P49137 | MAPK2_HUMAN | MAP kinase-activated protein kinase 2 (MAPKAPK2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 67~325 |
3D structures mapped by conservation among orthologs
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL561334 |  |
IC50 | = | 1.0 | nM | 283.36 | C[C@@H]1CNc2c(sc3ccc4ncccc4c23)C(=O)N1 | Homo sapiens | CHEMBL1061558 | single protein format |
| CHEMBL1801384 |  |
IC50 | = | 1.0 | nM | 438.53 | O=C1NCCc2[nH]c3c(ccc4cnc(/C=C/c5ccc(CN6CCOCC6)cc5)cc43)c21 | Homo sapiens | CHEMBL1805901 | single protein format |
| CHEMBL2385548 |  |
IC50 | = | 1.9 | nM | 552.64 | N#Cc1ccc(-c2cc3c(o2)C(=O)N(Cc2ccccc2-c2cncnc2)c2ccc(N4CCNCC4)cc2C3)cc1 | Homo sapiens | CHEMBL2389966 | single protein format |
| CHEMBL556392 |  |
IC50 | = | 2.0 | nM | 317.8 | C[C@@H]1CNc2c(sc3ccc4nc(Cl)ccc4c23)C(=O)N1 | Homo sapiens | CHEMBL1061558 | single protein format |
| CHEMBL257834 |  |
IC50 | = | 2.0 | nM | 548.71 | CC(C)(C)CN1CCC(NC(=O)c2csc(NC(=O)c3ccc4cc5n(c4c3)C3(CCC3)CNC5=O)n2)CC1 | Homo sapiens | CHEMBL949020 | single protein format |
| CHEMBL258045 |  |
IC50 | = | 2.0 | nM | 492.61 | CN1CCC(NC(=O)c2csc(NC(=O)c3ccc4cc5n(c4c3)C3(CCC3)CNC5=O)n2)CC1 | Homo sapiens | CHEMBL949020 | single protein format |
| CHEMBL403154 |  |
IC50 | = | 2.0 | nM | 536.7 | CC(C)(C)CN1CCC(NC(=O)c2csc(NC(=O)c3ccc4cc5n(c4c3)C(C)(C)CNC5=O)n2)CC1 | Homo sapiens | CHEMBL949020 | single protein format |
| CHEMBL1938685 |  |
IC50 | = | 2.9 | nM | 407.48 | N#Cc1ccc(-c2cc3c(o2)-c2nccn2-c2ccc(N4CCNCC4)cc2C3)cc1 | Homo sapiens | CHEMBL1942718 | single protein format |
| CHEMBL1801308 |  |
IC50 | < | 3.0 | nM | 500.6 | CN1CC2(CNC(=O)c3c2[nH]c2c3CCc3cnc(-c4ccc(OCCN5CCOCC5)cc4)nc3-2)C1 | Homo sapiens | CHEMBL1805885 | single protein format |
| CHEMBL2385549 |  |
IC50 | = | 3.0 | nM | 551.65 | N#Cc1ccc(-c2cc3c(o2)C(=O)N(Cc2ccccc2-c2cncnc2)c2ccc(C4CCNCC4)cc2C3)cc1 | Homo sapiens | CHEMBL2389966 | single protein format |
| CHEMBL1801306 |  |
IC50 | < | 3.0 | nM | 401.47 | COc1ccc(-c2ncc3c(n2)-c2[nH]c4c(c2CC3)C(=O)NCC42CN(C)C2)cc1 | Homo sapiens | CHEMBL1805885 | single protein format |
| CHEMBL403258 |  |
IC50 | = | 3.0 | nM | 568.7 | O=C(Nc1nc(C(=O)NC2CCN(Cc3ccccc3)CC2)cs1)c1ccc2cc3n(c2c1)C1(CCC1)CNC3=O | Homo sapiens | CHEMBL949020 | single protein format |
| CHEMBL256194 |  |
IC50 | = | 3.0 | nM | 522.68 | CC1CNC(=O)c2cc3ccc(C(=O)Nc4nc(C(=O)NC5CCN(CC(C)(C)C)CC5)cs4)cc3n21 | Homo sapiens | CHEMBL949020 | single protein format |
| CHEMBL1801286 |  |
IC50 | < | 3.0 | nM | 459.55 | COCCCOc1cncc(-c2cc3c(cn2)CCc2c-3[nH]c3c2C(=O)NCC32CN(C)C2)c1 | Homo sapiens | CHEMBL1805885 | single protein format |
| CHEMBL1801289 |  |
IC50 | < | 3.0 | nM | 389.43 | CN1CC2(CNC(=O)c3c2[nH]c2c3CCc3cnc(-c4ccc(F)nc4)cc3-2)C1 | Homo sapiens | CHEMBL1805885 | single protein format |
| CHEMBL1801290 |  |
IC50 | < | 3.0 | nM | 499.62 | CN1CC2(CNC(=O)c3c2[nH]c2c3CCc3cnc(-c4ccc(OCCN5CCOCC5)cc4)cc3-2)C1 | Homo sapiens | CHEMBL1805885 | single protein format |
| CHEMBL1801291 |  |
IC50 | < | 3.0 | nM | 402.47 | CCN1CC2(CNC(=O)c3c2[nH]c2c3CCc3cnc(-c4ccccc4F)cc3-2)C1 | Homo sapiens | CHEMBL1805885 | single protein format |
| CHEMBL1938687 |  |
IC50 | = | 3.8 | nM | 408.47 | N#Cc1ccc(-c2cc3c(o2)-c2nncn2-c2ccc(N4CCNCC4)cc2C3)cc1 | Homo sapiens | CHEMBL1942718 | single protein format |
| CHEMBL255991 |  |
IC50 | = | 4.0 | nM | 508.65 | CC(C)CN1CCC(NC(=O)c2csc(NC(=O)c3ccc4cc5n(c4c3)C(C)CNC5=O)n2)CC1 | Homo sapiens | CHEMBL949020 | single protein format |
| CHEMBL1801296 |  |
IC50 | = | 4.0 | nM | 416.5 | CN1CCC2(CC1)CNC(=O)c1c2[nH]c2c1CCc1cnc(-c3ccccc3F)cc1-2 | Homo sapiens | CHEMBL1805885 | single protein format |