P48546 | GIPR_HUMAN | Gastric inhibitory polypeptide receptor (GIPR)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00002 | 7tm_2 - 7 transmembrane receptor (Secretin family) | 135~388 | |
| PF02793 | HRM - Hormone receptor domain | 59~120 |
3D structures mapped by conservation among orthologs
[ Domain: "Hormone receptor domain (HRM, Pfam 02793)" // HRM ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL198736 |  |
IC50 | = | 28.3 | nM | 563.62 | CC(C)(C)C1CCC(N(Cc2ccc(C(=O)NCCC(=O)O)cc2)C(=O)Nc2ccc(OC(F)(F)F)cc2)CC1 | Homo sapiens | CHEMBL977342 | cell-based format |
| CHEMBL219384 |  |
IC50 | = | 38.0 | nM | 557.57 | CC(C)(C)c1ccc(N(Cc2ccc(C(=O)NCCC(=O)O)cc2)C(=O)Nc2ccc(OC(F)(F)F)cc2)cc1 | Homo sapiens | CHEMBL977342 | cell-based format |
| CHEMBL386446 |  |
IC50 | = | 64.0 | nM | 566.49 | O=C(O)CCNC(=O)c1ccc(CN(C(=O)Nc2cc(Cl)cc(Cl)c2)c2ccc(C3=CCCCC3)cc2)cc1 | Homo sapiens | CHEMBL977342 | cell-based format |
| CHEMBL447742 |  |
IC50 | = | 74.0 | nM | 571.72 | CC(C)(C)c1cccc(NC(=O)N(Cc2ccc(C(=O)NC[C@@H](O)C(=O)O)cc2)c2ccc(C3CCCCC3)cc2)c1 | Homo sapiens | CHEMBL977342 | cell-based format |
| CHEMBL487668 |  |
IC50 | = | 93.0 | nM | 584.5 | O=C(NC[C@@H](O)C(=O)O)c1ccc(CN(C(=O)Nc2cc(Cl)cc(Cl)c2)c2ccc(C3CCCCC3)cc2)cc1 | Homo sapiens | CHEMBL977342 | cell-based format |
| CHEMBL486651 |  |
IC50 | = | 98.0 | nM | 577.64 | Cc1cc(NC(=O)N(Cc2ccc(C(=O)NC[C@@H](O)C(=O)O)cc2)[C@H]2CC[C@H](C(C)(C)C)CC2)cc(C(F)(F)F)c1 | Homo sapiens | CHEMBL977342 | cell-based format |
| CHEMBL452311 |  |
IC50 | = | 216.0 | nM | 594.51 | O=C(NC[C@@H](O)C(=O)O)c1ccc(CN(C(=O)Nc2cccc(Br)c2)c2ccc(C3CCCCC3)cc2)cc1 | Homo sapiens | CHEMBL977342 | cell-based format |
| CHEMBL452067 |  |
IC50 | = | 220.0 | nM | 523.67 | Cc1cc(C)cc(NC(=O)N(Cc2ccc(C(=O)NC[C@@H](O)C(=O)O)cc2)[C@H]2CC[C@H](C(C)(C)C)CC2)c1 | Homo sapiens | CHEMBL977342 | cell-based format |
| CHEMBL447684 |  |
IC50 | = | 277.0 | nM | 599.58 | O=C(NC[C@@H](O)C(=O)O)c1ccc(CN(C(=O)Nc2cc(F)cc(C(F)(F)F)c2)c2ccc(C3=CCCCC3)cc2)cc1 | Homo sapiens | CHEMBL977342 | cell-based format |
| CHEMBL486650 |  |
IC50 | = | 315.0 | nM | 573.57 | CC(C)(C)c1ccc(N(Cc2ccc(C(=O)NCC(O)C(=O)O)cc2)C(=O)Nc2ccc(OC(F)(F)F)cc2)cc1 | Homo sapiens | CHEMBL977342 | cell-based format |
| CHEMBL493020 |  |
IC50 | = | 316.0 | nM | 575.01 | O=C(O)CCNC(=O)c1ccc(CC(c2ccc(OC(F)(F)F)cc2)c2nc(-c3ccc(Cl)cc3)cs2)cc1 | Homo sapiens | CHEMBL973452 | cell-based format |
| CHEMBL487476 |  |
IC50 | = | 359.0 | nM | 582.48 | O=C(NC[C@@H](O)C(=O)O)c1ccc(CN(C(=O)Nc2cc(Cl)cc(Cl)c2)c2ccc(C3=CCCCC3)cc2)cc1 | Homo sapiens | CHEMBL977342 | cell-based format |
| CHEMBL491920 |  |
IC50 | = | 381.0 | nM | 559.01 | O=C(O)CCNC(=O)c1ccc(CC(c2ccc(Cl)cc2)c2nc(-c3ccc(C(F)(F)F)cc3)cs2)cc1 | Homo sapiens | CHEMBL973452 | cell-based format |
| CHEMBL521650 |  |
IC50 | = | 389.0 | nM | 537.69 | O=C(O)CCNC(=O)c1ccc(CN(c2ccc(C3=CCCCC3)cc2)c2nc(-c3ccccc3)cs2)cc1 | Homo sapiens | CHEMBL973452 | cell-based format |
| CHEMBL520893 |  |
IC50 | = | 406.0 | nM | 548.04 | O=C(NC[C@@H](O)C(=O)O)c1ccc(CN(C(=O)Nc2cccc(Cl)c2)c2ccc(C3=CCCCC3)cc2)cc1 | Homo sapiens | CHEMBL977342 | cell-based format |
| CHEMBL528775 |  |
IC50 | = | 411.0 | nM | 561.7 | CSc1cccc(NC(=O)N(Cc2ccc(C(=O)NC[C@@H](O)C(=O)O)cc2)c2ccc(C3CCCCC3)cc2)c1 | Homo sapiens | CHEMBL977342 | cell-based format |
| CHEMBL493019 |  |
IC50 | = | 429.0 | nM | 575.01 | O=C(O)CCNC(=O)c1ccc(CC(c2ccc(Cl)cc2)c2nc(-c3ccc(OC(F)(F)F)cc3)cs2)cc1 | Homo sapiens | CHEMBL973452 | cell-based format |
| CHEMBL519903 |  |
IC50 | = | 445.0 | nM | 582.48 | O=C(NC[C@H](O)C(=O)O)c1ccc(CN(C(=O)Nc2cc(Cl)cc(Cl)c2)c2ccc(C3=CCCCC3)cc2)cc1 | Homo sapiens | CHEMBL977342 | cell-based format |
| CHEMBL492605 |  |
IC50 | = | 510.0 | nM | 565.62 | O=C(O)CCNC(=O)c1ccc(CN(c2ccc3c(c2)CCC3)c2nc(-c3ccc(C(F)(F)F)cc3)cs2)cc1 | Homo sapiens | CHEMBL995931 | cell-based format |
| CHEMBL448561 |  |
IC50 | = | 555.0 | nM | 580.11 | O=C(O)CCNC(=O)c1ccc(N(Cc2ccc3c(c2)Cc2ccccc2-3)c2nc(-c3ccc(Cl)cc3)cs2)cc1 | Homo sapiens | CHEMBL973452 | cell-based format |