P47869 | GBRA2_HUMAN | Gamma-aminobutyric acid receptor subunit alpha-2 (GABRA2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF02931 | Neur_chan_LBD - Neurotransmitter-gated ion-channel ligand binding domain | 43~250 | |
| PF02932 | Neur_chan_memb - Neurotransmitter-gated ion-channel transmembrane region | 257~341 | |
| PF02932 | Neur_chan_memb - Neurotransmitter-gated ion-channel transmembrane region | 371~437 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL1681887 |  |
IC50 | = | 2.0 | nM | 403.84 | Fc1ccccc1-n1nc2c(cnc3ccccc32)c1OCc1ccccc1Cl | Homo sapiens | CHEMBL1687498 | cell-based format |
| CHEMBL20042 |  |
IC50 | = | 4.0 | nM | 295.73 | O=C1C2C=Nc3ccccc3C2=NN1c1ccc(Cl)cc1 | Homo sapiens | CHEMBL1687498 | cell-based format |
| CHEMBL2008708 |  |
IC50 | = | 12.0 | nM | 258.28 | c1ccc2c(c1)[nH]c1cnc3c4cccnc4[nH]c3c12 | Homo sapiens | CHEMBL5235583 | single protein format |
| CHEMBL5281056 |  |
IC50 | = | 24.0 | nM | 258.28 | c1ccc2c(c1)[nH]c1cnc3c4ccncc4[nH]c3c12 | Homo sapiens | CHEMBL5235583 | single protein format |
| CHEMBL1681897 |  |
IC50 | = | 57.0 | nM | 407.88 | Fc1ccc(COc2c3cnc4c(c3nn2-c2ccc(Cl)cc2)CCCC4)cc1 | Homo sapiens | CHEMBL1687498 | cell-based format |
| CHEMBL1681895 |  |
IC50 | = | 154.0 | nM | 407.88 | Fc1ccccc1COc1c2cnc3c(c2nn1-c1ccc(Cl)cc1)CCCC3 | Homo sapiens | CHEMBL1687498 | cell-based format |
| CHEMBL1681888 |  |
IC50 | = | 155.0 | nM | 429.86 | Clc1ccccc1COc1c2cnc3ccccc3c2nn1-c1ccc2c(c1)OCO2 | Homo sapiens | CHEMBL1687498 | cell-based format |
| CHEMBL1681894 |  |
IC50 | = | 177.0 | nM | 424.33 | Clc1ccc(COc2c3cnc4c(c3nn2-c2ccc(Cl)cc2)CCCC4)cc1 | Homo sapiens | CHEMBL1687498 | cell-based format |
| CHEMBL1681900 |  |
IC50 | = | 185.0 | nM | 353.85 | Clc1ccc(-n2nc3c4c(ncc3c2OCC2CC2)CCCC4)cc1 | Homo sapiens | CHEMBL1687498 | cell-based format |
| CHEMBL1681892 |  |
IC50 | = | 213.0 | nM | 452.39 | CC1(C)CCc2ncc3c(OCc4ccccc4Cl)n(-c4ccc(Cl)cc4)nc3c2C1 | Homo sapiens | CHEMBL1687498 | cell-based format |
| CHEMBL1681886 |  |
IC50 | = | 265.0 | nM | 420.3 | Clc1ccc(-n2nc3c(cnc4ccccc43)c2OCc2ccccc2Cl)cc1 | Homo sapiens | CHEMBL1687498 | cell-based format |
| CHEMBL1681889 |  |
IC50 | = | 271.0 | nM | 424.33 | Clc1ccc(-n2nc3c4c(ncc3c2OCc2ccccc2Cl)CCCC4)cc1 | Homo sapiens | CHEMBL1687498 | cell-based format |
| CHEMBL1681891 |  |
IC50 | = | 461.0 | nM | 426.3 | Clc1ccc(-n2nc3c4c(ncc3c2OCc2ccccc2Cl)CCOC4)cc1 | Homo sapiens | CHEMBL1687498 | cell-based format |
| CHEMBL1681885 |  |
IC50 | = | 472.0 | nM | 349.82 | Clc1ccc(-n2nc3c(cnc4ccccc43)c2OCC2CC2)cc1 | Homo sapiens | CHEMBL1687498 | cell-based format |
| CHEMBL1681890 |  |
IC50 | = | 605.0 | nM | 438.36 | Clc1ccc(-n2nc3c4c(ncc3c2OCc2ccccc2Cl)CCCCC4)cc1 | Homo sapiens | CHEMBL1687498 | cell-based format |
| CHEMBL44533 |  |
Ki | = | 0.3 | nM | 385.49 | Cc1csc(-c2cc(-c3ccccc3)c3n(c2=O)CCCc2ccncc2-3)n1 | Homo sapiens | CHEMBL678890 | cell-based format |
| CHEMBL1783282 |  |
Ki | = | 0.3 | nM | 354.39 | CCCNC(=O)c1nnc2c(-c3c(F)cccc3OC)cccc2c1N | Homo sapiens | CHEMBL4403717 | single protein format |
| CHEMBL306422 |  |
Ki | = | 0.58 | nM | 362.35 | Cc1cc(-c2nnc3c4ccccc4c(OCc4cn(C)nn4)nn23)no1 | Homo sapiens | CHEMBL4403717 | single protein format |
| CHEMBL45198 |  |
Ki | = | 0.6 | nM | 386.48 | Cc1csc(-c2cc(-c3ccncc3)c3n(c2=O)CCCc2ccncc2-3)n1 | Homo sapiens | CHEMBL2327955 | single protein format |
| CHEMBL373250 |  |
Ki | = | 0.7 | nM | 399.41 | Cn1ncnc1COc1nn2c(-c3cc(F)ccc3F)nnc2cc1C(C)(C)C | Homo sapiens | CHEMBL2327955 | single protein format |