P48145 | NPBW1_HUMAN | Neuropeptides B/W receptor type 1 (NPBWR1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00001 | 7tm_1 - 7 transmembrane receptor (rhodopsin family) | 54~307 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL1940537 |  |
IC50 | = | 4.2 | nM | 570.76 | COc1ccc(C2(N[C@@H]3CC[C@H](C(=O)N4CCN(c5nc6ccccc6o5)CC4)[C@@H](c4ccsc4)C3)CCC2)cc1 | Homo sapiens | CHEMBL1942829 | cell-based format |
| CHEMBL1940539 |  |
IC50 | = | 5.9 | nM | 569.78 | COc1ccc(C2(N[C@@H]3CC[C@H](C(=O)N4CCN(c5nc6ccccc6[nH]5)CC4)[C@@H](c4ccsc4)C3)CCC2)cc1 | Homo sapiens | CHEMBL1942829 | cell-based format |
| CHEMBL1940543 |  |
IC50 | = | 6.0 | nM | 584.79 | COc1ccc(C2(N[C@@H]3CC[C@H](C(=O)N4CCN(c5nc6cc(C)ccc6o5)CC4)[C@@H](c4ccsc4)C3)CCC2)cc1 | Homo sapiens | CHEMBL1942829 | cell-based format |
| CHEMBL1940536 |  |
IC50 | = | 21.0 | nM | 558.75 | COc1ccc(C(C)(C)N[C@@H]2CC[C@H](C(=O)N3CCN(c4nc5ccccc5o4)CC3)[C@@H](c3ccsc3)C2)cc1 | Homo sapiens | CHEMBL1942829 | cell-based format |
| CHEMBL4757321 |  |
IC50 | = | 30.0 | nM | 397.19 | FC(F)(F)c1ccc2[nH]c(-c3c(Cl)cc(-c4cn[nH]c4)cc3Cl)nc2c1 | Homo sapiens | CHEMBL5127362 | single protein format |
| CHEMBL1940538 |  |
IC50 | = | 35.0 | nM | 557.76 | COc1ccc(C(C)(C)N[C@@H]2CC[C@H](C(=O)N3CCN(c4nc5ccccc5[nH]4)CC3)[C@@H](c3ccsc3)C2)cc1 | Homo sapiens | CHEMBL1942829 | cell-based format |
| CHEMBL2314291 |  |
IC50 | = | 100.0 | nM | 406.87 | CCOc1ccc(Oc2c(Cl)cnn(Cc3cccc4ccccc34)c2=O)cc1 | Homo sapiens | CHEMBL2319036 | cell-based format |
| CHEMBL1972527 |  |
IC50 | = | 120.0 | nM | 416.86 | COc1ccc(Oc2c(Cl)cnn(C3c4ccccc4-c4ccccc43)c2=O)cc1 | Homo sapiens | CHEMBL2319036 | cell-based format |
| CHEMBL2314320 |  |
IC50 | = | 140.0 | nM | 392.84 | COc1ccc(Oc2c(Cl)cnn(Cc3cccc4ccccc34)c2=O)cc1 | Homo sapiens | CHEMBL2319036 | cell-based format |
| CHEMBL1981304 |  |
IC50 | = | 220.0 | nM | 408.85 | COc1ccc(Oc2c(Cl)cnn(Cc3ccccc3-n3cccn3)c2=O)cc1 | Homo sapiens | CHEMBL2319036 | cell-based format |
| CHEMBL2314323 |  |
IC50 | = | 220.0 | nM | 406.87 | COc1ccc(Oc2c(Cl)cnn(Cc3c(C)ccc4ccccc34)c2=O)cc1 | Homo sapiens | CHEMBL2319036 | cell-based format |
| CHEMBL1987422 |  |
IC50 | = | 240.0 | nM | 370.84 | COc1ccc(Oc2c(Cl)cnn(Cc3c(C)cccc3C)c2=O)cc1 | Homo sapiens | CHEMBL2319036 | cell-based format |
| CHEMBL2314301 |  |
IC50 | = | 240.0 | nM | 414.89 | CCc1ccc(Oc2c(Cl)cnn(C3c4ccccc4-c4ccccc43)c2=O)cc1 | Homo sapiens | CHEMBL2319036 | cell-based format |
| CHEMBL2314293 |  |
IC50 | = | 250.0 | nM | 390.87 | CCc1ccc(Oc2c(Cl)cnn(Cc3cccc4ccccc34)c2=O)cc1 | Homo sapiens | CHEMBL2319036 | cell-based format |
| CHEMBL2314300 |  |
IC50 | = | 250.0 | nM | 430.89 | CCOc1ccc(Oc2c(Cl)cnn(C3c4ccccc4-c4ccccc43)c2=O)cc1 | Homo sapiens | CHEMBL2319036 | cell-based format |
| CHEMBL1964671 |  |
IC50 | = | 260.0 | nM | 370.84 | CCc1ccccc1Cn1ncc(Cl)c(Oc2ccc(OC)cc2)c1=O | Homo sapiens | CHEMBL2319036 | cell-based format |
| CHEMBL1729021 |  |
IC50 | = | 270.0 | nM | 356.81 | COc1ccc(Oc2c(Cl)cnn(-c3cc(C)cc(C)c3)c2=O)cc1 | Homo sapiens | CHEMBL2319036 | cell-based format |
| CHEMBL1969065 |  |
IC50 | = | 280.0 | nM | 461.91 | COc1ccc(Oc2c(Cl)cnn(CC(=O)N(c3ccccc3)c3ccccc3)c2=O)cc1 | Homo sapiens | CHEMBL2319036 | cell-based format |
| CHEMBL1965488 |  |
IC50 | = | 290.0 | nM | 422.87 | COc1ccc(Oc2c(Cl)cnn(Cc3cccc4ccccc34)c2=O)cc1OC | Homo sapiens | CHEMBL2319036 | cell-based format |
| CHEMBL2314318 |  |
IC50 | = | 320.0 | nM | 442.9 | COc1ccc(Oc2c(Cl)cnn(Cc3c4ccccc4cc4ccccc34)c2=O)cc1 | Homo sapiens | CHEMBL2319036 | cell-based format |