CC(C4)C2)C3)=N/C1=C\c1ccc2[nH]ncc2c1 | Homo sapiens | CHEMBL5363954 | cell-based format |
| CHEMBL5404416 |  |
IC50 | = | 5.0 | nM | 361.45 | O=C1NC(NC23CC4CC(CC(C4)C2)C3)=N/C1=C\c1ccc2[nH]cnc2c1 | Homo sapiens | CHEMBL5363954 | cell-based format |
| CHEMBL4861035 |  |
IC50 | = | 5.0 | nM | 409.45 | COc1ccc(NNC(=O)c2cnc3ccc(-c4ccc5ncccc5c4)cn23)cc1 | Homo sapiens | CHEMBL4815931 | single protein format |