P47712 | PA24A_HUMAN | Cytosolic phospholipase A2 (PLA2G4A)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00168 | C2 - C2 domain | 19~118 | |
| PF01735 | PLA2_B - Lysophospholipase catalytic domain | 190~674 |
3D structures mapped by conservation among orthologs
[ Domain: "C2 domain" // C2_1 ]
[ Domain: "FabD/lysophospholipase-like" // PLA2_B ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL443834 |  |
IC50 | = | 4.3 | nM | 523.63 | CCCCCCCCCCOc1ccc(OCC(=O)Cn2cc(C(=O)OC)c3cc(C(=O)O)ccc32)cc1 | Homo sapiens | CHEMBL863829 | single protein format |
| CHEMBL426665 |  |
IC50 | = | 4.9 | nM | 479.57 | CCCCCCCCc1ccc(OCC(=O)Cn2cc(C(=O)OC)c3cc(C(=O)O)ccc32)cc1 | Homo sapiens | CHEMBL863829 | single protein format |
| CHEMBL484413 |  |
IC50 | = | 5.0 | nM | 422.53 | CCCCCCCCc1ccc(OCC(=O)Cn2ncc3cc(C(=O)O)ccc32)cc1 | Homo sapiens | CHEMBL982355 | assay format |
| CHEMBL3326971 |  |
IC50 | = | 7.0 | nM | 427.54 | CCCOc1ccc(-n2cc(CCc3ccccc3)c3cc(CCC(=O)O)ccc32)cc1 | Homo sapiens | CHEMBL3361803 | single protein format |
| CHEMBL3327088 |  |
IC50 | = | 7.0 | nM | 427.54 | CC(C)Oc1ccc(-n2cc(CCc3ccccc3)c3cc(CCC(=O)O)ccc32)cc1 | Homo sapiens | CHEMBL3361803 | single protein format |
| CHEMBL4097068 |  |
IC50 | = | 10.0 | nM | 491.63 | CCCCCCCCc1ccc(OCC(=O)Cn2cc(C(=O)C(C)C)c3cc(C(=O)O)ccc32)cc1 | Homo sapiens | CHEMBL4000778 | assay format |
| CHEMBL1800991 |  |
IC50 | = | 10.0 | nM | 491.63 | CCCCCCCCc1ccc(OCC(=O)Cn2cc(C(=O)CCC)c3cc(C(=O)O)ccc32)cc1 | Homo sapiens | CHEMBL4000778 | assay format |
| CHEMBL3326966 |  |
IC50 | = | 11.0 | nM | 385.46 | O=C(O)CCc1ccc2c(c1)c(CCc1ccccc1)cn2-c1ccc(O)cc1 | Homo sapiens | CHEMBL3361803 | single protein format |
| CHEMBL30108 |  |
IC50 | = | 11.0 | nM | 442.55 | CCCCCCCCCCOc1ccc(OCC(=O)COc2ccc(C(=O)O)cc2)cc1 | Homo sapiens | CHEMBL863829 | single protein format |
| CHEMBL1085637 |  |
IC50 | = | 12.0 | nM | 471.51 | CC(C)C(=O)c1cn(CC(=O)COc2ccc(Oc3ccccc3)cc2)c2ccc(C(=O)O)cc12 | Homo sapiens | CHEMBL4000778 | assay format |
| CHEMBL3327089 |  |
IC50 | = | 14.0 | nM | 550.65 | NC(CO)(CO)CO.O=C(O)CCc1ccc2c(c1)c(CCc1ccccc1)cn2-c1ccc(OCCO)cc1 | Homo sapiens | CHEMBL3361803 | single protein format |
| CHEMBL4079052 |  |
IC50 | = | 15.0 | nM | 521.65 | CCCCCCCCc1ccc(OCC(=O)Cn2cc(C(=O)CCCOC)c3cc(C(=O)O)ccc32)cc1 | Homo sapiens | CHEMBL4000778 | assay format |
| CHEMBL381294 |  |
IC50 | = | 15.0 | nM | 446.55 | CCCCCCCCc1ccc(OCC(=O)Cn2cc(C#N)c3cc(C(=O)O)ccc32)cc1 | Homo sapiens | CHEMBL863829 | single protein format |
| CHEMBL3326970 |  |
IC50 | = | 15.0 | nM | 534.65 | CCOc1ccc(-n2cc(CCc3ccccc3)c3cc(CCC(=O)O)ccc32)cc1.NC(CO)(CO)CO | Homo sapiens | CHEMBL3361803 | single protein format |
| CHEMBL204618 |  |
IC50 | = | 16.0 | nM | 449.55 | CCCCCCCCc1ccc(OCC(=O)Cn2cc(C=O)c3cc(C(=O)O)ccc32)cc1 | Homo sapiens | CHEMBL863829 | single protein format |
| CHEMBL207977 |  |
IC50 | = | 16.0 | nM | 463.57 | CCCCCCCCc1ccc(OCC(=O)Cn2cc(C(C)=O)c3cc(C(=O)O)ccc32)cc1 | Homo sapiens | CHEMBL863829 | single protein format |
| CHEMBL484954 |  |
IC50 | = | 16.0 | nM | 423.51 | CCCCCCCCc1ccc(OCC(=O)Cn2nnc3ccc(C(=O)O)cc32)cc1 | Homo sapiens | CHEMBL982355 | assay format |
| CHEMBL208401 |  |
IC50 | = | 20.0 | nM | 465.59 | CCCCCCCCCCOc1ccc(OCC(=O)Cn2ccc3cc(C(=O)O)ccc32)cc1 | Homo sapiens | CHEMBL863829 | single protein format |
| CHEMBL3327092 |  |
IC50 | = | 20.0 | nM | 582.7 | NC(CO)(CO)CO.O=C(O)CCc1ccc2c(c1)c(CCc1ccccc1)cn2-c1ccc(Oc2ccccc2)cc1 | Homo sapiens | CHEMBL3361803 | single protein format |
| CHEMBL1801026 |  |
IC50 | = | 22.0 | nM | 549.66 | CCCCCCCCc1ccc(OCC(=O)Cn2cc(C(=O)CCCCC(=O)O)c3cc(C(=O)O)ccc32)cc1 | Homo sapiens | CHEMBL4000778 | assay format |