P49682 | CXCR3_HUMAN | C-X-C chemokine receptor type 3 (CXCR3)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00001 | 7tm_1 - 7 transmembrane receptor (rhodopsin family) | 70~318 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3944008 |  |
IC50 | = | 0.1 | nM | 489.53 | Cc1ccnn1CC(=O)N1CCN(c2sc(C(F)(F)F)nc2-c2nc3ccccc3[nH]2)C[C@H]1C | Homo sapiens | CHEMBL3888033 | cell-based format |
| CHEMBL3905581 |  |
IC50 | = | 0.1 | nM | 547.61 | Cc1nc(C)n(CC(=O)N2CCN(c3sc(C(F)(F)F)nc3-c3nc4cc(CCN)ccc4[nH]3)C[C@H]2C)n1 | Homo sapiens | CHEMBL3888033 | cell-based format |
| CHEMBL3924716 |  |
IC50 | = | 0.1 | nM | 509.95 | C[C@@H]1CN(c2sc(C(F)(F)F)nc2-c2nc3ccccc3[nH]2)CCN1C(=O)Cn1cc(Cl)cn1 | Homo sapiens | CHEMBL3888033 | cell-based format |
| CHEMBL3949279 |  |
IC50 | = | 0.2 | nM | 457.56 | C[C@@H]1CN(c2scnc2-c2nc3ccccc3[nH]2)CCN1C(=O)Cn1ccc2ccncc21 | Homo sapiens | CHEMBL3888033 | cell-based format |
| CHEMBL3912920 |  |
IC50 | = | 0.2 | nM | 489.53 | Cc1ccn(CC(=O)N2CCN(c3sc(C(F)(F)F)nc3-c3nc4ccccc4[nH]3)C[C@H]2C)n1 | Homo sapiens | CHEMBL3888033 | cell-based format |
| CHEMBL1681882 |  |
IC50 | = | 0.2 | nM | 522.5 | CCNC(=O)c1cnc(N2CCN(C3CCN(Cc4ccc(Cl)cc4F)CC3)[C@@H](CC)C2)c(Cl)c1 | Homo sapiens | CHEMBL3119548 | single protein format |
| CHEMBL3898933 |  |
IC50 | = | 0.2 | nM | 492.01 | C[C@@H]1CN(c2scnc2-c2nc3ccc(Cl)cc3[nH]2)CCN1C(=O)Cn1ccc2cccnc21 | Homo sapiens | CHEMBL3888033 | cell-based format |
| CHEMBL3899279 |  |
IC50 | = | 0.3 | nM | 527.54 | C[C@@H]1CN(c2sc(C(F)(F)F)nc2-c2nc3cccnc3[nH]2)CCN1C(=O)Cn1cnc2cccnc21 | Homo sapiens | CHEMBL3888033 | cell-based format |
| CHEMBL472288 |  |
IC50 | = | 0.3 | nM | 504.51 | CCNC(=O)c1cnc(N2CCN(C3CCN(Cc4ccc(Cl)cc4)CC3)[C@@H](CC)C2)c(Cl)c1 | Homo sapiens | CHEMBL1924404 | cell-based format |
| CHEMBL1921863 |  |
IC50 | = | 0.3 | nM | 506.48 | CC[C@H]1CN(c2nc(N)c(C(=O)NC)nc2Cl)CCN1C1CCN(Cc2ccc(Cl)cc2)CC1 | Homo sapiens | CHEMBL1924404 | cell-based format |
| CHEMBL1921866 |  |
IC50 | = | 0.3 | nM | 550.54 | CC[C@H]1CN(c2nc(N)c(C(=O)NCC(C)O)nc2Cl)CCN1C1CCN(Cc2ccc(Cl)cc2)CC1 | Homo sapiens | CHEMBL1924404 | cell-based format |
| CHEMBL3909429 |  |
IC50 | = | 0.3 | nM | 508.55 | C[C@@H]1CN(c2scnc2-c2nc3ccccc3[nH]2)CCN1C(=O)CN1C(=O)C(F)(F)c2ccccc21 | Homo sapiens | CHEMBL3888033 | cell-based format |
| CHEMBL3116468 |  |
IC50 | = | 0.3 | nM | 517.48 | CC[C@H]1CN(c2ncc(-c3ncc[nH]3)cc2Cl)CCN1C1CCN(Cc2ccc(Cl)cc2F)CC1 | Homo sapiens | CHEMBL3119548 | single protein format |
| CHEMBL3116476 |  |
IC50 | = | 0.4 | nM | 531.49 | CC[C@H]1CN(c2nc(N)c(-c3nnc(C)o3)nc2Cl)CCN1C1CCN(Cc2ccc(Cl)cc2)CC1 | Homo sapiens | CHEMBL3119548 | single protein format |
| CHEMBL3894522 |  |
IC50 | = | 0.4 | nM | 494.53 | C[C@@H]1CN(c2scnc2-c2nc3cc(F)c(F)cc3[nH]2)CCN1C(=O)Cn1cnc2cccnc21 | Homo sapiens | CHEMBL3888033 | cell-based format |
| CHEMBL1921865 |  |
IC50 | = | 0.4 | nM | 536.51 | CC[C@H]1CN(c2nc(N)c(C(=O)NCCO)nc2Cl)CCN1C1CCN(Cc2ccc(Cl)cc2)CC1 | Homo sapiens | CHEMBL1924404 | cell-based format |
| CHEMBL3970456 |  |
IC50 | = | 0.4 | nM | 500.55 | Cc1ccc(CC(=O)N2CCN(c3sc(C(F)(F)F)nc3-c3nc4ccccc4[nH]3)C[C@H]2C)cn1 | Homo sapiens | CHEMBL3888033 | cell-based format |
| CHEMBL3986477 |  |
IC50 | = | 0.5 | nM | 476.54 | C[C@@H]1CN(c2scnc2-c2nc3cc(F)ccc3[nH]2)CCN1C(=O)Cn1cnc2cccnc21 | Homo sapiens | CHEMBL3888033 | cell-based format |
| CHEMBL3982804 |  |
IC50 | = | 0.5 | nM | 475.5 | C[C@@H]1CN(c2sc(C(F)(F)F)nc2-c2nc3ccccc3[nH]2)CCN1C(=O)Cn1cccn1 | Homo sapiens | CHEMBL3888033 | cell-based format |
| CHEMBL3971111 |  |
IC50 | = | 0.5 | nM | 507.02 | Cc1c(Cl)ccc2[nH]c(-c3ncsc3N3CCN(C(=O)Cn4cnc5cccnc54)[C@H](C)C3)nc12 | Homo sapiens | CHEMBL3888033 | cell-based format |