P48736 | PK3CG_HUMAN | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (PIK3CG)

Pfam Domain Table

AccessionDomainRangeColor
PF00454PI3_PI4_kinase - Phosphatidylinositol 3- and 4-kinase828~1043
PF00613PI3Ka - Phosphoinositide 3-kinase family, accessory domain (PIK domain)544~732
PF00792PI3K_C2 - Phosphoinositide 3-kinase C2380~495
PF00794PI3K_rbd - PI3-kinase family, ras-binding domain204~310
PF19710PIK3CG_ABD - PIK3 catalytic subunit gamma adaptor-binding domain1~192

3D structures mapped by conservation among orthologs

[ Domain: "C2 domain" // PI3K_C2 ]

 PyMOL session

[ Domain: "ARM repeat" // PI3Ka ]

 PyMOL session

[ Domain: "Ubiquitin-like" // PI3K_rbd ]

 PyMOL session

[ Domain: "Protein kinase" // PI3_PI4_kinase ]

 PyMOL session


[ Alpha Fold Model ] (go)



Known binders annotated in ChEMBL

 IC50 CSV    Ki CSV
Only the first 20 rows are shown.
molecule_chembl_idstructureassay_typerelation valueunitmol_wtsmilesorganism assay_chembl_idbao_label
CHEMBL4168702 IC50 = 0.3 nM 507.55 COc1cc(-c2c[nH]c3ncnc(N[C@@H](C)c4nn5ccc(C)c5c(=O)n4-c4ccccc4)c23)ccc1O Homo sapiens CHEMBL4158778 single protein format
CHEMBL4217725 IC50 = 0.5 nM 461.93 O=S(=O)(Nc1cc(-c2cnc3[nH]cc(-c4ccncc4)c3c2)cnc1Cl)c1ccccc1 Homo sapiens CHEMBL4193871 assay format
CHEMBL4780201 IC50 = 0.58 nM 553.55 COc1ncc(-c2ccc3ncnc(Nc4cnn(CCO)c4)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F Homo sapiens CHEMBL4667355 single protein format
CHEMBL1236962 IC50 = 0.6 nM 505.51 COc1ncc(-c2ccc3nccc(-c4ccnnc4)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F Homo sapiens CHEMBL3768550 single protein format
CHEMBL2381271 IC50 = 0.6 nM 392.49 CC(C)n1ncnc1-c1nc2c(s1)CCOc1cc(-c3cn(C)cn3)ccc1-2 Homo sapiens CHEMBL2383016 cell-based format
CHEMBL3901855 IC50 = 0.6 nM 495.52 Cc1ccn2nc([C@H](C)Nc3ncnc4[nH]cc(-c5cc(O)cc(F)c5)c34)n(-c3ccccc3)c(=O)c12 Homo sapiens CHEMBL4158778 single protein format
CHEMBL4176898 IC50 = 0.7 nM 477.53 Cc1ccn2nc([C@H](C)Nc3ncnc4[nH]cc(-c5ccc(O)cc5)c34)n(-c3ccccc3)c(=O)c12 Homo sapiens CHEMBL4158778 single protein format
CHEMBL4166977 IC50 = 0.7 nM 570.64 Cc1ccn2nc([C@H](C)Nc3ncnc4[nH]cc(-c5cc(O)cc(NS(C)(=O)=O)c5)c34)n(-c3ccccc3)c(=O)c12 Homo sapiens CHEMBL4158778 single protein format
CHEMBL4213317 IC50 = 0.7 nM 479.92 O=S(=O)(Nc1cc(-c2cnc3[nH]cc(-c4ccncc4)c3c2)cnc1Cl)c1ccccc1F Homo sapiens CHEMBL4193871 assay format
CHEMBL4208385 IC50 = 0.7 nM 479.92 O=S(=O)(Nc1cc(-c2cnc3[nH]cc(-c4ccncc4)c3c2)cnc1Cl)c1ccc(F)cc1 Homo sapiens CHEMBL4193871 assay format
CHEMBL2381269 IC50 = 0.7 nM 378.46 CC(C)n1ncnc1-c1nc2c(s1)CCOc1cc(-c3cn[nH]c3)ccc1-2 Homo sapiens CHEMBL2383016 cell-based format
CHEMBL5220911 IC50 = 0.71 nM 541.01 CC(=O)N1CCN(c2cnc3ccc(-c4cnc(Cl)c(NS(=O)(=O)c5ccc(F)cc5)c4)cc3n2)CC1 Homo sapiens CHEMBL5216208 single protein format
CHEMBL3968925 IC50 = 0.74 nM 584.61 COc1ncc(-c2ccc3nccc(-c4ccc(Cn5cncn5)cc4)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F Homo sapiens CHEMBL3867036 single protein format
CHEMBL4174909 IC50 = 0.93 nM 557.58 CNc1nc(C)c2cc(-c3cnc(OC)c(NS(=O)(=O)c4ccc(F)cc4F)c3)cc(O[C@@H]3CCOC3)c2n1 Homo sapiens CHEMBL4150389 single protein format
CHEMBL4288258 IC50 = 1.0 nM 478.86 COc1ncc(-c2ccc3ncc(Cl)c(=O)n3c2)cc1NS(=O)(=O)c1ccc(F)cc1F Homo sapiens CHEMBL4255948 single protein format
CHEMBL4740423 IC50 = 1.0 nM 563.58 CC(C)c1cc(-c2c(N)nn3ccc(-c4cc5c(c(C(F)(F)F)c4)C(=O)N([C@@H](C)C4CC4)C5)nc23)ccc1C(=O)O Homo sapiens CHEMBL4670192 cell-based format
CHEMBL3905146 IC50 = 1.1 nM 590.65 COc1ncc(-c2ccc3nccc(-c4ccc(CN(C)CCO)cc4)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F Homo sapiens CHEMBL3867036 single protein format
CHEMBL4749505 IC50 = 1.2 nM 505.62 Cc1cc(-c2cnc3[nH]cc(-c4cc(C)c(C(=O)O)c(C5CC5)c4)c3c2)cc2c1C(=O)N([C@@H](C)C1CC1)C2 Homo sapiens CHEMBL4731655 single protein format
CHEMBL4740643 IC50 = 1.2 nM 519.52 Cc1cc(-c2c[nH]c3ncc(-c4cc5c(c(C(F)(F)F)c4)C(=O)N([C@@H](C)C4CC4)C5)cc23)ccc1C(=O)O Homo sapiens CHEMBL4731655 single protein format
CHEMBL4176771 IC50 = 1.2 nM 543.55 COc1ncc(-c2cc(O[C@@H]3CCOC3)c3nc(N)nc(C)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F Homo sapiens CHEMBL4150389 single protein format