P48426 | PI42A_HUMAN | Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (PIP4K2A)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF01504 | PIP5K - Phosphatidylinositol-4-phosphate 5-Kinase | 125~403 |
3D structures mapped by conservation among orthologs
[ Domain: "SAICAR synthase" // PIP5K ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4802045 |  |
IC50 | = | 1.3 | nM | 440.48 | CC[C@@H](Nc1c(C#N)c(-c2ccc(-c3cccc(C)c3F)cc2)nc2cnccc12)C(=O)O | Homo sapiens | CHEMBL4887755 | single protein format |
| CHEMBL5280127 |  |
IC50 | = | 2.0 | nM | 460.9 | CC[C@@H](Nc1c(C#N)c(-c2ccc(-c3cccc(Cl)c3F)cc2)nc2cnccc12)C(=O)O | Homo sapiens | CHEMBL5243014 | cell-based format |
| CHEMBL5276719 |  |
IC50 | = | 5.0 | nM | 452.51 | CCOc1ccccc1-c1ccc(-c2nc3cnccc3c(N[C@H](CC)C(=O)O)c2C#N)cc1 | Homo sapiens | CHEMBL5243014 | cell-based format |
| CHEMBL5270765 |  |
IC50 | = | 7.0 | nM | 485.98 | CCOc1ccccc1-c1ccc(-c2nc3cncc(Cl)c3c(N[C@H](CC)C(N)=O)c2C#N)cc1 | Homo sapiens | CHEMBL5243014 | cell-based format |
| CHEMBL5290005 |  |
IC50 | = | 13.0 | nM | 459.91 | CC[C@@H](Nc1c(C#N)c(-c2ccc(-c3cccc(Cl)c3F)cc2)nc2cnccc12)C(N)=O | Homo sapiens | CHEMBL5243014 | cell-based format |
| CHEMBL5271652 |  |
IC50 | = | 14.0 | nM | 438.49 | CCOc1ccccc1-c1ccc(-c2nc3cnccc3c(NC(C)C(=O)O)c2C#N)cc1 | Homo sapiens | CHEMBL5243014 | cell-based format |
| CHEMBL5277824 |  |
IC50 | = | 19.0 | nM | 439.49 | CC[C@@H](Nc1c(C#N)c(-c2ccc(-c3cccc(C)c3F)cc2)nc2cnccc12)C(N)=O | Homo sapiens | CHEMBL5243014 | cell-based format |
| CHEMBL5288492 |  |
IC50 | = | 30.0 | nM | 555.66 | CCOc1ccccc1-c1ccc(-c2nc3cnccc3c(N[C@H](CC)C(=O)NS(=O)(=O)C3CC3)c2C#N)cc1 | Homo sapiens | CHEMBL5243014 | cell-based format |
| CHEMBL5282226 |  |
IC50 | = | 37.0 | nM | 425.47 | CC[C@@H](Nc1c(C#N)c(-c2ccc(-c3ccccc3F)cc2)nc2cnccc12)C(N)=O | Homo sapiens | CHEMBL5243014 | cell-based format |
| CHEMBL5284796 |  |
IC50 | = | 40.0 | nM | 529.62 | CCOc1ccccc1-c1ccc(-c2nc3cnccc3c(N[C@H](CC)C(=O)NS(C)(=O)=O)c2C#N)cc1 | Homo sapiens | CHEMBL5243014 | cell-based format |
| CHEMBL5271804 |  |
IC50 | = | 40.0 | nM | 490.44 | CN1C(=O)[C@@H](CC2CCCC2)N(C2CCCC2)c2nc(Nc3cc(Cl)c(O)c(Cl)c3)ncc21 | Homo sapiens | CHEMBL5260671 | single protein format |
| CHEMBL5273876 |  |
IC50 | = | 42.0 | nM | 437.5 | CC[C@@H](Nc1c(C#N)c(-c2ccc(-c3ccccc3OC)cc2)nc2cnccc12)C(N)=O | Homo sapiens | CHEMBL5243014 | cell-based format |
| CHEMBL5272762 |  |
IC50 | = | 47.0 | nM | 455.49 | CC[C@@H](Nc1c(C#N)c(-c2ccc(-c3ccc(F)cc3OC)cc2)nc2cnccc12)C(N)=O | Homo sapiens | CHEMBL5243014 | cell-based format |
| CHEMBL5265849 |  |
IC50 | = | 61.0 | nM | 421.5 | CC[C@@H](Nc1c(C#N)c(-c2ccc(-c3cccc(C)c3)cc2)nc2cnccc12)C(N)=O | Homo sapiens | CHEMBL5243014 | cell-based format |
| CHEMBL5274835 |  |
IC50 | = | 66.0 | nM | 411.26 | CC[C@@H](Nc1c(C#N)c(-c2ccc(Br)cc2)nc2cnccc12)C(=O)O | Homo sapiens | CHEMBL5243014 | cell-based format |
| CHEMBL5275703 |  |
IC50 | = | 74.0 | nM | 441.92 | CC[C@@H](Nc1c(C#N)c(-c2ccc(-c3cccc(Cl)c3)cc2)nc2cnccc12)C(N)=O | Homo sapiens | CHEMBL5243014 | cell-based format |
| CHEMBL5288989 |  |
IC50 | = | 88.0 | nM | 425.47 | CC[C@@H](Nc1c(C#N)c(-c2ccc(-c3ccc(F)cc3)cc2)nc2cnccc12)C(N)=O | Homo sapiens | CHEMBL5243014 | cell-based format |
| CHEMBL5273777 |  |
IC50 | = | 89.0 | nM | 451.53 | CCOc1ccccc1-c1ccc(-c2nc3cnccc3c(N[C@H](CC)C(N)=O)c2C#N)cc1 | Homo sapiens | CHEMBL5243014 | cell-based format |
| CHEMBL5286700 |  |
IC50 | = | 110.0 | nM | 421.5 | CC[C@@H](Nc1c(C#N)c(-c2ccc(-c3ccccc3C)cc2)nc2cnccc12)C(N)=O | Homo sapiens | CHEMBL5243014 | cell-based format |
| CHEMBL4447308 |  |
IC50 | = | 130.0 | nM | 375.43 | CS(=O)(=O)Nc1ccc(-c2cncc(/C=C3\SC(=O)NC3=O)c2)cc1 | Homo sapiens | CHEMBL4406333 | single protein format |