P48061 | SDF1_HUMAN | Stromal cell-derived factor 1 (CXCL12)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00048 | IL8 - Small cytokines (intecrine/chemokine), interleukin-8 like | 29~85 |
3D structures mapped by conservation among orthologs
[ Domain: "IL8" // IL8_1 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL18442 |  |
IC50 | = | 608.2 | nM | 502.8 | c1cc(CN2CCCNCCNCCCNCC2)ccc1CN1CCCNCCNCCCNCC1 | Homo sapiens | CHEMBL5230397 | cell-based format |
| CHEMBL5283078 |  |
IC50 | = | 621.4 | nM | 414.68 | c1cc(CNCCCNC2CCCCC2)ccc1CNCCCNC1CCCCC1 | Homo sapiens | CHEMBL5230397 | cell-based format |
| CHEMBL4170392 |  |
Ki | = | 25.0 | nM | 296.37 | COc1cc(/C=C/C(=O)c2ccc(C(C)C)cc2)ccc1O | Homo sapiens | CHEMBL4151994 | cell-based format |
| CHEMBL4160309 |  |
Ki | = | 44.0 | nM | 333.18 | COc1cc(/C=C/C(=O)c2ccc(Br)cc2)ccc1O | Homo sapiens | CHEMBL4151994 | cell-based format |
| CHEMBL4160346 |  |
Ki | = | 48.0 | nM | 323.17 | COc1cc(/C=C/C(=O)c2ccc(Cl)cc2Cl)ccc1O | Homo sapiens | CHEMBL4151994 | cell-based format |
| CHEMBL126657 |  |
Ki | = | 53.0 | nM | 288.73 | COc1cc(/C=C/C(=O)c2ccc(Cl)cc2)ccc1O | Homo sapiens | CHEMBL4151994 | cell-based format |
| CHEMBL4167574 |  |
Ki | = | 53.0 | nM | 323.17 | COc1cc(/C=C/C(=O)c2cc(Cl)ccc2Cl)ccc1O | Homo sapiens | CHEMBL4151994 | cell-based format |
| CHEMBL4175451 |  |
Ki | = | 71.0 | nM | 323.17 | COc1cc(/C=C/C(=O)c2c(Cl)cccc2Cl)ccc1O | Homo sapiens | CHEMBL4151994 | cell-based format |
| CHEMBL4168220 |  |
Ki | = | 107.0 | nM | 380.18 | COc1cc(/C=C/C(=O)c2ccc(I)cc2)ccc1O | Homo sapiens | CHEMBL4151994 | cell-based format |
| CHEMBL4168923 |  |
Ki | = | 107.0 | nM | 306.72 | COc1cc(/C=C/C(=O)c2ccc(Cl)cc2F)ccc1O | Homo sapiens | CHEMBL4151994 | cell-based format |
| CHEMBL4163005 |  |
Ki | = | 107.0 | nM | 300.74 | COc1cc(/C=C2\Cc3cc(Cl)ccc3C2=O)ccc1O | Homo sapiens | CHEMBL4151994 | cell-based format |
| CHEMBL4169628 |  |
Ki | = | 107.0 | nM | 302.76 | COc1cc(C2CC(c3ccc(Cl)cc3)=NN2)ccc1O | Homo sapiens | CHEMBL4151994 | cell-based format |
| CHEMBL4166275 |  |
Ki | = | 107.0 | nM | 288.73 | COc1cc(/C=C/C(=O)c2ccccc2Cl)ccc1O | Homo sapiens | CHEMBL4151994 | cell-based format |
| CHEMBL4160583 |  |
Ki | = | 203.0 | nM | 302.71 | COc1cc(/C=C2\Oc3cc(Cl)ccc3C2=O)ccc1O | Homo sapiens | CHEMBL4151994 | cell-based format |
| CHEMBL4166454 |  |
Ki | = | 267.0 | nM | 328.76 | COc1cc(-c2cc(-c3ccc(Cl)cc3)nc(=O)[nH]2)ccc1O | Homo sapiens | CHEMBL4151994 | cell-based format |
| CHEMBL4173832 |  |
Ki | = | 285.0 | nM | 268.31 | COc1cc(/C=C/C(=O)c2ccc(C)cc2)ccc1O | Homo sapiens | CHEMBL4151994 | cell-based format |
| CHEMBL127593 |  |
Ki | = | 350.0 | nM | 274.7 | O=C(/C=C/c1ccc(O)c(O)c1)c1ccc(Cl)cc1 | Homo sapiens | CHEMBL4151994 | cell-based format |
| CHEMBL4175213 |  |
Ki | = | 357.0 | nM | 354.23 | Cl.NCCOc1cc(/C=C/C(=O)c2ccc(Cl)cc2)ccc1O | Homo sapiens | CHEMBL4151994 | cell-based format |
| CHEMBL4170951 |  |
Ki | = | 357.0 | nM | 323.17 | COc1cc(/C=C/C(=O)c2cccc(Cl)c2Cl)ccc1O | Homo sapiens | CHEMBL4151994 | cell-based format |
| CHEMBL4162605 |  |
Ki | = | 357.0 | nM | 316.74 | COc1cc(/C=C2\COc3cc(Cl)ccc3C2=O)ccc1O | Homo sapiens | CHEMBL4151994 | cell-based format |