P49674 | KC1E_HUMAN | Casein kinase I isoform epsilon (CSNK1E)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 9~228 |
3D structures mapped by conservation among orthologs
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3962177 |  |
IC50 | = | 0.2 | nM | 572.58 | Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccnc(F)c4)cn3n2)c1N1CCN(C(=O)CN)CC1 | Homo sapiens | CHEMBL3889261 | single protein format |
| CHEMBL3981677 |  |
IC50 | = | 0.8 | nM | 577.62 | Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccncc4)cn3n2)c1C1CCN(Cc2ccon2)CC1 | Homo sapiens | CHEMBL3889261 | single protein format |
| CHEMBL3921967 |  |
IC50 | = | 1.0 | nM | 448.93 | CC1(O)CCC(NC(=O)N2CCn3c(Cl)c(-c4cccc(F)c4)c(C(N)=O)c3C2)CC1 | Homo sapiens | CHEMBL3887985 | single protein format |
| CHEMBL3902265 |  |
IC50 | = | 1.0 | nM | 595.61 | Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccnc(F)c4)cn3n2)c1C1CCN(Cc2ccon2)CC1 | Homo sapiens | CHEMBL3889261 | single protein format |
| CHEMBL3944279 |  |
IC50 | < | 1.0 | nM | 370.45 | COc1ccc(-c2cn3c(c2C(N)=O)CN(C(=O)NC(C)(C)C)CC3)cc1 | Homo sapiens | CHEMBL3887985 | single protein format |
| CHEMBL3958519 |  |
IC50 | < | 1.0 | nM | 461.93 | CON=C1CCC(NC(=O)N2CCn3c(Cl)c(-c4cccc(F)c4)c(C(N)=O)c3C2)CC1 | Homo sapiens | CHEMBL3887985 | single protein format |
| CHEMBL3933557 |  |
IC50 | < | 1.0 | nM | 349.39 | CC(C)(C)ON=C1CCC(NC(=O)Oc2ccc([N+](=O)[O-])cc2)CC1 | Homo sapiens | CHEMBL3887985 | single protein format |
| CHEMBL3948935 |  |
IC50 | < | 1.0 | nM | 383.43 | CC(C)(C)NC(=O)N1CCn2c(C#N)c(-c3cccc(F)c3)c(C(N)=O)c2C1 | Homo sapiens | CHEMBL3887985 | single protein format |
| CHEMBL3967436 |  |
IC50 | < | 1.0 | nM | 437.4 | CC(C)(NC(=O)N1CCn2c(C#N)c(-c3cccc(F)c3)c(C(N)=O)c2C1)C(F)(F)F | Homo sapiens | CHEMBL3887985 | single protein format |
| CHEMBL3921116 |  |
IC50 | < | 1.0 | nM | 437.31 | CC(C)(C)NC(=O)N1CCn2c(Br)c(-c3cccc(F)c3)c(C(N)=O)c2C1 | Homo sapiens | CHEMBL3887985 | single protein format |
| CHEMBL4483506 |  |
IC50 | = | 1.0 | nM | 442.54 | Fc1ccc(-c2nc3ccc(N4CCC(N5CCCC5)CC4)nn3c2-c2ccncc2)cc1 | Homo sapiens | CHEMBL4328713 | single protein format |
| CHEMBL3902838 |  |
IC50 | = | 1.0 | nM | 581.66 | Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccnc(N5CCOCC5)c4)cn3n2)c1C1CCNCC1 | Homo sapiens | CHEMBL3889261 | single protein format |
| CHEMBL3981764 |  |
IC50 | < | 1.0 | nM | 445.45 | N#Cc1c(-c2cccc(F)c2)c(C(N)=O)c2n1CCN(C(=O)NC1CCC(F)(F)CC1)C2 | Homo sapiens | CHEMBL3887985 | single protein format |
| CHEMBL3922511 |  |
IC50 | = | 1.3 | nM | 571.59 | Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccnc(F)c4)cn3n2)c1C1CCN(CC(N)=O)CC1 | Homo sapiens | CHEMBL3889261 | single protein format |
| CHEMBL3939027 |  |
IC50 | = | 1.3 | nM | 572.58 | Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccnc(F)c4)cn3n2)c1N1CCN(CC(N)=O)CC1 | Homo sapiens | CHEMBL3889261 | single protein format |
| CHEMBL3895083 |  |
IC50 | = | 1.5 | nM | 540.6 | Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccncc4)cn3n2)c1C1CCN(CCO)CC1 | Homo sapiens | CHEMBL3889261 | single protein format |
| CHEMBL3982382 |  |
IC50 | = | 1.5 | nM | 426.59 | CSc1ccc(-c2c(C(N)=O)c3n(c2C2CC2)CCN(C(=O)NC(C)(C)C)C3)cc1 | Homo sapiens | CHEMBL3887985 | single protein format |
| CHEMBL3957543 |  |
IC50 | = | 1.5 | nM | 593.69 | Cc1nc(-c2ccncc2)sc1C(=O)Nc1cn2nc(-c3c(-c4ccc(F)cc4)nn(C)c3C3CCNCC3)ccc2n1 | Homo sapiens | CHEMBL3889261 | single protein format |
| CHEMBL3907925 |  |
IC50 | = | 1.8 | nM | 582.64 | Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccnc(N5CCOCC5)c4)cn3n2)c1N1CCNCC1 | Homo sapiens | CHEMBL3889261 | single protein format |
| CHEMBL3893731 |  |
IC50 | = | 1.8 | nM | 593.69 | Cc1nc(-c2cccnc2)sc1C(=O)Nc1cn2nc(-c3c(-c4ccc(F)cc4)nn(C)c3C3CCNCC3)ccc2n1 | Homo sapiens | CHEMBL3889261 | single protein format |