P48775 | T23O_HUMAN | Tryptophan 2,3-dioxygenase (TDO2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF03301 | Trp_dioxygenase - Tryptophan 2,3-dioxygenase | 27~372 |
3D structures mapped by conservation among orthologs
[ Domain: "Indolic compounds 2,3-dioxygenase-like" // Trp_dioxygenase ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5220107 |  |
IC50 | = | 3.42 | nM | 375.24 | CC1=C(CC(=O)c2sccc2Br)C(=O)c2ccccc2C1=O | Homo sapiens | CHEMBL5216263 | cell-based format |
| CHEMBL4787695 |  |
IC50 | = | 4.0 | nM | 345.69 | O=C1c2cc(F)ccc2C(=O)c2c1nnn2-c1ccc(F)c(Cl)c1 | Homo sapiens | CHEMBL4709781 | single protein format |
| CHEMBL4765090 |  |
IC50 | = | 10.0 | nM | 345.69 | O=C1c2ccc(F)cc2C(=O)c2c1nnn2-c1ccc(F)c(Cl)c1 | Homo sapiens | CHEMBL4709781 | single protein format |
| CHEMBL4756155 |  |
IC50 | = | 14.0 | nM | 327.7 | O=C1c2ccccc2C(=O)c2c1nnn2-c1ccc(F)c(Cl)c1 | Homo sapiens | CHEMBL4709781 | single protein format |
| CHEMBL4747779 |  |
IC50 | = | 15.0 | nM | 354.71 | O=C1c2ccccc2C(=O)c2c1nnn2-c1ccc(Cl)c([N+](=O)[O-])c1 | Homo sapiens | CHEMBL4709781 | single protein format |
| CHEMBL4780314 |  |
IC50 | = | 15.0 | nM | 309.71 | O=C1c2ccccc2C(=O)c2c1nnn2-c1ccc(Cl)cc1 | Homo sapiens | CHEMBL4709781 | single protein format |
| CHEMBL4791729 |  |
IC50 | = | 18.0 | nM | 327.7 | O=C1c2ccccc2C(=O)c2c1nnn2-c1ccc(Cl)c(F)c1 | Homo sapiens | CHEMBL4709781 | single protein format |
| CHEMBL4753714 |  |
IC50 | = | 18.0 | nM | 344.16 | O=C1c2ccccc2C(=O)c2c1nnn2-c1ccc(Cl)c(Cl)c1 | Homo sapiens | CHEMBL4709781 | single protein format |
| CHEMBL4466645 |  |
IC50 | = | 20.0 | nM | 200.24 | OCCC1c2ccccc2-c2cncn21 | Homo sapiens | CHEMBL4345896 | single protein format |
| CHEMBL4434743 |  |
IC50 | = | 20.0 | nM | 201.23 | OCCn1c2ccccc2c2cncn21 | Homo sapiens | CHEMBL4345896 | single protein format |
| CHEMBL4862796 |  |
IC50 | = | 20.0 | nM | 252.25 | Fc1ccc2c(-c3ccc4[nH]nnc4c3)c[nH]c2c1 | Homo sapiens | CHEMBL4810616 | cell-based format |
| CHEMBL4798028 |  |
IC50 | = | 21.0 | nM | 276.26 | O=C1c2ccccc2C(=O)c2c1nnn2-c1cccnc1 | Homo sapiens | CHEMBL4709781 | single protein format |
| CHEMBL4642346 |  |
IC50 | = | 25.0 | nM | 310.7 | O=C1c2ccccc2C(=O)c2c1nnn2-c1ccc(Cl)nc1 | Homo sapiens | CHEMBL4709781 | single protein format |
| CHEMBL4747079 |  |
IC50 | = | 25.0 | nM | 361.76 | CCNC1=C/C(=N\c2ccc(F)c(Cl)c2)c2cc(C(=O)O)[nH]c2C1=O | Homo sapiens | CHEMBL4682950 | single protein format |
| CHEMBL4785841 |  |
IC50 | = | 25.0 | nM | 377.71 | O=C1c2ccccc2C(=O)c2c1nnn2-c1ccc(C(F)(F)F)c(Cl)c1 | Homo sapiens | CHEMBL4709781 | single protein format |
| CHEMBL4783665 |  |
IC50 | = | 25.0 | nM | 343.31 | O=C1c2ccccc2C(=O)c2c1nnn2-c1ccc(-c2nnn[nH]2)cc1 | Homo sapiens | CHEMBL4709781 | single protein format |
| CHEMBL3947656 |  |
IC50 | = | 26.0 | nM | 373.41 | CC1c2cc(-c3c[nH]c4cc(F)ccc34)ccc2S(=O)(=O)N1CC(N)=O | Homo sapiens | CHEMBL3871117 | cell-based format |
| CHEMBL3941937 |  |
IC50 | = | 27.0 | nM | 316.36 | C[C@H]1NS(=O)(=O)c2ccc(-c3c[nH]c4cc(F)ccc34)cc21 | Homo sapiens | CHEMBL3871117 | cell-based format |
| CHEMBL4173485 |  |
IC50 | = | 28.0 | nM | 166.2 | Nc1oncc1-c1ccsc1 | Homo sapiens | CHEMBL4149710 | single protein format |
| CHEMBL4777219 |  |
IC50 | = | 28.0 | nM | 320.26 | O=C1c2ccccc2C(=O)c2c1nnn2-c1cccc([N+](=O)[O-])c1 | Homo sapiens | CHEMBL4709781 | single protein format |