P46937 | YAP1_HUMAN | Transcriptional coactivator YAP1 (YAP1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00397 | WW - WW domain | 173~202 | |
| PF00397 | WW - WW domain | 232~261 | |
| PF15238 | TEADIR3 - Omega loop, TEAD interating region 3 | 84~99 |
3D structures mapped by conservation among orthologs
[ Domain: "WW domain" // WW ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5198469 |  |
IC50 | = | 1.02 | nM | 410.42 | CNS(=O)(=O)c1ccc(Nc2ccc(C(F)(F)F)cc2)c(-c2cn(C)cn2)c1 | Homo sapiens | CHEMBL5360824 | single protein format |
| CHEMBL5407790 |  |
IC50 | < | 100.0 | nM | 339.82 | CC(C)NC(=O)c1ccc2c(Oc3cccc(Cl)c3)cccc2c1 | Homo sapiens | CHEMBL5360833 | cell-based format |
| CHEMBL5394512 |  |
IC50 | < | 100.0 | nM | 409.39 | CS(=O)(=O)NC(=O)c1ccc2c(Oc3ccc(C(F)(F)F)cc3)cccc2c1 | Homo sapiens | CHEMBL5360833 | cell-based format |
| CHEMBL5432186 |  |
IC50 | < | 100.0 | nM | 370.33 | N#CCNC(=O)c1ccc2c(Oc3ccc(C(F)(F)F)cc3)cccc2c1 | Homo sapiens | CHEMBL5360833 | cell-based format |
| CHEMBL4474533 |  |
IC50 | = | 328.0 | nM | 528.65 | O=C(CC1CCN(C(=O)CCc2ccccc2)CC1)N[C@@H](Cc1ccc(OCc2ccccc2)cc1)C(=O)O | Homo sapiens | CHEMBL4419934 | single protein format |
| CHEMBL5406194 |  |
IC50 | = | 391.0 | nM | 470.4 | CC(NC(=O)c1cc2nc(N(C)C)n(-c3ccc(Br)cc3)c2s1)c1ccccn1 | Homo sapiens | CHEMBL5360824 | single protein format |
| CHEMBL5398453 |  |
IC50 | = | 454.0 | nM | 312.39 | COC(=O)c1cc(S(N)(=O)=O)ccc1NC1CCCCC1 | Homo sapiens | CHEMBL5360824 | single protein format |
| CHEMBL4541982 |  |
IC50 | = | 528.0 | nM | 567.69 | COC(=O)[C@H](Cc1ccc(OCc2ccccc2)cc1)NC(=O)CC1CCN(C(=O)CCc2ccc(C#N)cc2)CC1 | Homo sapiens | CHEMBL4419934 | single protein format |
| CHEMBL4476836 |  |
IC50 | = | 990.0 | nM | 542.68 | COC(=O)[C@H](Cc1ccc(OCc2ccccc2)cc1)NC(=O)CC1CCN(C(=O)CCc2ccccc2)CC1 | Homo sapiens | CHEMBL4419934 | single protein format |
| CHEMBL4547935 |  |
IC50 | = | 1000.0 | nM | 581.76 | O=C(CC1CCN(C(=O)CCc2ccccc2)CC1)N[C@@H](Cc1ccc(OCc2ccccc2)cc1)C(=O)NCC1CC1 | Homo sapiens | CHEMBL4419934 | single protein format |
| CHEMBL4469116 |  |
IC50 | = | 1000.0 | nM | 567.73 | O=C(CC1CCN(C(=O)CCc2ccccc2)CC1)N[C@@H](Cc1ccc(OCc2ccccc2)cc1)C(=O)NC1CC1 | Homo sapiens | CHEMBL4419934 | single protein format |
| CHEMBL4558314 |  |
IC50 | = | 1000.0 | nM | 572.7 | COC(=O)[C@H](Cc1ccc(OCc2ccccc2)cc1)NC(=O)CC1CCN(C(=O)CCc2ccccc2OC)CC1 | Homo sapiens | CHEMBL4419934 | single protein format |
| CHEMBL4546804 |  |
IC50 | = | 1000.0 | nM | 560.67 | COC(=O)[C@H](Cc1ccc(OCc2ccccc2)cc1)NC(=O)CC1CCN(C(=O)CCc2ccc(F)cc2)CC1 | Homo sapiens | CHEMBL4419934 | single protein format |
| CHEMBL4572362 |  |
IC50 | = | 1000.0 | nM | 556.7 | COC(=O)[C@H](Cc1ccc(OCc2ccccc2)cc1)NC(=O)CC1CCN(C(=O)CCc2cccc(C)c2)CC1 | Homo sapiens | CHEMBL4419934 | single protein format |
| CHEMBL4474075 |  |
IC50 | = | 1000.0 | nM | 586.73 | CCOc1ccc(CCC(=O)N2CCC(CC(=O)N[C@@H](Cc3ccc(OCc4ccccc4)cc3)C(=O)OC)CC2)cc1 | Homo sapiens | CHEMBL4419934 | single protein format |
| CHEMBL4519785 |  |
IC50 | = | 1000.0 | nM | 496.6 | CC(C)(C)OC(=O)N1CCC(CC(=O)N[C@@H](Cc2ccc(OCc3ccccc3)cc2)C(=O)O)CC1 | Homo sapiens | CHEMBL4419934 | single protein format |