P48764 | SL9A3_HUMAN | Sodium/hydrogen exchanger 3 (SLC9A3)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00999 | Na_H_Exchanger - Sodium/hydrogen exchanger, transmembrane | 62~462 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3904640 |  |
IC50 | = | 0.2 | nM | 525.29 | N[C@@H]1CCCN([C@H]2Cc3c(Cl)cc(Cl)cc3[C@@H]2Oc2ccc(S(N)(=O)=O)c(Cl)c2Cl)C1 | Homo sapiens | CHEMBL3861031 | cell-based format |
| CHEMBL3967635 |  |
IC50 | = | 2.0 | nM | 489.85 | CS(=O)(=O)c1ccc(O[C@H]2c3cc(Cl)cc(Cl)c3C[C@@H]2N2CCCNCC2)c(Cl)c1 | Homo sapiens | CHEMBL3861031 | cell-based format |
| CHEMBL3946835 |  |
IC50 | = | 4.0 | nM | 455.41 | CS(=O)(=O)c1ccc(O[C@H]2c3cc(Cl)cc(Cl)c3C[C@@H]2N2CCC[C@@H](N)C2)cc1 | Homo sapiens | CHEMBL3861031 | cell-based format |
| CHEMBL3978001 |  |
IC50 | = | 4.0 | nM | 499.46 | CS(=O)(=O)c1ccc(O[C@H]2c3cc(Cl)cc(Cl)c3C[C@@H]2N2CCC[C@@H](NCCO)C2)cc1 | Homo sapiens | CHEMBL3861031 | cell-based format |
| CHEMBL3914729 |  |
IC50 | = | 6.0 | nM | 455.41 | CS(=O)(=O)c1ccc(O[C@H]2c3cc(Cl)cc(Cl)c3C[C@@H]2N2CCCNCC2)cc1 | Homo sapiens | CHEMBL3861031 | cell-based format |
| CHEMBL3943277 |  |
IC50 | = | 11.0 | nM | 481.45 | CS(=O)(=O)c1ccc(O[C@H]2c3cc(Cl)cc(Cl)c3C[C@@H]2N2CCC3(CCNC3)C2)cc1 | Homo sapiens | CHEMBL3861031 | cell-based format |
| CHEMBL3954374 |  |
IC50 | = | 17.0 | nM | 486.45 | Cc1nnc(C)n1-c1ccc(O[C@H]2c3cc(Cl)cc(Cl)c3C[C@@H]2N2CCCN(C)CC2)cc1 | Homo sapiens | CHEMBL3861031 | cell-based format |
| CHEMBL3897683 |  |
IC50 | = | 20.0 | nM | 342.4 | C/C(=C\c1cc(C)ccc1/C=C(\C)C(=O)NC(=N)N)C(=O)N=C(N)N | Homo sapiens | CHEMBL3881461 | cell-based format |
| CHEMBL3895884 |  |
IC50 | = | 20.0 | nM | 457.42 | CN(C)CCN(C)[C@H]1Cc2c(Cl)cc(Cl)cc2[C@@H]1Oc1ccc(S(C)(=O)=O)cc1 | Homo sapiens | CHEMBL3861031 | cell-based format |
| CHEMBL3916229 |  |
IC50 | = | 20.0 | nM | 455.41 | C[C@@H]1CN([C@H]2Cc3c(Cl)cc(Cl)cc3[C@@H]2Oc2ccc(S(C)(=O)=O)cc2)CCN1 | Homo sapiens | CHEMBL3861031 | cell-based format |
| CHEMBL3893158 |  |
IC50 | = | 22.0 | nM | 441.38 | CS(=O)(=O)c1ccc(O[C@H]2c3cc(Cl)cc(Cl)c3C[C@@H]2N2CCNCC2)cc1 | Homo sapiens | CHEMBL3861031 | cell-based format |
| CHEMBL3938033 |  |
IC50 | = | 23.0 | nM | 472.42 | Cc1nnc(C)n1-c1ccc(O[C@H]2c3cc(Cl)cc(Cl)c3C[C@@H]2N2CCCNCC2)cc1 | Homo sapiens | CHEMBL3861031 | cell-based format |
| CHEMBL3947901 |  |
IC50 | = | 23.0 | nM | 443.38 | N[C@@H]1CCCN([C@H]2Cc3c(Cl)cc(Cl)cc3[C@@H]2Oc2ccc(-n3ccnc3)cc2)C1 | Homo sapiens | CHEMBL3861031 | cell-based format |
| CHEMBL3921160 |  |
IC50 | = | 28.0 | nM | 467.42 | CS(=O)(=O)c1ccc(O[C@H]2c3cc(Cl)cc(Cl)c3C[C@@H]2N2C[C@H]3CNC[C@H]3C2)cc1 | Homo sapiens | CHEMBL3861031 | cell-based format |
| CHEMBL3920102 |  |
IC50 | = | 30.0 | nM | 444.37 | N[C@@H]1CCCN([C@H]2Cc3c(Cl)cc(Cl)cc3[C@@H]2Oc2ccc(-n3cncn3)cc2)C1 | Homo sapiens | CHEMBL3861031 | cell-based format |
| CHEMBL3894965 |  |
IC50 | = | 30.0 | nM | 499.46 | CS(=O)(=O)c1ccc(O[C@H]2c3cc(Cl)cc(Cl)c3C[C@@H]2N2CCCN(CCO)CC2)cc1 | Homo sapiens | CHEMBL3861031 | cell-based format |
| CHEMBL3949677 |  |
IC50 | = | 34.0 | nM | 477.37 | Cc1nnc(C)n1-c1ccc(O[C@H]2c3cc(Cl)cc(Cl)c3C[C@@H]2N2CC[C@@H](O)C2)c(F)c1 | Homo sapiens | CHEMBL3861031 | cell-based format |
| CHEMBL3916425 |  |
IC50 | = | 43.0 | nM | 455.41 | CS(=O)(=O)c1ccc(O[C@H]2c3c(ccc(Cl)c3Cl)C[C@@H]2N2CCCNCC2)cc1 | Homo sapiens | CHEMBL3861031 | cell-based format |
| CHEMBL3905100 |  |
IC50 | = | 48.0 | nM | 471.45 | CN(C)CCCN(C)[C@H]1Cc2c(Cl)cc(Cl)cc2[C@@H]1Oc1ccc(S(C)(=O)=O)cc1 | Homo sapiens | CHEMBL3861031 | cell-based format |
| CHEMBL3907461 |  |
IC50 | = | 56.0 | nM | 501.45 | CS(=O)(=O)c1ccc(O[C@H]2c3cc(Cl)cc(Cl)c3C[C@@H]2N2CCC[C@@H](NCCF)C2)cc1 | Homo sapiens | CHEMBL3861031 | cell-based format |