P48443 | RXRG_HUMAN | Retinoic acid receptor RXR-gamma (RXRG)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00104 | Hormone_recep - Ligand-binding domain of nuclear hormone receptor | 258~442 | |
| PF00105 | zf-C4 - Double treble clef zinc finger, C4 type | 138~206 | |
| PF11825 | Nuc_recep-AF1 - Nuclear/hormone receptor activator site AF-1 | 25~134 |
3D structures mapped by conservation among orthologs
[ Domain: "Nuclear receptor ligand-binding domain" // Hormone_recep ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL705 |  |
IC50 | = | 4.0 | nM | 300.44 | CC1=C(/C=C/C(C)=C\C=C\C(C)=C\C(=O)O)C(C)(C)CCC1 | Homo sapiens | CHEMBL800767 | single protein format |
| CHEMBL424636 |  |
IC50 | = | 10.0 | nM | 390.57 | C/C(=C\c1ccc(C(=O)O)cc1)c1cc2c(cc1C(C)C)C(C)(C)CCC2(C)C | Homo sapiens | CHEMBL800767 | single protein format |
| CHEMBL284937 |  |
IC50 | = | 10.0 | nM | 376.54 | CCc1cc2c(cc1/C(C)=C/c1ccc(C(=O)O)cc1)C(C)(C)CCC2(C)C | Homo sapiens | CHEMBL800767 | single protein format |
| CHEMBL32505 |  |
IC50 | = | 100.0 | nM | 362.51 | C/C(=C\c1ccc(C(=O)O)cc1)c1cc2c(cc1C)C(C)(C)CCC2(C)C | Homo sapiens | CHEMBL800767 | single protein format |
| CHEMBL38 |  |
IC50 | = | 350.0 | nM | 300.44 | CC1=C(/C=C/C(C)=C/C=C/C(C)=C/C(=O)O)C(C)(C)CCC1 | Homo sapiens | CHEMBL800767 | single protein format |
| CHEMBL38 | |
Ki | = | 1.4 | nM | 300.44 | CC1=C(/C=C/C(C)=C/C=C/C(C)=C/C(=O)O)C(C)(C)CCC1 | Homo sapiens | CHEMBL681085 | single protein format |
| CHEMBL337393 |  |
Ki | = | 2.8 | nM | 462.48 | C/C(=C/C=C/C(C)=C/C(=O)O)c1cc(-c2cc(F)cc(F)c2)cc(C(C)C)c1OCC(F)F | Homo sapiens | CHEMBL806019 | cell-based format |
| CHEMBL130232 |  |
Ki | = | 2.9 | nM | 444.49 | C/C(=C/C=C/C(C)=C/C(=O)O)c1cc(-c2cccc(F)c2)cc(C(C)C)c1OCC(F)F | Homo sapiens | CHEMBL806019 | cell-based format |
| CHEMBL111589 |  |
Ki | = | 4.0 | nM | 368.52 | COc1cc2c(cc1/C(C)=C\C=C\C(C)=C\C(=O)O)C(C)(C)CCC2(C)C | Homo sapiens | CHEMBL798966 | single protein format |
| CHEMBL162334 |  |
Ki | = | 5.0 | nM | 365.47 | Cc1cc2c(cc1/C(=N/O)c1ccc(C(=O)O)cc1)C(C)(C)CCC2(C)C | Homo sapiens | CHEMBL803362 | single protein format |
| CHEMBL92284 |  |
Ki | = | 5.0 | nM | 352.52 | CC(/C=C/C1(c2cc3c(cc2C)C(C)(C)CCC3(C)C)CC1)=C\C(=O)O | Homo sapiens | CHEMBL800769 | single protein format |
| CHEMBL130374 |  |
Ki | = | 5.6 | nM | 432.53 | C/C(=C/C=C/C(C)=C/C(=O)O)c1cc(-c2cccs2)cc(C(C)C)c1OCC(F)F | Homo sapiens | CHEMBL806019 | cell-based format |
| CHEMBL133915 |  |
Ki | = | 5.6 | nM | 444.49 | C/C(=C/C=C/C(C)=C/C(=O)O)c1cc(-c2ccc(F)cc2)cc(C(C)C)c1OCC(F)F | Homo sapiens | CHEMBL806019 | cell-based format |
| CHEMBL93518 |  |
Ki | = | 6.0 | nM | 338.49 | CC(/C=C/C1(c2ccc3c(c2)C(C)(C)CCC3(C)C)CC1)=C\C(=O)O | Homo sapiens | CHEMBL800769 | single protein format |
| CHEMBL133896 |  |
Ki | = | 7.7 | nM | 432.43 | CCOc1c(/C(C)=C\C=C\C(C)=C\C(=O)O)cc(C(F)(F)C(F)(F)F)cc1C(C)C | Homo sapiens | CHEMBL806019 | cell-based format |
| CHEMBL423465 |  |
Ki | = | 8.0 | nM | 379.5 | CO/N=C(\c1ccc(C(=O)O)cc1)c1cc2c(cc1C)C(C)(C)CCC2(C)C | Homo sapiens | CHEMBL803362 | single protein format |
| CHEMBL89241 |  |
Ki | = | 9.3 | nM | 340.51 | CC(/C=C/C=C(\C)c1cc(C(C)(C)C)cc(C(C)(C)C)c1)=C\C(=O)O | Homo sapiens | CHEMBL803363 | single protein format |
| CHEMBL208316 |  |
Ki | = | 10.0 | nM | 383.58 | CCCN(C/C=C/C(C)=C/C(=O)O)c1cc(C(C)(C)C)cc2c1CCC2(C)C | Homo sapiens | CHEMBL865142 | single protein format |
| CHEMBL422088 |  |
Ki | = | 10.9 | nM | 444.49 | C/C(=C/C=C/C(C)=C/C(=O)O)c1cc(-c2ccccc2F)cc(C(C)C)c1OCC(F)F | Homo sapiens | CHEMBL806019 | cell-based format |
| CHEMBL41890 |  |
Ki | = | 12.0 | nM | 422.59 | CCOc1c(-c2cccc3sc(/C(C)=C/C(=O)O)cc23)cc(C(C)C)cc1C(C)C | Homo sapiens | CHEMBL799931 | single protein format |