P48163 | MAOX_HUMAN | NADP-dependent malic enzyme (ME1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00390 | malic - Malic enzyme, N-terminal domain | 79~260 | |
| PF03949 | Malic_M - Malic enzyme, NAD binding domain | 270~522 |
3D structures mapped by conservation among orthologs
[ Domain: "C-terminal domain of Malic enzyme" // Malic_M ]
[ Domain: "NAD(P)-binding Rossmann-fold domains" // Malic_M ]
[ Domain: "Aminoacid dehydrogenase-like, N-terminal domain" // malic ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL372408 |  |
IC50 | = | 150.0 | nM | 351.41 | O=C1CC(N2CCN(c3ccc(O)cc3)CC2)C(=O)N1c1ccccc1 | Homo sapiens | CHEMBL859587 | single protein format |
| CHEMBL5279096 |  |
IC50 | = | 150.0 | nM | 330.82 | O=C(Cc1ccc(Cl)cc1)N1CCN(c2ccc(O)cc2)CC1 | Homo sapiens | CHEMBL5225649 | single protein format |
| CHEMBL5277536 |  |
IC50 | = | 150.0 | nM | 338.45 | CC(C)(CC(=O)N1CCN(c2ccc(O)cc2)CC1)c1ccccc1 | Homo sapiens | CHEMBL5225649 | single protein format |
| CHEMBL5275653 |  |
IC50 | = | 170.0 | nM | 308.38 | O=C(/C=C/c1ccccc1)N1CCN(c2ccc(O)cc2)CC1 | Homo sapiens | CHEMBL5225649 | single protein format |
| CHEMBL5284469 |  |
IC50 | = | 180.0 | nM | 296.37 | O=C(Cc1ccccc1)N1CCN(c2ccc(O)cc2)CC1 | Homo sapiens | CHEMBL5225649 | single protein format |
| CHEMBL5287773 |  |
IC50 | = | 180.0 | nM | 314.36 | O=C(Cc1ccc(F)cc1)N1CCN(c2ccc(O)cc2)CC1 | Homo sapiens | CHEMBL5225649 | single protein format |
| CHEMBL5278951 |  |
IC50 | = | 200.0 | nM | 297.36 | O=C(Nc1ccccc1)N1CCN(c2ccc(O)cc2)CC1 | Homo sapiens | CHEMBL5225649 | single protein format |
| CHEMBL5283020 |  |
IC50 | = | 210.0 | nM | 364.37 | O=C(Cc1ccc(C(F)(F)F)cc1)N1CCN(c2ccc(O)cc2)CC1 | Homo sapiens | CHEMBL5225649 | single protein format |
| CHEMBL5267207 |  |
IC50 | = | 220.0 | nM | 295.3 | O=C(Nc1nnn[nH]1)C1c2ccccc2OC2C=CC=CC21 | Homo sapiens | CHEMBL5225649 | single protein format |
| CHEMBL5289840 |  |
IC50 | = | 270.0 | nM | 310.4 | O=C(CCc1ccccc1)N1CCN(c2ccc(O)cc2)CC1 | Homo sapiens | CHEMBL5225649 | single protein format |
| CHEMBL5289950 |  |
IC50 | = | 340.0 | nM | 311.39 | O=C(CN1CCN(c2ccc(O)cc2)CC1)Nc1ccccc1 | Homo sapiens | CHEMBL5225649 | single protein format |
| CHEMBL5284610 |  |
IC50 | = | 420.0 | nM | 382.5 | CCCCOc1ccc(CCC(=O)N2CCN(c3ccc(O)cc3)CC2)cc1 | Homo sapiens | CHEMBL5225649 | single protein format |
| CHEMBL201911 |  |
IC50 | = | 450.0 | nM | 365.43 | O=C1CC(N2CCN(c3ccc(O)cc3)CC2)C(=O)N1Cc1ccccc1 | Homo sapiens | CHEMBL859587 | single protein format |
| CHEMBL202332 |  |
IC50 | = | 560.0 | nM | 399.88 | Cc1ccc(N2C(=O)CC(N3CCN(c4ccc(O)cc4)CC3)C2=O)cc1Cl | Homo sapiens | CHEMBL859587 | single protein format |
| CHEMBL5279230 |  |
IC50 | = | 630.0 | nM | 312.37 | O=C(COc1ccccc1)N1CCN(c2ccc(O)cc2)CC1 | Homo sapiens | CHEMBL5225649 | single protein format |
| CHEMBL5218866 |  |
IC50 | = | 940.0 | nM | 352.34 | COc1ccc(C2=C(O)C(=O)C(c3ccc(OC)cc3)=C(O)C2=O)cc1 | Homo sapiens | CHEMBL5225649 | single protein format |