P49327 | FAS_HUMAN | Fatty acid synthase (FASN)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00107 | ADH_zinc_N - Zinc-binding dehydrogenase | 1679~1815 | |
| PF00109 | ketoacyl-synt - Beta-ketoacyl synthase, N-terminal domain | 1~237 | |
| PF00550 | PP-binding - Phosphopantetheine attachment site | 2126~2187 | |
| PF00698 | Acyl_transf_1 - Acyl transferase domain | 493~809 | |
| PF00975 | Thioesterase - Thioesterase domain | 2242~2500 | |
| PF02801 | Ketoacyl-synt_C - Beta-ketoacyl synthase, C-terminal domain | 243~360 | |
| PF08242 | Methyltransf_12 - Methyltransferase domain | 1244~1342 | |
| PF08659 | KR - KR domain | 1886~2064 | |
| PF16197 | KAsynt_C_assoc - Ketoacyl-synthetase C-terminal extension | 362~472 | |
| PF21089 | PKS_DH_N - Polyketide synthase dehydratase domain | 870~947 | |
| PF21149 | FAS_pseudo-KR - Fatty acid synthase, pseudo-KR domain | 1422~1519 |
3D structures mapped by conservation among orthologs
[ Domain: "Alcohol dehydrogenase-like, N-terminal domain" // KOG1202_2nd ]
[ Domain: "alpha/beta-Hydrolases" // Hydrolase_4_1 ]
[ Domain: "alpha/beta-Hydrolases" // UNK_F_TYPE ]
[ Domain: "Thiolase-like" // ketoacyl-synt ]
[ Domain: "Thiolase-like" // Ketoacyl-synt_C ]
[ Domain: "Acyl-carrier protein (ACP)" // PP-binding ]
[ Domain: "Probable ACP-binding domain of malonyl-CoA ACP transacylase" // Acyl_transf_1_2nd ]
[ Domain: "KS-MAT linker domain in fatty acid synthase" // KAsynt_C_assoc ]
[ Domain: "NAD(P)-binding Rossmann-fold domains" // ADH_zinc_N ]
[ Domain: "NAD(P)-binding Rossmann-fold domains" // KOG1202_1st ]
[ Domain: "NAD(P)-binding Rossmann-fold domains" // adh_short_C2_1 ]
[ Domain: "S-adenosyl-L-methionine-dependent methyltransferases" // Methyltransf_11_3 ]
[ Domain: "FabD/lysophospholipase-like" // Acyl_transf_1_1st ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3623457 |  |
IC50 | = | 3.0 | nM | 457.51 | O=C(C1CC1)N1CC[C@@H](Cc2n[nH]c(=O)n2-c2ccc(-c3ccc4ccncc4c3)cc2F)C1 | Homo sapiens | CHEMBL3625457 | single protein format |
| CHEMBL3646811 |  |
IC50 | = | 3.0 | nM | 457.51 | O=C(C1CC1)N1CC[C@@H](Cc2n[nH]c(=O)n2-c2ccc(-c3ccc4cnccc4c3)cc2F)C1 | Homo sapiens | CHEMBL3706007 | single protein format |
| CHEMBL3962197 |  |
IC50 | = | 5.0 | nM | 418.93 | Cc1nc(Cl)c(-c2cc(C(=O)N3CCC(c4ccc(C#N)cc4)CC3)ccc2C)[nH]1 | Homo sapiens | CHEMBL3888977 | cell-based format |
| CHEMBL3646807 |  |
IC50 | = | 5.0 | nM | 441.54 | Cc1cc(-c2ccc3cc[nH]c3c2)ccc1-n1c(C[C@@H]2CCN(C(=O)C3CC3)C2)n[nH]c1=O | Homo sapiens | CHEMBL3706007 | single protein format |
| CHEMBL3623460 |  |
IC50 | = | 6.0 | nM | 477.59 | O=C1COC2(CCN(S(=O)(=O)c3ccc(-c4cccc5cnccc45)cc3)CC2)CN1C1CC1 | Homo sapiens | CHEMBL3625457 | single protein format |
| CHEMBL3915660 |  |
IC50 | = | 6.0 | nM | 436.92 | Cc1nc(Cl)c(-c2cc(C(=O)N3CCC(F)(c4ccc(C#N)cc4)CC3)ccc2C)[nH]1 | Homo sapiens | CHEMBL3888977 | cell-based format |
| CHEMBL3646804 |  |
IC50 | = | 6.0 | nM | 428.49 | O=C(C1CC1)N1CC[C@@H](Cc2n[nH]c(=O)n2-c2ccc(-c3ccc4ccoc4c3)cc2)C1 | Homo sapiens | CHEMBL3706007 | single protein format |
| CHEMBL3975955 |  |
IC50 | = | 6.0 | nM | 390.87 | Cc1nc(Cl)c(-c2cc(C(=O)N3CC(c4ccc(C#N)cc4)C3)ccc2C)[nH]1 | Homo sapiens | CHEMBL3888977 | cell-based format |
| CHEMBL2147033 |  |
IC50 | = | 6.0 | nM | 477.59 | O=C1COC2(CCN(S(=O)(=O)c3ccc(-c4ccc5cnccc5c4)cc3)CC2)CN1C1CC1 | Homo sapiens | CHEMBL2150656 | single protein format |
| CHEMBL3968803 |  |
IC50 | = | 7.0 | nM | 444.97 | Cc1ccc(C(=O)N2CCC(c3ccc(C#N)cc3)CC2)cc1-c1[nH]c(C2CC2)nc1Cl | Homo sapiens | CHEMBL3888977 | cell-based format |
| CHEMBL3949918 |  |
IC50 | = | 7.0 | nM | 416.91 | Cc1ccc(C(=O)N2CC(c3ccc(C#N)cc3)C2)cc1-c1[nH]c(C2CC2)nc1Cl | Homo sapiens | CHEMBL3888977 | cell-based format |
| CHEMBL3623458 |  |
IC50 | = | 7.9 | nM | 492.58 | Cn1ncc2c(=O)n(C[C@@H]3CCN(C(=O)C4CC4)C3)c(-c3ccc(-c4ccc5[nH]ccc5c4)cc3)nc21 | Homo sapiens | CHEMBL3625457 | single protein format |
| CHEMBL3979428 |  |
IC50 | = | 8.0 | nM | 469.55 | COC(=O)N1CC(c2nc(C)c(-c3cc(C(=O)N4CC(c5ccc(C#N)cc5)C4)ccc3C)[nH]2)C1 | Homo sapiens | CHEMBL3888977 | cell-based format |
| CHEMBL3922048 |  |
IC50 | = | 9.0 | nM | 420.9 | Cc1ccc(C(=O)N2CC(c3ccc(C#N)cc3)C2)cc1-c1[nH]c(CCO)nc1Cl | Homo sapiens | CHEMBL3888977 | cell-based format |
| CHEMBL3895704 |  |
IC50 | = | 9.0 | nM | 460.97 | Cc1ccc(C(=O)N2CC(c3ccc(C#N)cc3)C2)cc1-c1[nH]c(C2CCOCC2)nc1Cl | Homo sapiens | CHEMBL3888977 | cell-based format |
| CHEMBL3927497 |  |
IC50 | = | 9.0 | nM | 448.95 | COCc1nc(Cl)c(-c2cc(C(=O)N3CCC(c4ccc(C#N)cc4)CC3)ccc2C)[nH]1 | Homo sapiens | CHEMBL3888977 | cell-based format |
| CHEMBL3975941 |  |
IC50 | = | 9.0 | nM | 418.93 | Cc1ccc(C(=O)N2CC(c3ccc(C#N)cc3)C2)cc1-c1[nH]c(C(C)C)nc1Cl | Homo sapiens | CHEMBL3888977 | cell-based format |
| CHEMBL3940149 |  |
IC50 | = | 9.0 | nM | 462.96 | Cc1ccc(C(=O)N2CCC(F)(c3ccc(C#N)cc3)CC2)cc1-c1[nH]c(C2CC2)nc1Cl | Homo sapiens | CHEMBL3888977 | cell-based format |
| CHEMBL3945625 |  |
IC50 | = | 9.0 | nM | 446.98 | Cc1ccc(C(=O)N2CCC(c3ccc(C#N)cc3)CC2)cc1-c1[nH]c(C(C)C)nc1Cl | Homo sapiens | CHEMBL3888977 | cell-based format |
| CHEMBL3960666 |  |
IC50 | = | 9.0 | nM | 497.6 | COC(=O)N1CCC(c2nc(C)c(-c3cc(C(=O)N4CC(c5ccc(C#N)cc5)C4)ccc3C)[nH]2)CC1 | Homo sapiens | CHEMBL3888977 | cell-based format |