P48735 | IDHP_HUMAN | Isocitrate dehydrogenase [NADP], mitochondrial (IDH2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00180 | Iso_dh - Isocitrate/isopropylmalate dehydrogenase | 45~434 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4278420 |  |
IC50 | = | 4.0 | nM | 358.88 | C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(-c2cccc(Cl)n2)n1)C1CC1 | Homo sapiens | CHEMBL4338886 | cell-based format |
| CHEMBL5415614 |  |
IC50 | = | 4.78 | nM | 539.36 | O[C@@]1(C(F)(F)F)CCN(c2nc(Nc3ccnc(C(F)(F)F)c3)nc(-c3cccc(C(F)(F)F)n3)n2)C1 | Homo sapiens | CHEMBL5368517 | single protein format |
| CHEMBL4463644 |  |
IC50 | = | 6.0 | nM | 469.91 | C[C@H](Nc1nc(N2C(=O)OC[C@@H]2[C@H](C)F)c2cc[nH]c2n1)c1cn(-c2ccc(Cl)cc2)cn1 | Homo sapiens | CHEMBL4309388 | single protein format |
| CHEMBL4280132 |  |
IC50 | = | 6.0 | nM | 430.84 | FC1(F)CCC(Nc2nc(NC3CCC(F)(F)C3)nc(-c3cccc(Cl)n3)n2)C1 | Homo sapiens | CHEMBL4338886 | cell-based format |
| CHEMBL4439421 |  |
IC50 | = | 6.0 | nM | 525.54 | Cc1cc([C@@H](C)Nc2nc(N3C(=O)OC[C@@H]3C(C)C)c3cc[nH]c3n2)ncc1-c1ccnc(C(F)(F)F)c1 | Homo sapiens | CHEMBL4309388 | single protein format |
| CHEMBL4753099 |  |
IC50 | = | 6.1 | nM | 482.43 | FC(F)(F)c1cc2cc(c1)Nc1nc(nc(-c3cccc(C(F)(F)F)n3)n1)NCCCCCC2 | Homo sapiens | CHEMBL4708483 | single protein format |
| CHEMBL4278845 |  |
IC50 | = | 7.0 | nM | 414.74 | C[C@H](Nc1nc(N[C@@H](C)C(F)(F)F)nc(-c2cccc(Cl)n2)n1)C(F)(F)F | Homo sapiens | CHEMBL4338886 | cell-based format |
| CHEMBL5405494 |  |
IC50 | = | 7.0 | nM | 488.39 | OCC(O)CNc1nc(Nc2cccc(C(F)(F)F)c2)nc(Nc2cccc(C(F)(F)F)c2)n1 | Homo sapiens | CHEMBL5368521 | single protein format |
| CHEMBL5428697 |  |
IC50 | = | 8.0 | nM | 488.39 | OCC(CO)Nc1nc(Nc2cccc(C(F)(F)F)c2)nc(Nc2cccc(C(F)(F)F)c2)n1 | Homo sapiens | CHEMBL5368521 | single protein format |
| CHEMBL4283785 |  |
IC50 | = | 8.0 | nM | 414.74 | CC(Nc1nc(NC(C)C(F)(F)F)nc(-c2cccc(Cl)n2)n1)C(F)(F)F | Homo sapiens | CHEMBL4338886 | cell-based format |
| CHEMBL4277352 |  |
IC50 | = | 9.0 | nM | 464.39 | FC1(F)CCC(Nc2nc(NC3CCC(F)(F)C3)nc(-c3cccc(C(F)(F)F)n3)n2)C1 | Homo sapiens | CHEMBL4338886 | cell-based format |
| CHEMBL5430339 |  |
IC50 | = | 9.0 | nM | 488.39 | OC[C@@H](O)CNc1nc(Nc2cccc(C(F)(F)F)c2)nc(Nc2cccc(C(F)(F)F)c2)n1 | Homo sapiens | CHEMBL5368521 | single protein format |
| CHEMBL4800354 |  |
IC50 | = | 12.2 | nM | 464.88 | FC(F)(F)c1cccc(-c2nc3nc(n2)Nc2cc(Cl)cc(c2)CCCCOCCN3)n1 | Homo sapiens | CHEMBL4708483 | single protein format |
| CHEMBL4292293 |  |
IC50 | = | 13.0 | nM | 364.38 | FC(F)(F)c1cccc(-c2nc(NCC3CC3)nc(NCC3CC3)n2)n1 | Homo sapiens | CHEMBL4338883 | cell-based format |
| CHEMBL4796025 |  |
IC50 | = | 13.8 | nM | 480.42 | FC(F)(F)c1cc2cc(c1)Nc1nc(nc(-c3cccc(C(F)(F)F)n3)n1)NCCC/C=C/C2 | Homo sapiens | CHEMBL4708483 | single protein format |
| CHEMBL4282989 |  |
IC50 | = | 14.0 | nM | 386.93 | CCC(Nc1nc(NC(CC)C2CC2)nc(-c2cccc(Cl)n2)n1)C1CC1 | Homo sapiens | CHEMBL4338886 | cell-based format |
| CHEMBL4280772 |  |
IC50 | = | 16.0 | nM | 436.34 | FC1(F)CC(Nc2nc(NC3CC(F)(F)C3)nc(-c3cccc(C(F)(F)F)n3)n2)C1 | Homo sapiens | CHEMBL4338883 | cell-based format |
| CHEMBL4786020 |  |
IC50 | = | 17.4 | nM | 496.42 | FC(F)(F)c1cc2cc(c1)OC/C=C\CCCNc1nc(nc(-c3cccc(C(F)(F)F)n3)n1)N2 | Homo sapiens | CHEMBL4708483 | single protein format |
| CHEMBL4753744 |  |
IC50 | = | 18.4 | nM | 482.39 | FC(F)(F)c1cc2cc(c1)OC/C=C\CCNc1nc(nc(-c3cccc(C(F)(F)F)n3)n1)N2 | Homo sapiens | CHEMBL4708483 | single protein format |
| CHEMBL4783076 |  |
IC50 | = | 18.6 | nM | 448.42 | Fc1cc2cc(c1)Nc1nc(nc(-c3cccc(C(F)(F)F)n3)n1)NCCOCCCC2 | Homo sapiens | CHEMBL4708483 | single protein format |