P48067 | SC6A9_HUMAN | Sodium- and chloride-dependent glycine transporter 1 (SLC6A9)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00209 | SNF - Sodium:neurotransmitter symporter family | 100~634 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL485356 |  |
IC50 | = | 0.1 | nM | 458.37 | Cn1cc(S(=O)(=O)N2CC(CNC(=O)c3ccc(Cl)cc3Cl)(CC3CC3)C2)nn1 | Homo sapiens | CHEMBL993724 | cell-based format |
| CHEMBL483938 |  |
IC50 | = | 0.31 | nM | 499.36 | Cn1cc(S(=O)(=O)N2CC(CNC(=O)c3ccc(Cl)cc3Cl)(c3ncccc3F)C2)nn1 | Homo sapiens | CHEMBL993724 | cell-based format |
| CHEMBL379668 |  |
IC50 | = | 0.47 | nM | 450.32 | COc1cc2c(c(Cl)c1Cl)C(=O)C(CCN(C)[C@@H](C)C(=O)O)(c1ccccc1)C2=O | Homo sapiens | CHEMBL867170 | cell-based format |
| CHEMBL521463 |  |
IC50 | = | 0.65 | nM | 527.41 | Cn1cc(S(=O)(=O)N2CCC(CNC(=O)c3ccc(Cl)cc3Cl)(c3ncccc3F)CC2)nn1 | Homo sapiens | CHEMBL993724 | cell-based format |
| CHEMBL206851 |  |
IC50 | = | 0.95 | nM | 454.28 | COc1cc2c(c(Cl)c1Cl)C(=O)C(CCN(C)CC(=O)O)(c1ccc(F)cc1)C2=O | Homo sapiens | CHEMBL867170 | cell-based format |
| CHEMBL4224734 |  |
IC50 | = | 1.0 | nM | 363.51 | Cc1cccc(C)c1C(=O)NC(c1ccncc1)C12CCC(CC1)CN2C | Homo sapiens | CHEMBL4221489 | cell-based format |
| CHEMBL4226364 |  |
IC50 | = | 1.0 | nM | 366.51 | Cc1ccc(C(NC(=O)c2c(C)cccc2C)C23CCC(CC2)CN3C)o1 | Homo sapiens | CHEMBL4221489 | cell-based format |
| CHEMBL3913494 |  |
IC50 | = | 1.0 | nM | 475.46 | O=C(C1CCS(=O)(=O)CC1)N1CCN(c2cc(C(F)(F)F)on2)C[C@H]1c1ccc(F)cc1 | Homo sapiens | CHEMBL3887843 | cell-based format |
| CHEMBL4228975 |  |
IC50 | = | 1.0 | nM | 376.54 | Cc1cccc(C)c1C(=O)NC(c1ccccc1)C12CCC(CC1)N2C(C)C | Homo sapiens | CHEMBL4221489 | cell-based format |
| CHEMBL4225587 |  |
IC50 | = | 1.0 | nM | 480.67 | Cc1cccc(C)c1C(=O)NC(c1ccc(S(=O)(=O)CC2CC2)cc1)C12CCC(CC1)CN2C | Homo sapiens | CHEMBL4221489 | cell-based format |
| CHEMBL4228859 |  |
IC50 | = | 1.0 | nM | 362.52 | Cc1cccc(C)c1C(=O)N[C@H](c1ccccc1)C12CCC(CC1)CN2C | Homo sapiens | CHEMBL4221489 | cell-based format |
| CHEMBL4226039 |  |
IC50 | = | 1.0 | nM | 403.35 | CN1CC2CCC1([C@H](NC(=O)c1cccc(Cl)c1Cl)c1ccccc1)CC2 | Homo sapiens | CHEMBL4221489 | cell-based format |
| CHEMBL3923537 |  |
IC50 | = | 1.0 | nM | 466.53 | O=C(C1CCS(=O)(=O)CC1)N1CCN(c2ccc(C(F)(F)F)cc2)CC1c1ccccc1 | Homo sapiens | CHEMBL3887843 | cell-based format |
| CHEMBL3912223 |  |
IC50 | = | 1.0 | nM | 515.0 | O=C(C1CCS(=O)(=O)CC1)N1CCN(c2nnc(C(F)(F)F)s2)C[C@H]1c1ccc(Cl)s1 | Homo sapiens | CHEMBL3887843 | cell-based format |
| CHEMBL4456392 |  |
IC50 | = | 1.14 | nM | 571.45 | Cl.Cn1cc(S(=O)(=O)N2CCN(C3(CNC(=O)c4ccc(F)cc4Cl)CCC(F)(F)CC3)CC2)nn1 | Homo sapiens | CHEMBL4429876 | cell-based format |
| CHEMBL4582587 |  |
IC50 | = | 1.24 | nM | 587.91 | Cl.Cn1cc(S(=O)(=O)N2CCN(C3(CNC(=O)c4ccc(Cl)cc4Cl)CCC(F)(F)CC3)CC2)nn1 | Homo sapiens | CHEMBL4429876 | cell-based format |
| CHEMBL4516089 |  |
IC50 | = | 1.27 | nM | 587.91 | Cl.Cn1cc(S(=O)(=O)N2CCN(C3(CNC(=O)c4c(Cl)cccc4Cl)CCC(F)(F)CC3)CC2)nn1 | Homo sapiens | CHEMBL4429876 | cell-based format |
| CHEMBL4579165 |  |
IC50 | = | 1.54 | nM | 551.93 | Cl.Cn1cc(S(=O)(=O)N2CCN(C3(CNC(=O)c4ccc(Cl)cc4Cl)CCCCC3)CC2)nn1 | Homo sapiens | CHEMBL4429876 | cell-based format |
| CHEMBL482764 |  |
IC50 | = | 1.74 | nM | 526.42 | Cn1cnc(S(=O)(=O)N2CCC(CNC(=O)c3ccc(Cl)cc3Cl)(c3ncccc3F)CC2)c1 | Homo sapiens | CHEMBL993724 | cell-based format |
| CHEMBL482960 |  |
IC50 | = | 1.89 | nM | 485.44 | Cn1cc(S(=O)(=O)[C@H]2CC[C@@](CNC(=O)c3ccc(Cl)cc3Cl)(CC3CC3)CC2)nn1 | Homo sapiens | CHEMBL993724 | cell-based format |