P47895 | AL1A3_HUMAN | Aldehyde dehydrogenase family 1 member A3 (ALDH1A3)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00171 | Aldedh - Aldehyde dehydrogenase family | 40~503 |
3D structures mapped by conservation among orthologs
[ Domain: "ALDH-like" // Aldedh_2nd ]
[ Domain: "ALDH-like" // Aldedh_1st_1 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4876602 |  |
IC50 | = | 34.0 | nM | 362.46 | C[C@@H](Sc1nc2c(cnn2C)c(=O)n1-c1ccccc1)c1ccccc1 | Homo sapiens | CHEMBL4811566 | single protein format |
| CHEMBL4861872 |  |
IC50 | = | 50.0 | nM | 418.52 | CC(Sc1nc2nn(C3(C)COC3)cc2c(=O)n1-c1ccccc1)c1ccccc1 | Homo sapiens | CHEMBL4811566 | single protein format |
| CHEMBL4859904 |  |
IC50 | = | 60.0 | nM | 418.52 | CC(Sc1nc2nn(CC3COC3)cc2c(=O)n1-c1ccccc1)c1ccccc1 | Homo sapiens | CHEMBL4811566 | single protein format |
| CHEMBL4848258 |  |
IC50 | = | 73.0 | nM | 362.46 | CC(Sc1nc2c(cnn2C)c(=O)n1-c1ccccc1)c1ccccc1 | Homo sapiens | CHEMBL4811566 | single protein format |
| CHEMBL4875157 |  |
IC50 | = | 89.0 | nM | 363.45 | CC(Sc1nc2c(cnn2C)c(=O)n1-c1ccccc1)c1ccccn1 | Homo sapiens | CHEMBL4811566 | single protein format |
| CHEMBL4213331 |  |
IC50 | = | 90.0 | nM | 366.42 | Cn1ncc2c(=O)n(-c3ccccc3)c(SCc3cccc(F)c3)nc21 | Homo sapiens | CHEMBL4202010 | single protein format |
| CHEMBL4848831 |  |
IC50 | = | 91.0 | nM | 378.46 | CC(Sc1nc2c(cnn2C)c(=O)n1-c1ccccc1)c1cccc(O)c1 | Homo sapiens | CHEMBL4811566 | single protein format |
| CHEMBL4855442 |  |
IC50 | = | 95.0 | nM | 363.45 | CC(Sc1nc2c(cnn2C)c(=O)n1-c1ccccc1)c1cccnc1 | Homo sapiens | CHEMBL4811566 | single protein format |
| CHEMBL5271934 |  |
IC50 | < | 100.0 | nM | 410.47 | CN(C)c1nc(-c2cccc(F)c2)c(C(=O)Nc2ccc3c(c2)CCC(=O)N3)s1 | Homo sapiens | CHEMBL5226245 | single protein format |
| CHEMBL5291299 |  |
IC50 | < | 100.0 | nM | 367.41 | O=C1CCc2cc(NC(=O)c3scnc3-c3ccccc3F)ccc2N1 | Homo sapiens | CHEMBL5226245 | single protein format |
| CHEMBL5283146 |  |
IC50 | < | 100.0 | nM | 354.43 | O=C1CCc2cc(OCCN3CCCC3c3cccc(F)c3)ccc2N1 | Homo sapiens | CHEMBL5226245 | single protein format |
| CHEMBL5286018 |  |
IC50 | < | 100.0 | nM | 451.53 | O=C1CCc2cc(NC(=O)c3sc(N4CCNCC4)nc3-c3cccc(F)c3)ccc2N1 | Homo sapiens | CHEMBL5226245 | single protein format |
| CHEMBL5274968 |  |
IC50 | < | 100.0 | nM | 367.41 | O=C1CCc2cc(NC(=O)c3scnc3-c3cccc(F)c3)ccc2N1 | Homo sapiens | CHEMBL5226245 | single protein format |
| CHEMBL5278448 |  |
IC50 | < | 100.0 | nM | 438.48 | O=C1CCc2cc(NC(=O)c3sc(N4CC(O)C4)nc3-c3cccc(F)c3)ccc2N1 | Homo sapiens | CHEMBL5226245 | single protein format |
| CHEMBL4849624 |  |
IC50 | = | 100.0 | nM | 364.43 | CC(Sc1nc2c(cnn2C)c(=O)n1-c1ccccc1)c1cncnc1 | Homo sapiens | CHEMBL4811566 | single protein format |
| CHEMBL5269320 |  |
IC50 | < | 100.0 | nM | 354.43 | O=C1CCc2cc(OCCN3CCC[C@@H]3c3cccc(F)c3)ccc2N1 | Homo sapiens | CHEMBL5226245 | single protein format |
| CHEMBL5285815 |  |
IC50 | < | 100.0 | nM | 452.51 | O=C1CCc2cc(NC(=O)c3sc(N4CCOCC4)nc3-c3cccc(F)c3)ccc2N1 | Homo sapiens | CHEMBL5226245 | single protein format |
| CHEMBL4847114 |  |
IC50 | = | 109.0 | nM | 404.5 | CC(Sc1nc2nn(C3COC3)cc2c(=O)n1-c1ccccc1)c1ccccc1 | Homo sapiens | CHEMBL4811566 | single protein format |
| CHEMBL4874309 |  |
IC50 | = | 112.0 | nM | 392.48 | COc1ccccc1C(C)Sc1nc2c(cnn2C)c(=O)n1-c1ccccc1 | Homo sapiens | CHEMBL4811566 | single protein format |
| CHEMBL4876076 |  |
IC50 | = | 119.0 | nM | 376.49 | CCC(Sc1nc2c(cnn2C)c(=O)n1-c1ccccc1)c1ccccc1 | Homo sapiens | CHEMBL4811566 | single protein format |