P47901 | V1BR_HUMAN | Vasopressin V1b receptor (AVPR1B)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00001 | 7tm_1 - 7 transmembrane receptor (rhodopsin family) | 51~338 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL1778961 |  |
IC50 | = | 1.0 | nM | 502.59 | COc1cc(-c2nc3ccc(-c4cccc(CN(C)C)c4)cc3c(=O)n2CC(=O)NC(C)C)ccc1F | Homo sapiens | CHEMBL1780922 | cell-based format |
| CHEMBL1778950 |  |
IC50 | = | 2.0 | nM | 524.67 | COc1cccc(-c2nc3ccc(-c4cccc(CN5CCCCC5)c4)cc3c(=O)n2CC(=O)NC(C)C)c1 | Homo sapiens | CHEMBL1780922 | cell-based format |
| CHEMBL1684573 |  |
IC50 | = | 3.0 | nM | 492.62 | COc1cccc(-c2nc3ccc(OCCCN4CCCCC4)cc3c(=O)n2CC(=O)NC(C)C)c1 | Homo sapiens | CHEMBL1686964 | cell-based format |
| CHEMBL1684561 |  |
IC50 | = | 4.0 | nM | 494.59 | COc1cccc(-c2nc3ccc(OCCCN4CCOCC4)cc3c(=O)n2CC(=O)NC(C)C)c1 | Homo sapiens | CHEMBL1686964 | cell-based format |
| CHEMBL1684562 |  |
IC50 | = | 5.0 | nM | 499.01 | CC(C)NC(=O)Cn1c(-c2cccc(Cl)c2)nc2ccc(OCCCN3CCOCC3)cc2c1=O | Homo sapiens | CHEMBL1686964 | cell-based format |
| CHEMBL1684574 |  |
IC50 | = | 6.0 | nM | 497.04 | CC(C)NC(=O)Cn1c(-c2cccc(Cl)c2)nc2ccc(OCCCN3CCCCC3)cc2c1=O | Homo sapiens | CHEMBL1686964 | cell-based format |
| CHEMBL1778960 |  |
IC50 | = | 7.0 | nM | 502.59 | COc1cccc(-c2nc3ccc(-c4cc(CN(C)C)ccc4F)cc3c(=O)n2CC(=O)NC(C)C)c1 | Homo sapiens | CHEMBL1780922 | cell-based format |
| CHEMBL1778953 |  |
IC50 | = | 9.0 | nM | 529.08 | CC(C)NC(=O)Cn1c(-c2cccc(Cl)c2)nc2ccc(-c3cccc(CN4CCCCC4)c3)cc2c1=O | Homo sapiens | CHEMBL1780922 | cell-based format |
| CHEMBL1778948 |  |
IC50 | = | 9.0 | nM | 484.6 | COc1cccc(-c2nc3ccc(-c4cccc(CN(C)C)c4)cc3c(=O)n2CC(=O)NC(C)C)c1 | Homo sapiens | CHEMBL1780922 | cell-based format |
| CHEMBL1684408 |  |
IC50 | = | 15.0 | nM | 506.6 | COc1cccc(-c2nc3ccc(OCCCN4CCOCC4)cc3c(=O)n2CC(=O)NCC2CC2)c1 | Homo sapiens | CHEMBL1686964 | cell-based format |
| CHEMBL1684571 |  |
IC50 | = | 17.0 | nM | 490.6 | COc1cccc(-c2nc3ccc(OCCCN4CCCCC4)cc3c(=O)n2CC(=O)NC2CC2)c1 | Homo sapiens | CHEMBL1686964 | cell-based format |
| CHEMBL1778951 |  |
IC50 | = | 19.0 | nM | 489.02 | CC(C)NC(=O)Cn1c(-c2cccc(Cl)c2)nc2ccc(-c3cccc(CN(C)C)c3)cc2c1=O | Homo sapiens | CHEMBL1780922 | cell-based format |
| CHEMBL1684560 |  |
IC50 | = | 26.0 | nM | 497.0 | O=C(Cn1c(-c2cccc(Cl)c2)nc2ccc(OCCCN3CCOCC3)cc2c1=O)NC1CC1 | Homo sapiens | CHEMBL1686964 | cell-based format |
| CHEMBL1684409 |  |
IC50 | = | 30.0 | nM | 511.02 | O=C(Cn1c(-c2cccc(Cl)c2)nc2ccc(OCCCN3CCOCC3)cc2c1=O)NCC1CC1 | Homo sapiens | CHEMBL1686964 | cell-based format |
| CHEMBL1684559 |  |
IC50 | = | 34.0 | nM | 492.58 | COc1cccc(-c2nc3ccc(OCCCN4CCOCC4)cc3c(=O)n2CC(=O)NC2CC2)c1 | Homo sapiens | CHEMBL1686964 | cell-based format |
| CHEMBL1778957 |  |
IC50 | = | 37.0 | nM | 485.59 | COc1cccc(-c2nc3ccc(-c4cccc(CN(C)C)n4)cc3c(=O)n2CC(=O)NC(C)C)c1 | Homo sapiens | CHEMBL1780922 | cell-based format |
| CHEMBL1684557 |  |
IC50 | = | 42.0 | nM | 494.59 | CCCNC(=O)Cn1c(-c2cccc(OC)c2)nc2ccc(OCCCN3CCOCC3)cc2c1=O | Homo sapiens | CHEMBL1686964 | cell-based format |
| CHEMBL1684572 |  |
IC50 | = | 46.0 | nM | 495.02 | O=C(Cn1c(-c2cccc(Cl)c2)nc2ccc(OCCCN3CCCCC3)cc2c1=O)NC1CC1 | Homo sapiens | CHEMBL1686964 | cell-based format |
| CHEMBL1778949 |  |
IC50 | = | 46.0 | nM | 496.61 | COc1cccc(-c2nc3ccc(-c4cccc(CN5CCC5)c4)cc3c(=O)n2CC(=O)NC(C)C)c1 | Homo sapiens | CHEMBL1780922 | cell-based format |
| CHEMBL1684570 |  |
IC50 | = | 49.0 | nM | 497.04 | CCCNC(=O)Cn1c(-c2cccc(Cl)c2)nc2ccc(OCCCN3CCCCC3)cc2c1=O | Homo sapiens | CHEMBL1686964 | cell-based format |