P49281 | NRAM2_HUMAN | Natural resistance-associated macrophage protein 2 (SLC11A2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF01566 | Nramp - Natural resistance-associated macrophage protein-like | 90~473 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3145266 |  |
IC50 | = | 60.0 | nM | 296.29 | Cc1[nH]n(-c2ccccn2)c(=O)c1-c1ccc([N+](=O)[O-])cc1 | Homo sapiens | CHEMBL1936903 | cell-based format |
| CHEMBL2079088 |  |
IC50 | = | 140.0 | nM | 344.47 | N=C(N)SCc1cccc2c1oc1c(CSC(=N)N)cccc12 | Homo sapiens | CHEMBL4700248 | cell-based format |
| CHEMBL1933782 |  |
IC50 | = | 150.0 | nM | 333.42 | Cc1ccc2nc(-n3nc4c(c3O)-c3ccccc3CC4)sc2c1 | Homo sapiens | CHEMBL1936903 | cell-based format |
| CHEMBL3145267 |  |
IC50 | = | 150.0 | nM | 319.29 | Cc1[nH]n(-c2ccccn2)c(=O)c1-c1ccc(C(F)(F)F)cc1 | Homo sapiens | CHEMBL1936903 | cell-based format |
| CHEMBL3145276 |  |
IC50 | = | 170.0 | nM | 362.31 | Cc1[nH]n(-c2ccccn2)c(=O)c1C(=O)Nc1cccc(C(F)(F)F)c1 | Homo sapiens | CHEMBL1936903 | cell-based format |
| CHEMBL3145277 |  |
IC50 | = | 200.0 | nM | 339.31 | Cc1[nH]n(-c2ccccn2)c(=O)c1C(=O)Nc1ccc([N+](=O)[O-])cc1 | Homo sapiens | CHEMBL1936903 | cell-based format |
| CHEMBL1933791 |  |
IC50 | = | 210.0 | nM | 369.42 | COc1ccc(-c2ccc3c(c2)CCc2nn(-c4ccccn4)c(O)c2-3)cc1 | Homo sapiens | CHEMBL1936903 | cell-based format |
| CHEMBL3145278 |  |
IC50 | = | 260.0 | nM | 342.33 | COc1ccc(NC(=O)c2c(C)[nH]n(-c3ccccn3)c2=O)cc1F | Homo sapiens | CHEMBL1936903 | cell-based format |
| CHEMBL1933792 |  |
IC50 | = | 260.0 | nM | 339.4 | Oc1c2c(nn1-c1ccccn1)CCc1cc(-c3ccccc3)ccc1-2 | Homo sapiens | CHEMBL1936903 | cell-based format |
| CHEMBL1933793 |  |
IC50 | = | 270.0 | nM | 353.43 | Cc1ccc(-c2ccc3c(c2)CCc2nn(-c4ccccn4)c(O)c2-3)cc1 | Homo sapiens | CHEMBL1936903 | cell-based format |
| CHEMBL3145279 |  |
IC50 | = | 290.0 | nM | 362.31 | Cc1[nH]n(-c2ccccn2)c(=O)c1C(=O)Nc1ccc(C(F)(F)F)cc1 | Homo sapiens | CHEMBL1936903 | cell-based format |
| CHEMBL1933794 |  |
IC50 | = | 310.0 | nM | 342.2 | Oc1c2c(nn1-c1ccccn1)CCc1cc(Br)ccc1-2 | Homo sapiens | CHEMBL1936903 | cell-based format |
| CHEMBL3145268 |  |
IC50 | = | 320.0 | nM | 319.29 | Cc1[nH]n(-c2ccccn2)c(=O)c1-c1cccc(C(F)(F)F)c1 | Homo sapiens | CHEMBL1936903 | cell-based format |
| CHEMBL1933783 |  |
IC50 | = | 330.0 | nM | 349.42 | COc1ccc2nc(-n3nc4c(c3O)-c3ccccc3CC4)sc2c1 | Homo sapiens | CHEMBL1936903 | cell-based format |
| CHEMBL1197758 |  |
IC50 | = | 350.0 | nM | 296.47 | Cc1cc(C)c(CSC(=N)N)c(C)c1CSC(=N)N | Homo sapiens | CHEMBL4700257 | cell-based format |
| CHEMBL3145265 |  |
IC50 | = | 360.0 | nM | 276.3 | Cc1[nH]n(-c2ccccn2)c(=O)c1-c1ccc(C#N)cc1 | Homo sapiens | CHEMBL1936903 | cell-based format |
| CHEMBL3145274 |  |
IC50 | = | 390.0 | nM | 325.37 | Cc1[nH]n(-c2nc3ccc(F)cc3s2)c(=O)c1-c1ccccc1 | Homo sapiens | CHEMBL1936903 | cell-based format |
| CHEMBL1933784 |  |
IC50 | = | 400.0 | nM | 337.38 | Oc1c2c(nn1-c1nc3ccc(F)cc3s1)CCc1ccccc1-2 | Homo sapiens | CHEMBL1936903 | cell-based format |
| CHEMBL3145257 |  |
IC50 | = | 410.0 | nM | 308.34 | Cc1cccc(NC(=O)c2c(C)[nH]n(-c3ccccn3)c2=O)c1 | Homo sapiens | CHEMBL1936903 | cell-based format |
| CHEMBL3145251 |  |
IC50 | = | 430.0 | nM | 307.38 | Cc1[nH]n(-c2nc3ccccc3s2)c(=O)c1-c1ccccc1 | Homo sapiens | CHEMBL1936903 | cell-based format |