P48048 | KCNJ1_HUMAN | ATP-sensitive inward rectifier potassium channel 1 (KCNJ1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF01007 | IRK - Inward rectifier potassium channel transmembrane domain | 43~185 | |
| PF17655 | IRK_C - Inward rectifier potassium channel C-terminal domain | 192~363 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3696475 |  |
IC50 | = | 6.0 | nM | 466.53 | Cc1c([C@@H](O)CN2CCN(C[C@H](O)c3ccc4c(c3C)COC4=O)CC2)ccc2c1COC2=O | Homo sapiens | CHEMBL4427473 | single protein format |
| CHEMBL4548110 |  |
IC50 | = | 6.2 | nM | 432.48 | CCOc1cc(-n2cc(CNC[C@H](O)c3ccc4c(c3C)COC4=O)cn2)ccc1C#N | Homo sapiens | CHEMBL4322078 | cell-based format |
| CHEMBL4549009 |  |
IC50 | = | 6.6 | nM | 443.51 | Cc1cc(-c2cc(CN3C[C@@H](c4ccc5c(c4C)COC5=O)N[C@@H](C)C3)on2)ncc1C#N | Homo sapiens | CHEMBL4322078 | cell-based format |
| CHEMBL4563446 |  |
IC50 | = | 6.6 | nM | 419.51 | Cc1cc(-c2ncc(CNC[C@H](O)c3ccc4c(c3C)COC4=O)s2)ccc1C#N | Homo sapiens | CHEMBL4322078 | cell-based format |
| CHEMBL3808666 |  |
IC50 | = | 7.0 | nM | 450.5 | C[C@@H]1CC2(CCN(C[C@@H](O)c3ccc4c(c3)-c3nnnn3C4)CC2)C(=O)N1C1=CC(=O)OC1 | Homo sapiens | CHEMBL3811738 | cell-based format |
| CHEMBL5205738 |  |
IC50 | = | 7.0 | nM | 444.5 | Cc1c([C@H](O)CN2CCC3(CC2)CCN(C2=C(F)C(=O)OC2)CC3)ccc2c1COC2=O | Homo sapiens | CHEMBL5105294 | single protein format |
| CHEMBL4062753 |  |
IC50 | = | 8.0 | nM | 427.53 | Cc1c([C@@H](O)CN2CCC3(CC2)CCN(c2ccns2)C3=O)ccc2c1COC2=O | Homo sapiens | CHEMBL4030011 | cell-based format |
| CHEMBL4462473 |  |
IC50 | = | 8.8 | nM | 414.47 | Cc1c([C@@H]2CN(Cc3ccc(-n4cc(C#N)cn4)cn3)CCN2)ccc2c1COC2=O | Homo sapiens | CHEMBL4322078 | cell-based format |
| CHEMBL3808614 |  |
IC50 | = | 9.0 | nM | 484.94 | CC1=C(N2CCC3(CCN(C[C@@H](O)c4cc5c(cc4Cl)Cn4nnnc4-5)CC3)C2=O)COC1=O | Homo sapiens | CHEMBL3811738 | cell-based format |
| CHEMBL3696477 |  |
IC50 | = | 9.0 | nM | 466.53 | Cc1c([C@H](O)CN2CCN(C[C@H](O)c3ccc4c(c3C)COC4=O)CC2)ccc2c1COC2=O | Homo sapiens | CHEMBL4427470 | cell-based format |
| CHEMBL3622114 |  |
IC50 | = | 9.0 | nM | 447.54 | Cc1c([C@@H](O)CN2CCC3(CC2)CCN(c2cnc(C#N)cn2)CC3)ccc2c1COC2=O | Homo sapiens | CHEMBL3626480 | cell-based format |
| CHEMBL3962588 |  |
IC50 | = | 10.0 | nM | 460.91 | Cc1c([C@@H](O)CN2CCC3(CC2)CCN(C2=C(Cl)C(=O)OC2)C3=O)ccc2c1COC2=O | Homo sapiens | CHEMBL3887676 | assay format |
| CHEMBL3897405 |  |
IC50 | = | 10.0 | nM | 466.53 | CC1=C(N2CCC3(CCN(CC(O)c4ccc5c(c4C4CC4)COC5=O)CC3)C2=O)COC1=O | Homo sapiens | CHEMBL3887676 | assay format |
| CHEMBL3902424 |  |
IC50 | = | 10.0 | nM | 454.52 | CCC1CC2(CCN(C[C@H](O)c3ccc4c(c3C)COC4=O)CC2)C(=O)N1C1=CC(=O)OC1 | Homo sapiens | CHEMBL3887676 | assay format |
| CHEMBL4108107 |  |
IC50 | = | 10.0 | nM | 454.52 | CC1=C(N2CCC3(CCN([C@H](C)[C@@H](O)c4ccc5c(c4C)COC5=O)CC3)C2=O)COC1=O | Homo sapiens | CHEMBL3887676 | assay format |
| CHEMBL3906190 |  |
IC50 | = | 10.0 | nM | 454.52 | CC1=C(N2CCC3(CCN([C@@H](C)[C@H](O)c4ccc5c(c4C)COC5=O)CC3)C2=O)COC1=O | Homo sapiens | CHEMBL3887676 | assay format |
| CHEMBL3622105 |  |
IC50 | = | 10.0 | nM | 432.52 | Cc1c([C@@H](O)CN2CCC3(CC2)CCN(c2ccc(C#N)cn2)C3)ccc2c1COC2=O | Homo sapiens | CHEMBL3626480 | cell-based format |
| CHEMBL4079335 |  |
IC50 | = | 10.0 | nM | 446.51 | Cc1c([C@@H](O)CN2CCC3(CC2)CC(=O)N(c2cncc(C#N)c2)C3)ccc2c1COC2=O | Homo sapiens | CHEMBL4004311 | cell-based format |
| CHEMBL3906183 |  |
IC50 | = | 10.0 | nM | 424.5 | CC1=C(N2CCC3(CCN(CCc4ccc5c(c4C)COC5=O)CC3)C2=O)COC1=O | Homo sapiens | CHEMBL3887676 | assay format |
| CHEMBL3893871 |  |
IC50 | = | 10.0 | nM | 440.5 | Cc1c([C@@H](O)CN2CCC3(CC2)C[C@H](C)N(C2=CC(=O)OC2)C3=O)ccc2c1COC2=O | Homo sapiens | CHEMBL3887676 | assay format |