P48449 | LSS_HUMAN | Lanosterol synthase (LSS)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF13243 | SQHop_cyclase_C - Squalene-hopene cyclase C-terminal domain | 384~720 | |
| PF13249 | SQHop_cyclase_N - Squalene-hopene cyclase N-terminal domain | 84~325 |
3D structures mapped by conservation among orthologs
[ Domain: "alpha/alpha toroid" // SQHop_cyclase_C ]
[ Domain: "alpha/alpha toroid" // SQHop_cyclase_N ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL64905 |  |
IC50 | = | 0.22 | nM | 446.79 | CC(C)=CCCC(C)SCC/C(C)=C/CC/C=C(\C)CC/C=C(\C)CCC1OC1(C)C | Homo sapiens | CHEMBL758669 | single protein format |
| CHEMBL542453 |  |
IC50 | = | 1.9 | nM | 432.95 | C=CCN(C)CCCCCCOc1ccc(C(=O)c2ccc([N+](=O)[O-])cc2)cc1.Cl | Homo sapiens | CHEMBL615200 | single protein format |
| CHEMBL63335 |  |
IC50 | = | 2.3 | nM | 432.76 | CC(C)=CCCSCCC/C(C)=C/CC/C=C(\C)CC/C=C(\C)CCC1OC1(C)C | Homo sapiens | CHEMBL758669 | single protein format |
| CHEMBL67133 |  |
IC50 | = | 2.9 | nM | 459.45 | C=CCN(C)CCCCCCOc1ccc2c(-c3ccc(Br)cc3)nsc2c1 | Homo sapiens | CHEMBL754981 | tissue-based format |
| CHEMBL112210 |  |
IC50 | = | 2.9 | nM | 575.53 | C=CCN(C)CCCCCCOc1ccc2c(-c3ccc(Br)cc3)nsc2c1.O=C(O)/C=C/C(=O)O | Homo sapiens | CHEMBL615201 | single protein format |
| CHEMBL63524 |  |
IC50 | = | 3.0 | nM | 400.32 | C=CCN(C)C/C=C/COc1ccc(C(=O)c2ccc(Br)cc2)cc1 | Homo sapiens | CHEMBL754981 | tissue-based format |
| CHEMBL482527 |  |
IC50 | = | 3.0 | nM | 391.9 | O=C(c1ccc(Cl)cc1)N1CCN(Cc2ccc(-c3ccncc3)cc2)CC1 | Homo sapiens | CHEMBL956674 | single protein format |
| CHEMBL543877 |  |
IC50 | = | 3.5 | nM | 489.89 | C=CCN(C)CCCCCCOc1ccc2c(-c3ccc(Br)cc3)nccc2c1.Cl | Homo sapiens | CHEMBL615201 | single protein format |
| CHEMBL65024 |  |
IC50 | = | 3.5 | nM | 453.42 | C=CCN(C)CCCCCCOc1ccc2c(-c3ccc(Br)cc3)nccc2c1 | Homo sapiens | CHEMBL754981 | tissue-based format |
| CHEMBL116705 |  |
IC50 | = | 4.1 | nM | 575.5 | C=CCN(C)CCCCCCOc1ccc(C(=O)c2ccc(Br)cc2)c(NC)c1.O=C(O)/C=C/C(=O)O | Homo sapiens | CHEMBL615201 | single protein format |
| CHEMBL115085 |  |
IC50 | = | 4.1 | nM | 573.48 | C=CCN(C)CCCCCCOc1ccc2c(c1)CON=C2c1ccc(Br)cc1.O=C(O)/C=C/C(=O)O | Homo sapiens | CHEMBL615201 | single protein format |
| CHEMBL66638 |  |
IC50 | = | 4.1 | nM | 457.41 | C=CCN(C)CCCCCCOc1ccc2c(c1)CON=C2c1ccc(Br)cc1 | Homo sapiens | CHEMBL754981 | tissue-based format |
| CHEMBL115020 |  |
IC50 | = | 4.6 | nM | 576.48 | C=CCN(C)CCCCCCOc1ccc(C(=O)c2ccc(Br)cc2)c(OC)c1.O=C(O)/C=C/C(=O)O | Homo sapiens | CHEMBL615201 | single protein format |
| CHEMBL135109 |  |
IC50 | = | 4.6 | nM | 520.0 | C=CCN(C)CCCCCCOc1ccc(C(=O)c2ccc(Cl)cc2)c(F)c1.O=C(O)/C=C/C(=O)O | Homo sapiens | CHEMBL758670 | single protein format |
| CHEMBL416694 |  |
IC50 | = | 5.4 | nM | 430.39 | C=CCN(C)CCCCCCOc1ccc(C(=O)c2ccc(Br)cc2)cc1 | Homo sapiens | CHEMBL754981 | tissue-based format |
| CHEMBL114259 |  |
IC50 | = | 5.4 | nM | 546.46 | C=CCN(C)CCCCCCOc1ccc(C(=O)c2ccc(Br)cc2)cc1.O=C(O)/C=C/C(=O)O | Homo sapiens | CHEMBL615201 | single protein format |
| CHEMBL116000 |  |
IC50 | = | 5.6 | nM | 574.54 | C=CCN(C)CCCCCCOc1ccc2c(-c3ccc(Br)cc3)csc2c1.O=C(O)/C=C/C(=O)O | Homo sapiens | CHEMBL615201 | single protein format |
| CHEMBL484125 |  |
IC50 | = | 6.0 | nM | 449.02 | CN1CCN(c2ccc(CN3CCN(S(=O)(=O)c4ccc(Cl)cc4)CC3)cc2)CC1 | Homo sapiens | CHEMBL956674 | single protein format |
| CHEMBL115923 |  |
IC50 | = | 6.2 | nM | 592.55 | C=CCN(C)CCCCCCOc1ccc(C(=O)c2ccc(Br)cc2)c(SC)c1.O=C(O)/C=C/C(=O)O | Homo sapiens | CHEMBL615201 | single protein format |
| CHEMBL115375 |  |
IC50 | = | 6.3 | nM | 562.46 | C=CCN(C)CCCCCCOc1ccc(C(=O)c2ccc(Br)cc2)c(O)c1.O=C(O)/C=C/C(=O)O | Homo sapiens | CHEMBL615201 | single protein format |