P48729 | KC1A_HUMAN | Casein kinase I isoform alpha (CSNK1A1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 17~236 |
3D structures mapped by conservation among orthologs
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL535 |  |
IC50 | < | 1.0 | nM | 398.48 | CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C | Homo sapiens | CHEMBL1244314 | single protein format |
| CHEMBL5416410 |  |
IC50 | < | 1.0 | nM | 506.03 | Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1.O | Homo sapiens | CHEMBL1244314 | single protein format |
| CHEMBL4754493 |  |
IC50 | = | 5.3 | nM | 360.89 | Cn1ncc(-c2nc(N[C@H]3CC[C@H](N)CC3)ncc2Cl)c1CC1CC1 | Homo sapiens | CHEMBL5123392 | single protein format |
| CHEMBL5303449 |  |
IC50 | = | 7.2 | nM | 408.46 | CN1CCC(F)(Cn2cnc(-c3ccc(F)cn3)c2-c2ccnc3[nH]ccc23)CC1 | Homo sapiens | CHEMBL5446200 | single protein format |
| CHEMBL2203552 |  |
IC50 | = | 9.0 | nM | 371.4 | COc1cnc(-c2cnc3ccccc3c2)nc1-c1cc2c([nH]1)CCNC2=O | Homo sapiens | CHEMBL2211469 | single protein format |
| CHEMBL215919 |  |
IC50 | = | 14.0 | nM | 417.52 | CC[C@H](CO)Nc1nc(Nc2cccc(-c3ccccn3)c2)c2ncn(C(C)C)c2n1 | Homo sapiens | CHEMBL2091519 | single protein format |
| CHEMBL1080583 |  |
IC50 | = | 14.0 | nM | 417.52 | CCC(CO)Nc1nc(Nc2cccc(-c3ccccn3)c2)c2ncn(C(C)C)c2n1 | Homo sapiens | CHEMBL1114223 | single protein format |
| CHEMBL2203555 |  |
IC50 | = | 19.0 | nM | 349.39 | COc1cnc(NCc2ccccc2)nc1-c1cc2c([nH]1)CCNC2=O | Homo sapiens | CHEMBL2211469 | single protein format |
| CHEMBL2203553 |  |
IC50 | = | 33.0 | nM | 364.38 | COc1cnc(/C=C/c2ccc(F)cc2)nc1-c1cc2c([nH]1)CCNC2=O | Homo sapiens | CHEMBL2211469 | single protein format |
| CHEMBL2010872 |  |
IC50 | = | 48.0 | nM | 477.57 | CC(C)Cn1c2ccc(Nc3ncccn3)cc2c2c3c(c4c(c21)CCc1nn(C)cc1-4)C(=O)NC3 | Homo sapiens | CHEMBL2016108 | single protein format |
| CHEMBL2203556 |  |
IC50 | = | 54.0 | nM | 335.37 | COc1cnc(Nc2ccccc2)nc1-c1cc2c([nH]1)CCNC2=O | Homo sapiens | CHEMBL2211469 | single protein format |
| CHEMBL2089212 |  |
IC50 | = | 78.0 | nM | 412.82 | Nc1n[nH]c2nc(Nc3cccc(NC(=O)Nc4ccc(F)c(Cl)c4)c3)ncc12 | Homo sapiens | CHEMBL2091519 | single protein format |
| CHEMBL2203557 |  |
IC50 | = | 95.0 | nM | 368.37 | COc1cnc(OCc2ccc(F)cc2)nc1-c1cc2c([nH]1)CCNC2=O | Homo sapiens | CHEMBL2211469 | single protein format |
| CHEMBL2089214 |  |
IC50 | = | 142.0 | nM | 406.45 | CC(C)(C)c1cc(NC(=O)Nc2cccc(Nc3ncc4c(N)n[nH]c4n3)c2)n[nH]1 | Homo sapiens | CHEMBL2091519 | single protein format |
| CHEMBL2203559 |  |
IC50 | = | 146.0 | nM | 368.37 | COc1cnc(COc2ccc(F)cc2)nc1-c1cc2c([nH]1)CCNC2=O | Homo sapiens | CHEMBL2211469 | single protein format |
| CHEMBL2089036 |  |
IC50 | = | 150.0 | nM | 569.11 | CC(C)[C@H](N)C(=O)OC[C@H](O)CNc1nc(NCc2ccc(-c3ccccn3)cc2)c2ncn(C(C)C)c2n1.Cl | Homo sapiens | CHEMBL2089673 | single protein format |
| CHEMBL2203561 |  |
IC50 | = | 174.0 | nM | 367.38 | COc1cnc(COc2ccc(F)cc2)cc1-c1cc2c([nH]1)CCNC2=O | Homo sapiens | CHEMBL2211469 | single protein format |
| CHEMBL2089032 |  |
IC50 | = | 180.0 | nM | 433.52 | CC(C)n1cnc2c(NCc3ccc(-c4ccccn4)cc3)nc(NC[C@@H](O)CO)nc21 | Homo sapiens | CHEMBL2089673 | single protein format |
| CHEMBL5186013 |  |
IC50 | = | 220.0 | nM | 330.14 | Nc1nc2ccc(Br)cc2c2nc(-c3ccco3)nn12 | Homo sapiens | CHEMBL5100012 | single protein format |
| CHEMBL2203562 |  |
IC50 | = | 225.0 | nM | 385.37 | COc1cnc(COc2ccc(F)cc2F)cc1-c1cc2c([nH]1)CCNC2=O | Homo sapiens | CHEMBL2211469 | single protein format |