P49146 | NPY2R_HUMAN | Neuropeptide Y receptor type 2 (NPY2R)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00001 | 7tm_1 - 7 transmembrane receptor (rhodopsin family) | 67~325 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4128926 |  |
IC50 | = | 0.28 | nM | 583.78 | CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12 | Homo sapiens | CHEMBL4121492 | single protein format |
| CHEMBL1823342 |  |
IC50 | = | 6.0 | nM | 565.69 | CCN(CC)C(=O)C(c1ccccc1)N1CCN(c2ccc(NC(=O)c3ccccc3-c3cccnc3)cc2F)CC1 | Homo sapiens | CHEMBL1827365 | cell-based format |
| CHEMBL2403023 |  |
IC50 | = | 7.0 | nM | 564.71 | CCN(CC)C(=O)C(c1ccccc1)C1CCN(c2ccc(NC(=O)c3ccccc3-c3cccnc3)cc2F)CC1 | Homo sapiens | CHEMBL2404394 | cell-based format |
| CHEMBL3104181 |  |
IC50 | = | 7.0 | nM | 475.57 | CCC(CC)C(=O)Nc1ccc(N2CCN(C(c3cccc(F)c3)c3ncco3)CC2)c(C#N)c1 | Homo sapiens | CHEMBL3107076 | single protein format |
| CHEMBL1823577 |  |
IC50 | = | 9.0 | nM | 565.69 | CCN(CC)C(=O)[C@@H](c1ccccc1)N1CCN(c2ccc(NC(=O)c3ccccc3-c3cccnc3)cc2F)CC1 | Homo sapiens | CHEMBL1827365 | cell-based format |
| CHEMBL1823360 |  |
IC50 | = | 10.0 | nM | 564.71 | CCN(CC)C(=O)C(c1ccccc1)N1CCN(c2ccc(NC(=O)c3ccccc3-c3ccccc3)cc2F)CC1 | Homo sapiens | CHEMBL1827365 | cell-based format |
| CHEMBL3104180 |  |
IC50 | = | 11.0 | nM | 486.62 | CCN(CC)C(=O)C(c1ccccc1)N1CCN(c2ccc(-c3nc(C(C)C)no3)cc2C#N)CC1 | Homo sapiens | CHEMBL3107076 | single protein format |
| CHEMBL1823354 |  |
IC50 | = | 11.0 | nM | 543.67 | CCNC(=O)C(c1ccccc1)N1CCN(c2ccc(NC(=O)c3ccccc3-c3ccccc3)cc2C#N)CC1 | Homo sapiens | CHEMBL1827365 | cell-based format |
| CHEMBL2403028 |  |
IC50 | = | 12.0 | nM | 521.64 | CCN(CC)C(=O)C(c1ccccc1)C1CCN(c2ccc(NC(=O)Nc3c(C)noc3C)cc2F)CC1 | Homo sapiens | CHEMBL2404394 | cell-based format |
| CHEMBL3104200 |  |
IC50 | = | 12.0 | nM | 481.66 | CCC(CC)C(=O)Nc1ccc(N2CCC(C(C(=O)N(CC)CC)c3ccccc3)CC2)c(F)c1 | Homo sapiens | CHEMBL3107076 | single protein format |
| CHEMBL2402905 |  |
IC50 | = | 12.0 | nM | 535.66 | CCNC(=O)C(c1ccccc1)C1CCN(c2ccc(NC(=O)c3ccccc3-c3ccccc3)cc2F)CC1 | Homo sapiens | CHEMBL2404394 | cell-based format |
| CHEMBL3104202 |  |
IC50 | = | 14.0 | nM | 520.65 | CCN(CC)C(=O)C(c1ccccc1)C1CCN(c2ccc(NC(=O)Cc3c(C)noc3C)cc2F)CC1 | Homo sapiens | CHEMBL3107076 | single protein format |
| CHEMBL1823578 |  |
IC50 | = | 14.0 | nM | 565.69 | CCN(CC)C(=O)[C@H](c1ccccc1)N1CCN(c2ccc(NC(=O)c3ccccc3-c3cccnc3)cc2F)CC1 | Homo sapiens | CHEMBL1827365 | cell-based format |
| CHEMBL2403027 |  |
IC50 | = | 15.0 | nM | 493.58 | CCNC(=O)C(c1ccccc1)C1CCN(c2ccc(NC(=O)Nc3c(C)noc3C)cc2F)CC1 | Homo sapiens | CHEMBL2404394 | cell-based format |
| CHEMBL3104205 |  |
IC50 | = | 16.0 | nM | 522.63 | CCN(CC)C(=O)C(c1ccccc1)N1CCN(c2ccc(NC(=O)Nc3c(C)noc3C)cc2F)CC1 | Homo sapiens | CHEMBL3107076 | single protein format |
| CHEMBL3104194 |  |
IC50 | = | 18.0 | nM | 512.67 | CCC(CC)C(=O)Nc1ccc(N2CCN(C(C(=O)N(CC)CC)c3ccc(OC)cc3)CC2)c(F)c1 | Homo sapiens | CHEMBL3107076 | single protein format |
| CHEMBL3104207 |  |
IC50 | = | 20.0 | nM | 556.73 | CCN(CC)C(=O)C(c1ccccc1)N1CCN(c2ccc(NC(=O)C3(c4ccccc4)CCCC3)cc2F)CC1 | Homo sapiens | CHEMBL3107076 | single protein format |
| CHEMBL3104204 |  |
IC50 | = | 20.0 | nM | 521.64 | CCN(CC)C(=O)C(c1ccccc1)N1CCN(c2ccc(NC(=O)Cc3c(C)noc3C)cc2F)CC1 | Homo sapiens | CHEMBL3107076 | single protein format |
| CHEMBL2402906 |  |
IC50 | = | 24.0 | nM | 536.65 | CCNC(=O)C(c1ccccc1)C1CCN(c2ccc(NC(=O)c3ccccc3-c3cccnc3)cc2F)CC1 | Homo sapiens | CHEMBL2404394 | cell-based format |
| CHEMBL3104201 |  |
IC50 | = | 25.0 | nM | 481.61 | CCN(CC)C(=O)C(c1ccccc1)C1CCN(c2ccc(NC(=O)C3CCOC3)cc2F)CC1 | Homo sapiens | CHEMBL3107076 | single protein format |