P46663 | BKRB1_HUMAN | B1 bradykinin receptor (BDKRB1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00001 | 7tm_1 - 7 transmembrane receptor (rhodopsin family) | 54~312 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL522947 |  |
IC50 | = | 1.8 | nM | 487.05 | Cc1c(C(=O)NCCC2CCN(C3CCN(C)CC3)CC2)n[nH]c1NC(=O)c1ccccc1Cl | Homo sapiens | CHEMBL982614 | single protein format |
| CHEMBL256671 |  |
IC50 | = | 3.93 | nM | 483.25 | COC(=O)c1c(Cl)cc(Cl)cc1-c1cnc([C@@H](C)NC(=O)[C@@](C)(O)C(F)(F)F)c(F)c1 | Homo sapiens | CHEMBL947207 | single protein format |
| CHEMBL402831 |  |
IC50 | = | 4.47 | nM | 490.82 | Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)[C@@](C)(O)C(F)(F)F)c(F)c2)no1 | Homo sapiens | CHEMBL947207 | single protein format |
| CHEMBL258324 |  |
IC50 | = | 4.9 | nM | 490.82 | C[C@@H](NC(=O)[C@@](C)(O)C(F)(F)F)c1ncc(-c2cc(Cl)cc(F)c2-c2nnn(C)n2)cc1F | Homo sapiens | CHEMBL947207 | single protein format |
| CHEMBL257729 |  |
IC50 | = | 6.65 | nM | 507.27 | Cc1noc(-c2c(Cl)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)[C@@](C)(O)C(F)(F)F)c(F)c2)n1 | Homo sapiens | CHEMBL947207 | single protein format |
| CHEMBL258326 |  |
IC50 | = | 6.65 | nM | 490.82 | Cc1noc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)[C@@](C)(O)C(F)(F)F)c(F)c2)n1 | Homo sapiens | CHEMBL947207 | single protein format |
| CHEMBL1744084 |  |
IC50 | = | 8.0 | nM | 579.75 | CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCN(c4ccncc4)CC3)cc2)N=C(C2CCCCC2)c2ccccc21 | Homo sapiens | CHEMBL653555 | single protein format |
| CHEMBL207947 |  |
IC50 | = | 11.0 | nM | 579.73 | Cc1ccc(S(=O)(=O)N2CCCC[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNC(C)(C)C)ccc32)cc1C(F)(F)F | Homo sapiens | CHEMBL866612 | single protein format |
| CHEMBL437509 |  |
IC50 | = | 13.0 | nM | 565.7 | CC(C)CNCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1 | Homo sapiens | CHEMBL866612 | single protein format |
| CHEMBL206554 |  |
IC50 | = | 14.0 | nM | 553.79 | CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1csc2ccccc12 | Homo sapiens | CHEMBL866612 | single protein format |
| CHEMBL381979 |  |
IC50 | = | 15.0 | nM | 546.18 | Cc1ccc(S(=O)(=O)N2CCCC[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNC(C)(C)C)ccc32)cc1Cl | Homo sapiens | CHEMBL866612 | single protein format |
| CHEMBL380117 |  |
IC50 | = | 16.0 | nM | 563.69 | O=C(C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCCc2cc(CNCC3CC3)ccc21 | Homo sapiens | CHEMBL866612 | single protein format |
| CHEMBL381372 |  |
IC50 | = | 21.0 | nM | 567.67 | COCCNCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1 | Homo sapiens | CHEMBL866612 | single protein format |
| CHEMBL381366 |  |
IC50 | = | 23.0 | nM | 565.7 | CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1 | Homo sapiens | CHEMBL866612 | single protein format |
| CHEMBL1744082 |  |
IC50 | = | 24.7 | nM | 584.81 | CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCC(N4CCCCC4)CC3)cc2)N=C(C2CCCCC2)c2ccccc21 | Homo sapiens | CHEMBL653555 | single protein format |
| CHEMBL402114 |  |
IC50 | = | 43.6 | nM | 417.33 | COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)[C@@](C)(O)C(F)(F)F)c(F)c1 | Homo sapiens | CHEMBL947207 | single protein format |
| CHEMBL205981 |  |
IC50 | = | 48.0 | nM | 549.66 | O=C(C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCCc2cc(CNC3CC3)ccc21 | Homo sapiens | CHEMBL866612 | single protein format |
| CHEMBL439505 |  |
IC50 | = | 58.0 | nM | 563.69 | O=C(C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCCc2cc(CNC3CCC3)ccc21 | Homo sapiens | CHEMBL866612 | single protein format |
| CHEMBL203174 |  |
IC50 | = | 59.0 | nM | 579.73 | CC(C)(C)CNCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1 | Homo sapiens | CHEMBL866612 | single protein format |
| CHEMBL205501 |  |
IC50 | = | 62.0 | nM | 537.65 | CN(C)Cc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1 | Homo sapiens | CHEMBL866612 | single protein format |