P47900 | P2RY1_HUMAN | P2Y purinoceptor 1 (P2RY1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00001 | 7tm_1 - 7 transmembrane receptor (rhodopsin family) | 68~324 |
3D structures mapped by conservation among orthologs
[ Domain: "Family A G protein-coupled receptor-like" // 7tm_1_1 ]
[ Domain: "Rubredoxin-related" // Rubredoxin ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3287050 |  |
IC50 | = | 0.03 | nM | 560.55 | CC(C)(C)CN1CCC2(CC1)CN(c1ccccc1NC(=O)Nc1csc(Cl)n1)c1c(O)ccc(Cl)c12 | Homo sapiens | CHEMBL3292933 | assay format |
| CHEMBL3287043 |  |
IC50 | = | 0.04 | nM | 593.65 | CC(C)(C)CN1CCC2(CC1)CN(c1ccccc1NC(=O)Nc1ccc(OC(F)(F)F)cc1)c1c(O)ccc(C#N)c12 | Homo sapiens | CHEMBL3292933 | assay format |
| CHEMBL3287049 |  |
IC50 | = | 0.06 | nM | 594.16 | CC(C)(C)CN1CCC2(CC1)CN(c1ccccc1NC(=O)Nc1nc3ccc(F)cc3s1)c1c(O)ccc(Cl)c12 | Homo sapiens | CHEMBL3292933 | assay format |
| CHEMBL3287051 |  |
IC50 | = | 0.08 | nM | 587.09 | CC(C)(C)CN1CCC2(CC1)CN(c1ccccc1NC(=O)Nc1ccc(C(F)(F)F)cc1)c1c(O)ccc(Cl)c12 | Homo sapiens | CHEMBL3292933 | assay format |
| CHEMBL3287047 |  |
IC50 | = | 0.23 | nM | 568.64 | CC(C)(C)CN1CCC2(CC1)CN(c1ccccc1NC(=O)Nc1ccc(OC(F)(F)F)cc1)c1c(O)cccc12 | Homo sapiens | CHEMBL3292933 | assay format |
| CHEMBL3287045 |  |
IC50 | = | 0.37 | nM | 586.63 | CC(C)(C)CN1CCC2(CC1)CN(c1ccccc1NC(=O)Nc1ccc(OC(F)(F)F)cc1)c1c(O)ccc(F)c12 | Homo sapiens | CHEMBL3292933 | assay format |
| CHEMBL3287046 |  |
IC50 | = | 4.6 | nM | 568.64 | CC(C)(C)CN1CCC2(CC1)CN(c1ccccc1NC(=O)Nc1ccc(OC(F)(F)F)cc1)c1cc(O)ccc12 | Homo sapiens | CHEMBL3292933 | assay format |
| CHEMBL3263058 |  |
IC50 | = | 6.0 | nM | 560.17 | CC(C)(C)CN1CCC2(CC1)CN(c1ccccc1Nc1nc(-c3ccccc3)ns1)c1c(O)ccc(Cl)c12 | Homo sapiens | CHEMBL3887218 | assay format |
| CHEMBL3903953 |  |
IC50 | = | 6.0 | nM | 578.16 | CC(C)(C)CN1CCC2(CC1)CN(c1ccccc1Nc1nnc(-c3ccc(Cl)cc3)s1)c1c(O)ccc(F)c12 | Homo sapiens | CHEMBL3887218 | assay format |
| CHEMBL3904405 |  |
IC50 | = | 6.3 | nM | 572.7 | CCOC(=O)c1sc(Nc2ccccc2N2CC3(CCN(CC(C)(C)C)CC3)c3ccccc32)nc1C(F)(F)F | Homo sapiens | CHEMBL3887217 | cell-based format |
| CHEMBL3263075 |  |
IC50 | = | 6.5 | nM | 562.14 | CC(C)(C)CN1CCC2(CC1)CN(c1ccccc1Nc1nnc(-c3cnccn3)s1)c1c(O)ccc(Cl)c12 | Homo sapiens | CHEMBL3887217 | cell-based format |
| CHEMBL3263076 |  |
IC50 | = | 6.6 | nM | 578.19 | Cc1cc(-c2nnc(Nc3ccccc3N3CC4(CCN(CC(C)(C)C)CC4)c4c(Cl)ccc(O)c43)s2)n(C)n1 | Homo sapiens | CHEMBL3887217 | cell-based format |
| CHEMBL3932713 |  |
IC50 | = | 6.8 | nM | 561.16 | CC(C)(C)CN1CCC2(CC1)CN(c1ccccc1Nc1nnc(-c3ccccn3)s1)c1c(O)ccc(Cl)c12 | Homo sapiens | CHEMBL3887218 | assay format |
| CHEMBL3943381 |  |
IC50 | = | 7.9 | nM | 576.73 | CC(C)(C)CN1CCC2(CC1)CN(c1ccccc1Nc1nc(C(F)(F)F)c(-c3ccccc3)s1)c1ccccc12 | Homo sapiens | CHEMBL3887217 | cell-based format |
| CHEMBL3967844 |  |
IC50 | = | 8.0 | nM | 540.18 | CC(C)(C)CN1CCC2(CC1)CN(c1ccccc1Nc1nc(C(C)(C)C)ns1)c1c(O)ccc(Cl)c12 | Homo sapiens | CHEMBL3887218 | assay format |
| CHEMBL3973199 |  |
IC50 | = | 9.0 | nM | 564.2 | CC(C)(C)CN1CCC2(CC1)CN(c1ccccc1Nc1nc(C(C)(C)C)c(C#N)s1)c1c(O)ccc(Cl)c12 | Homo sapiens | CHEMBL3887218 | assay format |
| CHEMBL3263057 |  |
IC50 | = | 10.0 | nM | 593.72 | CC(C)(C)CN1CCC2(CC1)CN(c1ccccc1Nc1nnc(-c3ccccc3)s1)c1c(O)ccc(C(F)(F)F)c12 | Homo sapiens | CHEMBL3887218 | assay format |
| CHEMBL3900332 |  |
IC50 | = | 11.0 | nM | 594.71 | CC(C)(C)CN1CCC2(CC1)CN(c1ccccc1Nc1nnc(-c3ccccn3)s1)c1c(O)ccc(C(F)(F)F)c12 | Homo sapiens | CHEMBL3887218 | assay format |
| CHEMBL3263074 |  |
IC50 | = | 13.0 | nM | 594.61 | CC(C)(C)CN1CCC2(CC1)CN(c1ccccc1Nc1nnc(-c3ccc(Cl)cc3)s1)c1c(O)ccc(Cl)c12 | Homo sapiens | CHEMBL3887218 | assay format |
| CHEMBL3263062 |  |
IC50 | = | 16.0 | nM | 559.18 | CC(C)(C)CN1CCC2(CC1)CN(c1ccccc1Nc1ncc(-c3ccccc3)s1)c1c(O)ccc(Cl)c12 | Homo sapiens | CHEMBL3887218 | assay format |