P49238 | CX3C1_HUMAN | CX3C chemokine receptor 1 (CX3CR1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00001 | 7tm_1 - 7 transmembrane receptor (rhodopsin family) | 48~293 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4518556 |  |
IC50 | = | 4.0 | nM | 556.07 | C[C@H]1CN(Cc2c(Cl)cccc2C(F)(F)F)C[C@@]1(CC(=O)O)C(=O)NC1CCN(CC2=CCCCC2)CC1 | Homo sapiens | CHEMBL4418337 | cell-based format |
| CHEMBL4539605 |  |
IC50 | = | 5.0 | nM | 542.04 | C[C@H]1CN(Cc2c(Cl)cccc2C(F)(F)F)C[C@@]1(CC(=O)O)C(=O)NC1CCN(CC2=CCCC2)CC1 | Homo sapiens | CHEMBL4418337 | cell-based format |
| CHEMBL4577003 |  |
IC50 | = | 6.0 | nM | 538.08 | C[C@H]1CN(Cc2c(Cl)cccc2C(F)F)C[C@@]1(CC(=O)O)C(=O)NC1CCN(CC2=CCCCC2)CC1 | Homo sapiens | CHEMBL4418337 | cell-based format |
| CHEMBL4474066 |  |
IC50 | = | 6.0 | nM | 522.52 | C[C@H]1CN(Cc2c(Cl)cccc2Cl)C[C@@]1(CC(=O)O)C(=O)NC1CCN(CC2=CCCCC2)CC1 | Homo sapiens | CHEMBL4418337 | cell-based format |
| CHEMBL4475030 |  |
IC50 | = | 11.0 | nM | 502.1 | Cc1cccc(Cl)c1CN1C[C@H](C)[C@](CC(=O)O)(C(=O)NC2CCN(CC3=CCCCC3)CC2)C1 | Homo sapiens | CHEMBL4418337 | cell-based format |
| CHEMBL4442967 |  |
IC50 | = | 12.0 | nM | 540.1 | C[C@H]1CN(Cc2c(Cl)cccc2C(F)F)C[C@@]1(CC(=O)O)C(=O)NC1CCN(CC2CCCCC2)CC1 | Homo sapiens | CHEMBL4418337 | cell-based format |
| CHEMBL4565523 |  |
IC50 | = | 13.0 | nM | 550.04 | CCCC(F)CN1CCC(NC(=O)[C@]2(CC(=O)O)CN(Cc3c(Cl)cccc3C(F)(F)F)C[C@@H]2C)CC1 | Homo sapiens | CHEMBL4418337 | cell-based format |
| CHEMBL4551880 |  |
IC50 | = | 14.0 | nM | 528.08 | CCCCCCN1CCC(NC(=O)[C@]2(CC(=O)O)CN(Cc3c(Cl)cccc3C(F)F)C[C@@H]2C)CC1 | Homo sapiens | CHEMBL4418337 | cell-based format |
| CHEMBL4435586 |  |
IC50 | = | 16.0 | nM | 524.05 | C[C@H]1CN(Cc2c(Cl)cccc2C(F)F)C[C@@]1(CC(=O)O)C(=O)NC1CCN(CC2=CCCC2)CC1 | Homo sapiens | CHEMBL4418337 | cell-based format |
| CHEMBL4443425 |  |
IC50 | = | 16.0 | nM | 508.49 | C[C@H]1CN(Cc2c(Cl)cccc2Cl)C[C@@]1(CC(=O)O)C(=O)N[C@H]1CCN(CC2=CCCCC2)C1 | Homo sapiens | CHEMBL4418337 | cell-based format |
| CHEMBL4456446 |  |
IC50 | = | 21.0 | nM | 560.51 | C[C@H]1CN(Cc2c(Cl)cccc2Cl)C[C@@]1(CC(=O)O)C(=O)NC1CCN(CC2CCC(F)(F)CC2)CC1 | Homo sapiens | CHEMBL4418337 | cell-based format |
| CHEMBL4447653 |  |
IC50 | = | 31.0 | nM | 488.07 | Cc1cccc(Cl)c1CN1C[C@H](C)[C@](CC(=O)O)(C(=O)NC2CCN(CC3=CCCC3)CC2)C1 | Homo sapiens | CHEMBL4418337 | cell-based format |
| CHEMBL2349310 |  |
Ki | = | 3.9 | nM | 403.58 | CC(C)C[C@H](CO)Nc1nc(S[C@@H](C)c2ccccc2)nc2nc(N)sc12 | Homo sapiens | CHEMBL2351085 | cell-based format |
| CHEMBL2349322 |  |
Ki | = | 4.0 | nM | 468.45 | CC(C)C[C@H](CO)Nc1nc(SCc2ccccc2Br)nc2nc(N)sc12 | Homo sapiens | CHEMBL2351085 | cell-based format |
| CHEMBL2349316 |  |
Ki | = | 4.7 | nM | 421.57 | CC(C)C[C@H](CO)Nc1nc(S[C@@H](C)c2ccccc2F)nc2nc(N)sc12 | Homo sapiens | CHEMBL2351085 | cell-based format |
| CHEMBL2349180 |  |
Ki | = | 5.8 | nM | 439.99 | CC(C)C[C@H](CO)Nc1nc(S[C@@H](C)c2cc(Cl)ccn2)nc2[nH]c(=O)sc12 | Homo sapiens | CHEMBL2351085 | cell-based format |
| CHEMBL2349179 |  |
Ki | = | 6.2 | nM | 439.01 | CC(C)C[C@H](CO)Nc1nc(S[C@@H](C)c2cc(Cl)ccn2)nc2nc(N)sc12 | Homo sapiens | CHEMBL2351085 | cell-based format |
| CHEMBL2349312 |  |
Ki | = | 7.8 | nM | 404.56 | CC(C)C[C@H](CO)Nc1nc(S[C@@H](C)c2ccccc2)nc2[nH]c(=O)sc12 | Homo sapiens | CHEMBL2351085 | cell-based format |
| CHEMBL2349313 |  |
Ki | = | 8.0 | nM | 404.56 | CC(C)C[C@H](CO)Nc1nc(S[C@H](C)c2ccccc2)nc2[nH]c(=O)sc12 | Homo sapiens | CHEMBL2351085 | cell-based format |
| CHEMBL2349332 |  |
Ki | = | 8.1 | nM | 486.44 | CC(C)C[C@H](CO)Nc1nc(SCc2ccc(Br)cc2F)nc2nc(N)sc12 | Homo sapiens | CHEMBL2351085 | cell-based format |