P49336 | CDK8_HUMAN | Cyclin-dependent kinase 8 (CDK8)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 26~335 |
3D structures mapped by conservation among orthologs
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3827983 |  |
IC50 | = | 0.2 | nM | 343.39 | CNC(=O)c1ccc2cncc(-c3ccc(-c4cnn(C)c4)cc3)c2n1 | Homo sapiens | CHEMBL3829689 | cell-based format |
| CHEMBL3828116 |  |
IC50 | = | 0.5 | nM | 329.36 | Cn1cc(-c2ccc(-c3cncc4ccc(C(N)=O)nc34)cc2)cn1 | Homo sapiens | CHEMBL3829689 | cell-based format |
| CHEMBL3956719 |  |
IC50 | = | 0.6 | nM | 339.83 | Cc1n[nH]c2ccc(C(=O)N3CCC[C@H]3c3ccc(Cl)cc3)cc12 | Homo sapiens | CHEMBL3854802 | cell-based format |
| CHEMBL3828003 |  |
IC50 | = | 0.6 | nM | 342.4 | CNC(=O)c1ccc2cncc(-c3ccc(-c4cnn(C)c4)cc3)c2c1 | Homo sapiens | CHEMBL3829689 | cell-based format |
| CHEMBL3827327 |  |
IC50 | = | 1.1 | nM | 368.44 | Cn1cc(-c2ccc(-c3cncc4ccc(C(=O)NC5CC5)cc34)cc2)cn1 | Homo sapiens | CHEMBL3829689 | cell-based format |
| CHEMBL4455382 |  |
IC50 | = | 1.4 | nM | 356.43 | CN(C)C(=O)Cn1cc(-c2ccc(-c3cncc4ccccc34)cc2)cn1 | Homo sapiens | CHEMBL5146263 | single protein format |
| CHEMBL4791276 |  |
IC50 | = | 1.5 | nM | 271.32 | CCn1c(C(N)=O)cc2c1-c1ccncc1OC2(C)C | Homo sapiens | CHEMBL4742449 | cell-based format |
| CHEMBL3798944 |  |
IC50 | = | 1.6 | nM | 480.01 | CC(C)(O)Cn1cc(-c2ccc(-c3cncc(Cl)c3N3CCC4(CCNC4=O)CC3)cc2)cn1 | Homo sapiens | CHEMBL3803436 | single protein format |
| CHEMBL3797855 |  |
IC50 | = | 1.7 | nM | 396.88 | Nc1n[nH]c2cc(-c3cncc(Cl)c3N3CCC4(CCNC4=O)CC3)ccc12 | Homo sapiens | CHEMBL3803436 | single protein format |
| CHEMBL3828637 |  |
IC50 | = | 1.7 | nM | 368.42 | CNC(=O)c1ccc2cncc(-c3ccc4c(c3)CS(=O)(=O)N4C)c2n1 | Homo sapiens | CHEMBL3829689 | cell-based format |
| CHEMBL3798853 |  |
IC50 | = | 1.9 | nM | 463.95 | CN1c2ccc(-c3cnc(N)c(Cl)c3N3CCC4(CC3)CNC(=O)O4)cc2CS1(=O)=O | Homo sapiens | CHEMBL3803436 | single protein format |
| CHEMBL3966985 |  |
IC50 | = | 2.0 | nM | 325.8 | Cc1n[nH]c2ccc(C(=O)N3CC[C@H]3c3ccc(Cl)cc3)cc12 | Homo sapiens | CHEMBL3854802 | cell-based format |
| CHEMBL4877883 |  |
IC50 | = | 2.0 | nM | 435.92 | Cn1ncc2cc(-c3cnc4[nH]nc(Cl)c4c3N3CCC4(CCNC4=O)CC3)ccc21 | Homo sapiens | CHEMBL4828665 | cell-based format |
| CHEMBL3827799 |  |
IC50 | = | 2.0 | nM | 369.43 | Cn1cc(-c2ccc(-c3cncc4ccc(C(=O)N5CCC5)nc34)cc2)cn1 | Homo sapiens | CHEMBL3829689 | cell-based format |
| CHEMBL3799581 |  |
IC50 | = | 2.1 | nM | 411.9 | Nc1ncc(-c2ccc3c(N)n[nH]c3c2)c(N2CCC3(CCNC3=O)CC2)c1Cl | Homo sapiens | CHEMBL3803436 | single protein format |
| CHEMBL3799212 |  |
IC50 | = | 2.3 | nM | 461.98 | CN1c2ccc(-c3cnc(N)c(Cl)c3N3CCC4(CCNC4=O)CC3)cc2CS1(=O)=O | Homo sapiens | CHEMBL3803436 | single protein format |
| CHEMBL3798382 |  |
IC50 | = | 2.3 | nM | 410.91 | Cn1ncc2cc(-c3cnc(N)c(Cl)c3N3CCC4(CCNC4=O)CC3)ccc21 | Homo sapiens | CHEMBL3803436 | single protein format |
| CHEMBL3799307 |  |
IC50 | = | 2.3 | nM | 448.93 | CN1c2ccc(-c3cncc(Cl)c3N3CCC4(CC3)CNC(=O)O4)cc2CS1(=O)=O | Homo sapiens | CHEMBL3803436 | single protein format |
| CHEMBL3798987 |  |
IC50 | = | 2.4 | nM | 461.93 | CN1c2ccc(-c3cncc(Cl)c3N3CCC4(CC3)NC(=O)NC4=O)cc2CS1(=O)=O | Homo sapiens | CHEMBL3803436 | single protein format |
| CHEMBL3797571 |  |
IC50 | = | 2.4 | nM | 446.96 | CN1c2ccc(-c3cncc(Cl)c3N3CCC4(CCNC4=O)CC3)cc2CS1(=O)=O | Homo sapiens | CHEMBL3803436 | single protein format |